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A drug screening device based on spr

A technology for screening devices and drugs, applied in measuring devices, phase-influence characteristic measurements, instruments, etc., can solve problems such as troublesome operation, low drug screening efficiency, and low detection efficiency of surface plasmon resonance analyzers, so as to improve efficiency and facilitate synchronization The effect of replacement

Active Publication Date: 2021-08-10
上海陶术生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The detection efficiency of the existing surface plasmon resonance analyzer is not high, because in the drug screening process, it is necessary to manually replace the sensor chips containing different targeting molecules, which is troublesome to operate, resulting in low drug screening efficiency

Method used

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  • A drug screening device based on spr
  • A drug screening device based on spr
  • A drug screening device based on spr

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] see Figure 1-5 , in an embodiment of the present invention, an SPR-based drug screening device includes a housing 1, a liquid inlet system, an optical detection system and an automatic switching system; the housing 1 is provided with an optical detection system, and the optical detection system includes an optical The detection module 8 and the upper computer 9, the optical detection module 8 and the upper computer 9 are electrically connected, the optical detection module 8 transmits the detection signal to the upper computer 9, and the curve fitting is carried out. The optical detection module 8 and the upper computer 9 are all current There is technology, and the optical detection module includes a laser transmitter and a laser receiver. Both the laser transmitter and the laser receiver are existing technologies, and this application will not repeat them.

[0026] The optical detection module 8 is fixedly connected with a fixed shaft 7, and the automatic switching s...

Embodiment 2

[0032]The difference between this embodiment and Embodiment 1 is that: the right side of the drum frame 2 is connected with a sheave 24 through a connecting rod 25, and the sheave 24 is sleeved on the fixed shaft 7 and connected in rotation with the fixed shaft 7; The wheel 24 is clamped with a notch disc 26, and the sheave 24 and the notch disc 26 form an intermittently rotating sheave mechanism. The notch disc 26 is fixedly connected with a rotating shaft 27, and the rotating shaft 27 is rotationally connected with the inner wall of the housing 1; The rotating shaft 27 is connected with the transmission shaft 29 through the first transmission gear set 28, and the transmission shaft 29 is connected and transmitted with the two-way screw mandrel 22 through the second transmission gear set 30; the first transmission gear set 28 includes diagonally symmetrical A set of half-width bevel gears, the half-width bevel gears are socketed and fixed with the rotating shaft 27, the upper ...

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Abstract

The invention discloses a drug screening device based on SPR, which includes a casing, a liquid inlet system, an optical detection system and an automatic switching system; the casing is provided with an optical detection system, and the optical detection system includes an optical detection module and a host computer; The automatic switching system includes a drum frame sleeved on the outside of the optical detection module, and the drum frame is rotatably connected with a fixed shaft; the drum frame is distributed with nested installation grooves distributed in a circle, and the nested installation grooves are nested There is a flow cell in which a sensor chip is arranged. The present invention realizes the replacement of the flow cell by providing a drum frame for fixing the flow cells distributed in a circle and a groove wheel mechanism, and then realizes the replacement of the target molecule, and improves the efficiency of drug screening; by providing the left connecting card connector, The right connection card joint, sliding block and two-way screw rod are convenient for connecting and disconnecting the flow cell and the connection card joint, and are convenient for synchronous replacement of the flow cell.

Description

technical field [0001] The invention relates to the field of drug screening equipment, in particular to an SPR-based drug screening device. Background technique [0002] Surface plasmon resonance (SPR) is an optical phenomenon that can be used to track interactions between biomolecules in their native state in real time. This method does not cause any damage to biomolecules and does not require any markers. [0003] First, a biomolecule (target molecule) is bonded to the surface of the biosensor, and then a solution containing another biomolecule (analyte) that can interact with the target molecule is injected and flows through the biosensor surface. The combination of biomolecules causes an increase in the surface mass of the biosensor, resulting in an increase in the refractive index in the same proportion, and the change in the reaction between biomolecules is observed. This response is measured in response units (RU): 1 RU = 1 pg protein / mm2 = 1 x 10-6 RIU (refractive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/01G01N21/41
Inventor 王艾段震
Owner 上海陶术生物科技有限公司