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Hollow manganese dioxide nanoparticles and preparation method thereof

A nanoparticle, manganese dioxide technology, applied in the direction of manganese oxide/manganese hydroxide and the like, can solve the problems of harsh alkali etching conditions, poor controllability of morphology and size, complex preparation method, etc., and achieves low cost and simple method. , the effect of simple operation

Active Publication Date: 2019-05-24
DONGHUA UNIV
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  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a hollow manganese dioxide nanoparticle and its preparation method, which overcomes the complex preparation method, long cycle, poor shape and size controllability, high cost and harsh alkali etching conditions of the prior art. Defects, the method is simple in design, low in price, energy-saving and environmentally friendly, and can prepare hollow manganese dioxide nanoparticles with controllable morphology and stable structure, which is in line with the concept of green energy saving

Method used

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  • Hollow manganese dioxide nanoparticles and preparation method thereof
  • Hollow manganese dioxide nanoparticles and preparation method thereof
  • Hollow manganese dioxide nanoparticles and preparation method thereof

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Embodiment 1

[0031] (1) Dissolve 20mg of PLGA in 2mL of acetone, add dropwise to 10mL of deionized water under magnetic stirring (800rpm), continue stirring for 3h, and then dry in a vacuum oven for 12h.

[0032] (2) Another 10 mg of potassium permanganate was dissolved in 10 mL of deionized water, then added to the PLGA nanoparticles prepared in step (1), and reacted for 18 h under magnetic stirring (600 rpm). Centrifuge to obtain a brown precipitate, wash three times with deionized water, and centrifuge to obtain PLGA-MnO 2 nanoparticles.

[0033] (3) The PLGA-MnO prepared in step 2 2 Nanoparticles were dispersed in acetone, sonicated for 15 min, washed three times with deionized water, and centrifuged to obtain MnO 2 nanoparticles.

[0034] TEM image of PLGA NPs prepared in this patent, such as figure 1 As shown in a, it can be seen that the PLGA NPs are regular spherical, uniformly dispersed, and the particle size is 100-120nm. Prepared PLGA-MnO 2 TEM images of nanoparticles, su...

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Abstract

The invention relates to hollow manganese dioxide nanoparticles and a preparation method thereof. The nanoparticles are prepared by taking PLGA nanoparticles (PLGA NPs) as a template, reducing potassium permanganate (KMnO4) by surface hydroxyl (-OH), growing a layer of manganese dioxide on the surface of the potassium permanganate, and then etching away PLGA by acetone. The prepared hollow manganese dioxide nanoparticles are controllable in particle size, adjustable in wall thickness, large in pore volume, simple in preparation method, low in raw material price and capable of serving as a carrier of a catalyst or an adsorbent, and conforms to the concept of green energy conservation; and as a drug nano-carrier, especially as a tumor microenvironment responsive drug nano-carrier, the hollowmanganese dioxide nanoparticles have the characteristics that drug is controlled to be released, a tumor treatment effect is improved, magnetic resonance imaging is achieved, and the practical valueis high.

Description

technical field [0001] The invention belongs to the field of nano carrier and its preparation, in particular to a hollow manganese dioxide nano particle and its preparation method. Background technique [0002] MnO 2 It has good biocompatibility and responsiveness to the tumor microenvironment. It reacts with the metabolite glutathione (GSH) of cancer cells under weakly acidic conditions, and decomposes the produced Mn 2+ Can be used as a magnetic resonance contrast agent. At the same time, MnO 2 It can also be used as a catalyst to catalyze the decomposition of tumor endogenous hydrogen peroxide (H 2 o 2 ) to release oxygen (O 2 ), to solve the problem of tumor hypoxia. MnO 2 As an anti-tumor nano-agent, it has been widely used in the integration of tumor diagnosis and treatment. [0003] Traditional MnO 2 The preparation methods of NPs include hydrothermal method, biomineralization method, silica template method and so on. For example: Chen et al prepared solid M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G45/02
Inventor 朱利民王海军谢晓田
Owner DONGHUA UNIV
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