Production method of sodium bicarbonate injection

A technology of sodium bicarbonate and its production method, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, and devices that make medicines into special physical or ingestible forms, and can solve the problems of inability to remove impurities and bacteria, use restrictions, Can not remove impurities and microorganisms to achieve the effect of avoiding insufficient dosage, avoiding waste, and improving purity

Inactive Publication Date: 2019-05-28
SHANGHAI WORLDBEST ANHUI JINHUI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technical solution cannot efficiently remove impurities and microorganisms in the production process. At the same time, it cannot set and replace the filter element in the filter equipment to efficiently filter the solution. Cleaning of impurities and bacteria in the solution; the use of this technical solution is limited

Method used

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  • Production method of sodium bicarbonate injection
  • Production method of sodium bicarbonate injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] a. Add water for injection into the dilute preparation tank, and cool the water for injection in the dilute preparation tank to 15°C;

[0029] b. Add the soaked activated carbon for needles and sodium bicarbonate into the dilute preparation tank in step a, and feed pure carbon dioxide gas into the dilute distribution tank until the potting is completed;

[0030] c. Add water for injection at 15°C to the dilute mixing tank in step b, and start the dilute mixing tank for stirring;

[0031] d. Pass the solution in the dilute distribution tank into the titanium rod filter for filtration, and the filtration pressure of the titanium rod filter is 0.4MPa;

[0032] e. Pass the solution in the titanium rod filter into a 0.22 μm / 0.45 μm filter for 10 minutes;

[0033] f. Transfer the solution in the 0.22 μm / 0.45 μm filter to the dilution tank of step d for further stirring, repeat step f, step d, and step e three times;

[0034] g. Transport the solution treated in step f to a ...

Embodiment 2

[0038] a. Add water for injection into the dilute preparation tank, and cool the water for injection in the dilute preparation tank to 25°C;

[0039] b. Add the soaked activated carbon for needles and sodium bicarbonate into the dilute preparation tank in step a, and feed pure carbon dioxide gas into the dilute distribution tank until the potting is completed;

[0040] c. Add water for injection at 25°C to the dilute mixing tank in step b, and start the dilute mixing tank for stirring;

[0041] d. Pass the solution in the dilute tank to the titanium rod filter for filtration, and the filtration pressure of the titanium rod filter is 0.1MPa;

[0042] e. Pass the solution in the titanium rod filter into a 0.22 μm / 0.45 μm filter for 10 minutes;

[0043] f. Transfer the solution in the 0.22 μm / 0.45 μm filter to the dilution tank of step d for further stirring, and repeat step f, step d, and step e four times;

[0044]g. Transport the solution treated in step f to a 0.22 μm termi...

Embodiment 3

[0048] a. Add water for injection into the dilute preparation tank, and cool the water for injection in the dilute preparation tank to 30°C;

[0049] b. Add the soaked activated carbon for needles and sodium bicarbonate into the dilute preparation tank in step a, and feed pure carbon dioxide gas into the dilute preparation tank until the potting is completed;

[0050] c. Add 30°C water for injection into the dilute mixing tank in step b, and start the dilute mixing tank for stirring;

[0051] d. Pass the solution in the dilute tank into the titanium rod filter for filtration, and the filtration pressure of the titanium rod filter is 0.25MPa;

[0052] e. Pass the solution in the titanium rod filter into a 0.22 μm / 0.45 μm filter for 10 minutes;

[0053] f. Transfer the solution in the 0.22 μm / 0.45 μm filter to the dilution tank of step d for further stirring, repeat step f, step d, and step e five times;

[0054] g. Transport the solution treated in step f to a 0.22 μm termina...

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Abstract

The invention belongs to the technical field of medicine preparation and in particular relates to a production method of sodium bicarbonate injection. According to the production method, step a to step i are mutually matched to prepare the sodium bicarbonate injection; step a to step g are mutually matched to filter impurities in the injection and bacteria in a solution are filtered and cleaned; 4000L of injection water is added into a diluted preparation pot in step a; after injection water with the temperature of lower than 30 DEG C is added into the diluted preparation pot in step c, the amount of the injection water in the diluted preparation pot reaches 5000L. Step a and step b are matched to primarily dissolve sodium bicarbonate; 250kg of the sodium bicarbonate is added in step b; step a and step c are matched to ensure that the total amount of a solution is 5000L; 5000L of water is directly added in step a; when 250kg of the sodium bicarbonate is added in step b, the total volume of the solution is greater than 5000L, and the concentration of the sodium bicarbonate is influenced. The production method is mainly used for producing the sodium bicarbonate injection and impurities in the solution can be sufficiently filtered.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a production method of sodium bicarbonate injection. Background technique [0002] Sodium bicarbonate injection is an electrolyte liquid that clinically regulates the acid-base balance in the body, and is the drug of choice for correcting acidosis. As one of the important clinical medicines for regulating acid-base balance among the 307 kinds of national essential medicines, it is a common emergency medicine in clinical practice. The existing sodium bicarbonate injection usually uses edetate disodium and edetate calcium sodium as complexing agents for Ca2+, Mg2+ and other metal ions in the complexing liquid. However, due to the presence of a small amount of CO32- ions in the sodium bicarbonate injection, adding calcium sodium edetate is easy to form calcium carbonate, so that the visible foreign matter does not meet the requirements. However, if the amount of EDTA ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K33/00A61P3/12A61J3/00
Inventor 张小磊侯友刘将王大斌张杰朱猛杨东
Owner SHANGHAI WORLDBEST ANHUI JINHUI PHARMA CO LTD
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