Unlock instant, AI-driven research and patent intelligence for your innovation.

Sublingual pharmaceutical composition of edaravone and (+)-2-borneol

A composition and medicine technology, applied in the field of medicine, can solve the problems such as difficult to prepare, unable to prepare qualified sublingual tablets, sublingual tablet performance (unsatisfactory stable release rate and the like)

Active Publication Date: 2020-02-07
YANTAI YENEPHARMA BIOMEDICAL +2
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, a sublingual pharmaceutical composition comprising edaravone and (+)-2-camphorol is not easy to prepare
The inventors have found that common excipients cannot produce qualified sublingual tablets, or the properties (stability, release rate, etc.) of the produced sublingual tablets are not satisfactory

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sublingual pharmaceutical composition of edaravone and (+)-2-borneol
  • Sublingual pharmaceutical composition of edaravone and (+)-2-borneol
  • Sublingual pharmaceutical composition of edaravone and (+)-2-borneol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Material name Dosage (g) Edaravone 30 (+)-2-Bornyl alcohol 1.5 lactose 39.7 Hypromellose 4 Croscarmellose 4 Magnesium stearate sodium 0.8

[0034] Preparation method: Mix (+)-2-camphor, edaravone, lactose, hypromellose, croscarmellose sodium and magnesium stearate evenly, and press into tablets.

Embodiment 2

[0036] Material name Dosage (g) Edaravone 30 (+)-2-Bornyl alcohol 2 lactose 39.2 Hypromellose 4 Croscarmellose 4 Magnesium stearate sodium 0.8

[0037] Preparation method: Mix (+)-2-camphor, edaravone, lactose, hypromellose, croscarmellose sodium and magnesium stearate evenly, and press into tablets.

Embodiment 3

[0039] Material name Dosage (g) Edaravone 1.5 (+)-2-Bornyl alcohol 30 lactose 39.7 Hypromellose 4 Croscarmellose 4 Magnesium stearate sodium 0.8

[0040] Preparation method: Mix (+)-2-camphor, edaravone, lactose, hypromellose, croscarmellose sodium and magnesium stearate evenly, and press into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a sublingual preparation of edaravone and (+)-2-camphor and a preparation method thereof, wherein the sublingual preparation comprises edaravone and (+)-2-camphor , excipients, fillers, binders, disintegrants, lubricants, etc. The sublingual administration preparation can avoid the first-pass effect of the liver, and has the advantages of good sample stability, easy transportation, and convenient use.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a sublingual pharmaceutical composition of edaravone and (+)-2-camphorol and a preparation method thereof. Background technique [0002] Edaravone (chemical name: 3-methyl-1-phenyl-2-pyrazolin-5-one) is a neuroprotective agent on the market (Yakugaku Zasshi.2004,124(3):99-111) . Studies have shown that Edaravone has antioxidant activity, can significantly improve the neurological deficit symptoms of cerebral ischemia-reperfusion animals, reduce the infarct size, reduce the degree of brain damage, reduce cerebral edema, and inhibit lipid peroxidation in damaged brain tissue . [0003] [0004] Edaravone [0005] (molecular formula C 10 h 10 N 2 O, molecular weight 174.20) [0006] (+)-2-Bornhenol is the main component of natural borneol, a commonly used traditional Chinese medicine. Therapeutic effect of medicine; "Materia Medica Yanyi" pointed out that borneol "is weak ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/40A61K47/32A61K47/26A61K31/4152A61K31/045A61P9/10
CPCA61K9/0056A61K9/2018A61K31/045A61K31/4152A61K2300/00A61K9/006A61K9/2027A61P9/10A61K9/205A61K9/20A61K31/45A61K47/12A61K47/26A61K47/34A61K47/40A61K47/32
Inventor 王毅军
Owner YANTAI YENEPHARMA BIOMEDICAL