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Traditional Chinese medicine composition, preparation method and application in preparing drug for treating chronic non-atrophic gastritis

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, preparation and treatment of chronic non-atrophic gastritis, can solve the problems of untimely treatment, affecting the quality of life of patients, long course of disease, etc., and achieve inhibition of gram-positive bacteria, hemostasis Fast and sure effect

Active Publication Date: 2019-05-31
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the clinical symptoms of the disease are not very serious, most patients do not pay much attention to it, and if it is not treated in time, the disease will have a long course and persist for a long time, which will greatly affect the quality of life of the patients.

Method used

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  • Traditional Chinese medicine composition, preparation method and application in preparing drug for treating chronic non-atrophic gastritis

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Effect test

Embodiment 1

[0023] The content of the present invention includes the following components in parts by weight: 3 parts of Hericium erinaceus mycelium, 3 parts of Coptidis rhizome, 1 part of Evodia rutaecarpa, 3 parts of vinegar corydalis and 1 part of Baiji.

[0024] Take Hericium erinaceus, add volume concentration and be 60% ethanol to extract three times, add 6 times of 60% ethanol for the first time, soak for 0.5 hour, extract for 2 hours, add 4 times of 60% ethanol for the second time, extract for 1.5 hours , add 4 times the amount of 60% ethanol for the third time, extract for 1.5 hours, filter, combine the extracts, reclaim the ethanol, concentrate under reduced pressure to a relative density of 1.10~1.15 (60°C), to obtain Hericium erinaceus mycelium fluid extract, spare. For the rest of Coptis chinensis, Evodia rutaecarpa, Vinegar Corydalis Corydalis, Bai and four medicinal materials, add acid water (glacial acetic acid to adjust the pH to 3.0) and decoct three times. Add 6 times t...

Embodiment 2

[0029] Take Hericium erinaceus, add volume concentration and be 50% ethanol to extract three times, add 6 times of 50% ethanol for the first time, soak for 0.5 hour, extract for 2 hours, add 4 times of 50% ethanol for the second time, extract for 1.5 hours , add 4 times the amount of 50% ethanol for the third time, extract for 1.5 hours, filter, combine the extracts, reclaim the ethanol, concentrate under reduced pressure to a relative density of 1.10~1.15 (60°C), and obtain Hericium erinaceus mycelium fluid extract, spare. For the rest of Coptis chinensis, Evodia rutaecarpa, Vinegar Corydalis Corydalis, Bai and four medicinal materials, add acid water (glacial acetic acid to adjust the pH to 4.0) and decoct three times. For the first time, add 7 times the amount of acid water to soak for 0.5 hours, decoct for 2 hours, and then decoct for 2 hours. Add 5 times the amount of acid water three times, decoct for 1.5 hours respectively, combine the extracts, concentrate under reduce...

Embodiment 3

[0031] Analysis and Evaluation of Effectiveness Research Results

[0032] Control group: patent application number 201310013628.0 (a medicinal composition for stomach diseases against Helicobacter pylori).

[0033] (1) Anti-Helicobacter pylori (Hp) test of this application: It is divided into two parts: in vitro antibacterial test and in vivo effect test on Hp infection-induced chronic non-atrophic gastritis model in rats:

[0034] ① In vitro antibacterial test: routinely prepare Hp bacterial liquid (standard strain ATCC43504), culture and count viable bacteria after culturing at 37°C for 7 days, and adjust the bacterial concentration to 1×10 8 CFU / mL was prepared as the parent bacterial suspension and stored at 4°C for future use. During the test, the mother bacteria solution was taken to adjust the bacterial concentration to 2×10 7 CFU / mL is used as the working bacterial suspension. Accurately weigh an appropriate amount of the dry extract of this application, dissolve it...

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Abstract

The invention belongs to a traditional Chinese medicine composition, a preparation method and application in preparing a drug for treating chronic non-atrophic gastritis. The traditional Chinese medicine composition is prepared from, by weight, 3 parts of hericium erinaceus mycelia, 3 parts of coptidis rhizoma, 1 part of fructus evodiae preparata, 3 parts of rhizoma corydalis processed with vinegar and 1 part of rhizoma bletillae. In the traditional Chinese medicine composition, the content of the rhizoma bletillae is reduced, the hericium erinaceus mycelia, the coptidis rhizoma and the rhizoma corydalis processed with vinegar are used as main ingredients, the fructus evodiae preparata and the rhizoma bletillae are used as accessory ingredients, the specific ratio of the raw materials is limited, and the extracting methods of the coptidis rhizoma, the fructus evodiae preparata, the rhizoma corydalis processed with vinegar and the rhizoma bletillae are limited. It is found that the traditional Chinese medicine composition has a good effect on treatment of the chronic non-atrophic gastritis. Compared with an original formula, the effect is not reduced but is improved, it is possiblethat the proportion of the five specific components plays a role of compatibility of traditional Chinese medicine and the content of effective components is increased due to the glacial acetic acid extracting method, and a very good effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition, a preparation method and its application in preparing and treating chronic non-atrophic gastritis. Background technique [0002] Chronic non-atrophic gastritis (CNAG) refers to chronic gastritis that is not accompanied by atrophic changes of the gastric mucosa and infiltrated by chronic inflammatory cells mainly composed of lymphocytes and plasma cells in the gastric mucosa. According to the distribution of lesions, it can be further divided into antral gastritis, gastritis, and pangastritis, which are a kind of chronic gastritis. As a common clinical disease of the digestive system, its clinical manifestations lack specificity, and most patients have symptoms of upper gastrointestinal dyspepsia, such as fullness after meals, dull pain in the upper abdomen, burning sensation in the epigastric cavity, bel...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P1/04
Inventor 何述金周代俊周准何承东
Owner HUNAN XINHUI PHARMA
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