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A kind of preparation method of implant body with porosity gradient change

A gradient change, implant technology, applied in the field of biological bone implantation and repair, can solve problems such as inability to match mechanical performance requirements, stress shielding, etc., and achieve the effect of facilitating transmission and proliferation, increasing stiffness, and high simulation.

Active Publication Date: 2020-12-29
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above defects or improvement needs of the prior art, the present invention provides a method for preparing an implant with a gradient porosity change, in which the structural design of the key structure continuous gradient minimal curved surface porous structure overcomes the traditional uniform porous structure Dense implants are likely to cause stress shielding and cannot match the different mechanical performance requirements of different parts. The new gradient porous material for bio-skeletal repair obtained by manufacturing is more applicable

Method used

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  • A kind of preparation method of implant body with porosity gradient change
  • A kind of preparation method of implant body with porosity gradient change
  • A kind of preparation method of implant body with porosity gradient change

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preparation example Construction

[0025] A method for preparing an implant with a gradient porosity change. According to the requirements of the implant site, a gradient porous structure is customized; a three-dimensional model of a continuous gradient porous structure based on a minimal curved surface is constructed through mathematical modeling, and then the model is Output in STL format; import the STL file into the additive manufacturing forming equipment, and finally obtain a gradient porous structure consistent with the design model through layer-by-layer accumulation; finally, a gradient porous implant with good performance can be obtained after proper post-processing. For biological tissue repair.

[0026] in particular, figure 1 It is a flow chart of the preparation method of the implant with the gradient change of porosity constructed according to the preferred embodiment of the present invention, such as figure 1 As shown, the method includes the following steps:

[0027] (1) According to differen...

Embodiment 1

[0042] (1) According to the damaged part of the patient is cortical bone, the porosity of the porous structure is required to be 10%-20%, and the Young's modulus is about 30-20GPa, so it matches the Swartz Primitive structure and Ti-24Nb-4Zr-8Sn material, the porosity Grading from 15% to 20%, the Young's modulus is predicted to be 35.0-22.9 GPa.

[0043] (2) First confirm that the porosity change equation along the X direction is:

[0044] f(x=0)=0.15;

[0045]

[0046] Among them, x is the space coordinate, L is the total length of the porous structure in the X direction, and the Swartz Primitive implicit function equation is combined to generate the Swartz Primitive minimal surface gradient porous structure.

[0047] Use the algorithm to distinguish the inside and outside of the surface, and close the inner boundary of the surface to form a rod-shaped solid model with a minimal curved surface; or give the surface a thickness to form a thin-walled solid model with a minim...

Embodiment 2

[0052] (1) According to the damaged part of the patient is cancellous bone, the porosity of the porous structure is required to be 50%-90%, and the Young's modulus is about 5.0-3.0GPa, so it matches the Schoen Gyroid structure and Ti-6Al-4V material, the porosity Grading from 70% to 75%, the Young's modulus is predicted to be 5.5-3.3 GPa.

[0053] (2) First confirm that the equation of porosity changing with space is:

[0054] f(x=0)=0.70;

[0055]

[0056] Among them, x is the space coordinate, L is the total length of the porous structure in the X direction, and the Gyroid implicit function equation is combined to generate the Gyroid minimal surface gradient porous structure.

[0057] Use the algorithm to distinguish the inside and outside of the surface, and close the inner boundary of the surface to form a rod-shaped solid model with a minimal curved surface; or give the surface a thickness to form a thin-walled solid model with a minimal curved surface;

[0058] (3) ...

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Abstract

The invention belongs to the bio-skeleton implantation and restoration field, and discloses a method for preparing an implant with change of porosity gradient. The method includes the following steps:(a) determining the required contour, gradient porosity and Young's modulus for the implant to be formed, and establishing a continuous gradient minimally curved porous structure to satisfy the requirement for the implant to be formed (b) adjusting the continuous gradient minimally curved porous structure to be the same as a three-dimensional structure required for the implant to be formed, and obtaining a three-dimensional model of the continuous gradient minimally curved porous structure; and (c) selecting the material of the implant to be formed, performing forming on the three-dimensionalmodel by means of an additive material manufacturing process to obtain the desired implant to be formed. The method for preparing an implant with change of porosity gradient overcomes the problem that the traditional uniform porous structure dense implant is easy to cause stress shielding and cannot match different mechanical performance requirements of different parts, and the newly obtained bio-skeleton restoration new gradient porous material is more applicable.

Description

technical field [0001] The invention belongs to the field of biological bone implantation and repair, and more particularly relates to a preparation method of an implant with a gradient change in porosity. Background technique [0002] Tissue engineering technology is a popular technology in the field of regenerative medicine. With the help of growth factors, medical scientists cultivate human cells on tissue engineering scaffolds, grow into tissues and even organs with specific functions through cell proliferation and differentiation, and realize the restoration of human body defects. graft repair. Among them, tissue engineering scaffolds play a vital role in the process of cell proliferation and differentiation. As a support structure for cell growth, the scaffold should be a porous structure with a smooth surface and no twists or sharp edges to facilitate the attachment and growth of cells on the scaffold. In addition, porous scaffolds also undertake the important funct...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B5/00G06T17/00
Inventor 闫春泽杨磊陈鹏史玉升李昭青伍宏志刘主峰
Owner HUAZHONG UNIV OF SCI & TECH
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