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SPR-based drug screening device

A technology for screening devices and drugs, applied to measuring devices, material analysis through optical means, instruments, etc., can solve the problems of troublesome operation, low efficiency of drug screening, and low detection efficiency of surface plasmon resonance analyzers, etc., to achieve convenient and simultaneous replacement , the effect of improving efficiency

Active Publication Date: 2019-06-21
上海陶术生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The detection efficiency of the existing surface plasmon resonance analyzer is not high, because in the drug screening process, it is necessary to manually replace the sensor chips containing different targeting molecules, which is troublesome to operate, resulting in low drug screening efficiency

Method used

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  • SPR-based drug screening device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] See Figure 1-5 In the embodiment of the present invention, an SPR-based drug screening device includes a housing 1, a liquid inlet system, an optical detection system, and an automatic switching system; the housing 1 is provided with an optical detection system, and the optical detection system includes optical The detection module 8 is electrically connected to the host computer 9, and the optical detection module 8 and the host computer 9 are electrically connected. The optical detection module 8 transmits the detection signal to the host computer 9 for curve fitting. The optical detection module 8 and the host computer 9 are both current There is technology. The optical detection module includes a laser transmitter and a laser receiver. The laser transmitter and the laser receiver are all existing technologies, which will not be repeated in this application.

[0026] The optical detection module 8 is fixedly connected with a fixed shaft 7, and the automatic switching s...

Embodiment 2

[0032] The difference between this embodiment and the first embodiment is that: the right side of the rotating drum frame 2 is connected with a sheave 24 through a connecting rod 25, and the sheave 24 is sleeved on the fixed shaft 7 and is rotatably connected with the fixed shaft 7; The wheel 24 is clamped with a notched disc 26. The grooved wheel 24 and the notched disc 26 form an intermittently rotating sheave mechanism. The notched disc 26 is fixedly connected with a rotating shaft 27, which is rotatably connected with the inner wall of the housing 1; The rotating shaft 27 is connected to a transmission shaft 29 through a first transmission gear set 28, and the transmission shaft 29 is connected to a bidirectional screw 22 for transmission through a second transmission gear set 30; the first transmission gear set 28 includes diagonally symmetrical A set of half bevel gears, the half bevel gears are sleeved and fixed with the rotating shaft 27, the upper end of the half bevel ...

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Abstract

The invention discloses an SPR-based drug screening device. The device includes a shell body, a liquid inlet system, an optical detection system, and an automatic switching system; the optical detection system is disposed in the shell body, and the optical detection system includes an optical detection module and a host computer; the automatic switching system includes a rotating drum frame sleeving outside an optical detection module, and the rotating drum frame is rotatably connected with a fixation shaft; a circumferentially distributed nesting mounting groove is distributed on the rotatingdrum frame, a circulation pool is embedded in the nesting mounting groove, and a sensor chip is disposed in the circulation pool. Through arrangement of the rotating drum frame used for fixing the circumferentially distributed circulation pool, and a grooved wheel mechanism, replacement of the circulation pool is achieved, thereby achieving the replacement of targeting molecules, and the efficiency of drug screening is improved; and arrangement of a left communication clamping connector, a right communication clamping connector, sliding blocks and a bidirectional screw rod is convenient to connect and disconnect the circulation pool and the communication clamping connectors, and is convenient for synchronous replacement of circulation pool.

Description

Technical field [0001] The invention relates to the field of drug screening equipment, in particular to a drug screening device based on SPR. Background technique [0002] Surface Plasmon Resonance (SPR) is an optical phenomenon that can be used to track the interactions between biomolecules in the natural state in real time. This method does not cause any damage to biomolecules and does not require any markers. [0003] First, a biomolecule (target molecule) is bonded to the surface of the biosensor, and then a solution containing another biomolecule (analyte) that can interact with the target molecule is injected and flows through the surface of the biosensor. The combination of biomolecules causes an increase in the surface quality of the biosensor, resulting in an increase in the refractive index in the same proportion, and changes in the reaction between biomolecules are observed. This reaction is measured in reaction units (RU): 1RU=1pg protein / mm2=1×10-6RIU (refractive ind...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/01G01N21/41
Inventor 王艾段震
Owner 上海陶术生物科技有限公司