Application of SGLT2 inhibitor in combination with ARB to preparation of medicament for treating hypertensive disease and other diseases
A technology of inhibitors and uses, applied in the field of application of SGLT2 inhibitors and ARBs in the preparation of drugs for the treatment of hypertension and other diseases, can solve problems such as failure to receive effective treatment, achieve improved therapeutic effects, and enhance the antihypertensive effect , good therapeutic effect
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[0029] Embodiment 1: Compound (1) and irbesartan co-administration and the pharmacodynamic effect of each individual administration on streptozotocin (STZ)-induced spontaneously hypertensive rat (SHR) diabetic nephropathy and lowering blood pressure Research.
[0030] 1. Test drug
[0031] Drug name: the complex of compound (1) and L-proline, prepared according to the method disclosed in WO2016050134; irbesartan, provided by Jiangsu Hengrui Medicine Co., Ltd.
[0032] Preparation method: the complex of compound (1) and L-proline is prepared with 0.5% CMC-Na / 1% Tween 80 (w / v) deionized water; irbesartan is prepared with 0.5% CMC-Na / 1 % Tween 80 (w / v) deionized water preparation.
[0033] 2. Experimental animals
[0034] Wistar Kyoto rats: male, purchased at 8-9 weeks old, with a purchased weight of 175-205g;
[0035] SHR: male, purchased at 8-9 weeks old, with a purchased body weight of 175-205 g.
[0036] All were purchased from Beijing Weitong Lihua Experimental Animal T...
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