Hydrogen sulfide sustained-release dressing and manufacturing method thereof

A manufacturing method, hydrogen sulfide technology, applied in medical science, bandages, etc., can solve the problems of cell apoptosis or inflammation, cell toxicity, hydrogen sulfide toxicity, etc., and achieve the effect of promoting healing

Active Publication Date: 2019-05-24
BENQ MATERIALS WUHU CORP +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High concentrations of hydrogen sulfide are toxic to cells and can cause adverse reactions such as apoptosis or inflammation
Although low concentrations of hydrogen sulfide are helpful for wound healing, high concentrations of hydrogen sulfide are toxic, thus limiting the medical application of hydrogen sulfide

Method used

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  • Hydrogen sulfide sustained-release dressing and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Get 15.4 grams of styrene-isoprene-styrene (SIS) copolymer (Kraton D1161, purchased from Kraton, the U.S.), 36.55 grams of C9 modified resin (Wingtack 86, purchased from CRAY VALLEY, the U.S.), 6.4 gram of mineral oil (Kaydol white mineral oil purchased from Sonneborn, the U.S.) and 1 gram of hindered phenol tetrakis (3,5-di-tert-butyl-4-hydroxyl) pentaerythritol phenylpropionate (Chinox 1010, purchased from Double Bond Chemicals , Taiwan) stirred at 180° C. under nitrogen atmosphere for 60 minutes, then cooled to 120° C., added 40 grams of sodium carboxymethylcellulose, 0.5 grams of surfactant Tween 80 and 0.15 grams of sodium hydrosulfide, stirred for 10 Minutes later, it is poured into a mold and heat-pressed at 90°C to form a hydrogen sulfide sustained-release dressing.

Embodiment 2

[0045] The steps and materials of Example 2 are the same as in Example 1, except that 36.5 g of C9 modified resin is used instead of 36.55 g of C9 modified resin and 0.2 g of sodium hydrosulfide is used instead of 0.15 g of sodium hydrosulfide.

Embodiment 3

[0047] The steps and materials of Example 3 are the same as in Example 1, except that 15.3 grams of styrene-isoprene-styrene (SIS) copolymer is used instead of 15.4 grams of styrene-isoprene-styrene (SIS) Copolymer, replacing 36.55 grams of C9 modified resin with 36.3 grams of C9 modified resin and replacing 0.15 grams of sodium hydrosulfide with 0.5 grams of sodium hydrosulfide.

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PUM

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Abstract

The invention discloses a hydrogen sulfide slow-release dressing and a manufacturing method thereof. The hydrogen sulfide sustained-release dressing comprises a hydrocolloid, a surfactant and sodium hydrosulfide. By adjusting the proportion of the hydrophilic polymer in the hydrocolloid and the surfactant, the hydrocolloid can have different water absorption rates, and further the sodium hydrosulfide coated in the hydrocolloid has different hydrogen sulfide release rates along with the water absorption rates. The hydrogen sulfide slow-release dressing can slowly release hydrogen sulfide without generating cytotoxicity, so that healing of chronic wounds can be effectively promoted.

Description

technical field [0001] The invention relates to a hydrogen sulfide slow-release dressing and a manufacturing method thereof, in particular to a hydrogen sulfide slow-release dressing capable of slowly releasing hydrogen sulfide gas to promote chronic wound healing and a manufacturing method thereof. Background technique [0002] Hydrogen sulfide (H 2 S) is the third discovered endogenous gas phase transport substance after nitric oxide and carbon monoxide. In animal experiments, it has been proved that hydrogen sulfide gas has the effects of relaxing blood vessels, inhibiting the proliferation of vascular smooth muscle cells, inducing the apoptosis of vascular smooth muscle cells, promoting the proliferation of microvascular endothelial cells, anti-inflammatory response and antioxidant effects. It is known in the prior art that cells produce hydrogen sulfide gas at a slow rate and at low concentrations, but an external hydrogen sulfide donor (donor) cannot truly simulate th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
Inventor 叶丽仙赵志源王毓璞
Owner BENQ MATERIALS WUHU CORP
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