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A kind of hollow manganese dioxide nanoparticles and preparation method thereof

A nanoparticle and manganese dioxide technology, applied in the direction of manganese oxide/manganese hydroxide, etc., can solve the problems of harsh alkali etching conditions, poor controllability of shape and size, complicated preparation methods, etc., and achieve low cost and simple method , the effect of simple operation

Active Publication Date: 2021-06-11
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a hollow manganese dioxide nanoparticle and its preparation method, which overcomes the complex preparation method, long cycle, poor shape and size controllability, high cost and harsh alkali etching conditions of the prior art. Defects, the method is simple in design, low in price, energy-saving and environmentally friendly, and can prepare hollow manganese dioxide nanoparticles with controllable morphology and stable structure, which is in line with the concept of green energy saving

Method used

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  • A kind of hollow manganese dioxide nanoparticles and preparation method thereof
  • A kind of hollow manganese dioxide nanoparticles and preparation method thereof
  • A kind of hollow manganese dioxide nanoparticles and preparation method thereof

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Embodiment 1

[0031] (1) Dissolve 20mg of PLGA into 2mL of acetone, add dropwise to 10mL of deionized water under magnetic stirring (800rpm), continue stirring for 3h, and then put it into a vacuum drying oven to dry for 12h.

[0032] (2) Another 10 mg of potassium permanganate was dissolved in 10 mL of deionized water, then added to the PLGA nanoparticles prepared in step (1), and reacted for 18 h under magnetic stirring (600 rpm). Centrifuge to obtain a brown precipitate, wash three times with deionized water, and centrifuge to obtain PLGA-MnO 2 nanoparticles.

[0033] (3) The PLGA-MnO prepared in step 2 2 Nanoparticles were dispersed in acetone, sonicated for 15 min, washed three times with deionized water, and centrifuged to obtain MnO 2 nanoparticles.

[0034] TEM image of PLGA NPs prepared in this patent, such as figure 1 As shown in a, it can be seen that the PLGA NPs are regular spherical, uniformly dispersed, and the particle size is 100-120nm. Prepared PLGA-MnO 2 TEM images...

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Abstract

The invention relates to a hollow manganese dioxide nanoparticle and a preparation method thereof. The nanoparticle uses PLGA nanoparticles (PLGA NPs) as a template to reduce potassium permanganate (KMnO 4 ), grown a layer of manganese dioxide on its surface, and then etched away PLGA with acetone. The prepared hollow manganese dioxide nanoparticles have controllable particle size, adjustable wall thickness, large pore volume, simple preparation method, low raw material price, conform to the concept of green energy saving, and can be used as a carrier of catalyst or adsorbent; and As a drug nanocarrier, especially a tumor microenvironment-responsive drug nanocarrier, it can realize controlled release of drugs, improve the effect of tumor treatment, and has good practical value with magnetic resonance imaging.

Description

technical field [0001] The invention belongs to the field of nano carrier and its preparation, in particular to a hollow manganese dioxide nano particle and its preparation method. Background technique [0002] MnO 2 It has good biocompatibility and responsiveness to the tumor microenvironment. It reacts with the metabolite glutathione (GSH) of cancer cells under weakly acidic conditions, and decomposes the produced Mn 2+ Can be used as a magnetic resonance contrast agent. At the same time, MnO 2 It can also be used as a catalyst to catalyze the decomposition of tumor endogenous hydrogen peroxide (H 2 o 2 ) to release oxygen (O 2 ), to solve the problem of tumor hypoxia. MnO 2 As an anti-tumor nano-agent, it has been widely used in the integration of tumor diagnosis and treatment. [0003] Traditional MnO 2 The preparation methods of NPs include hydrothermal method, biomineralization method, silica template method and so on. For example: Chen et al prepared solid M...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G45/02
Inventor 朱利民王海军谢晓田
Owner DONGHUA UNIV
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