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A kit, the technology of acetonitrile, applied in the medical field, can solve the problem that there is no sensitive and specific biomarker for assessing the late recurrence risk of atrial fibrillation catheter ablation

Active Publication Date: 2019-06-21
THE FIRST PEOPLES HOSPITAL OF CHANGZHOU
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] With the continuous understanding of the pathogenesis of atrial fibrillation, the harms related to atrial fibrillation and the restoration of sinus rhythm in patients with atrial fibrillation have gradually been paid attention to, and there are still no sensitive and specific biomarkers for assessing the risk of late recurrence after catheter ablation of atrial fibrillation Therefore, there is an urgent need for experts and scholars in the medical field to jointly study a method for evaluating late recurrence after catheter ablation of atrial fibrillation, which is easy to measure and has high specificity. Chemotherapy (such as combined surgical treatment on the basis of circumpulmonary vein isolation, etc.)

Method used

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Embodiment 1

[0024] Example 1: Clinical research on late recurrence and plasma TMAO after catheter ablation of atrial fibrillation

[0025] 1. Case selection

[0026] A total of 60 patients with atrial fibrillation who were about to undergo catheter ablation for the first time were selected, and the recurrence of atrial fibrillation was followed up in March, June, September, and December respectively, and they were divided into non-late recurrence group and postoperative recurrence group ; 30 patients with paroxysmal supraventricular tachycardia were selected as the control group. [Exclusion criteria: previous history of atrial fibrillation ablation; presence of left atrial thrombus; presence of anticoagulation contraindications; history of myocardial infarction within six months; congestive heart failure; severe chronic organic diseases; hyperthyroidism; pregnancy; mental illness abnormal】

[0027] 2. Determination results of plasma TMAO

[0028] In the morning before the operation, 3m...

Embodiment 2

[0037] Embodiment 2: the specific case in embodiment 1

[0038] patient one

[0039] 1. Clinical data

[0040] The patient, male, 53 years old, was admitted to the hospital due to "palpitations for more than half a year". Diagnosis: atrial fibrillation (paroxysmal), underwent circular pulmonary vein isolation, intraoperative matrix mapping, no left atrial low voltage area was found. Sinus rhythm was restored postoperatively. Reexamination at 3 months, 6 months, 9 months, and 12 months after the operation showed no recurrence of atrial fibrillation.

[0041] Second, the determination of plasma TMAO:

[0042] TMAO high-performance liquid chromatography tandem mass spectrometry kit assay method: (1) Collect 3ml of fasting venous blood from the patient before operation, put it in an EDTA anticoagulant vacuum tube, centrifuge at 3500r for 10min at 4°C, separate the plasma, and store it in a -80°C refrigerator. (2) Take out the kit and configure standard products: mother solutio...

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Abstract

The invention provides a kit for assessing the risk of late recurrence after catheter ablation of atrial fibrillation. The kit is used for determining the content of plasma TMAO. The recurrence risk of patients with atrial fibrillation after catheter ablation can be effectively assessed through determination of TMAO in the plasma of the patients so that doctors can assess the recurrence risk of the patients with atrial fibrillation in the late stage before the catheter ablation and then designate targeted treatment schemes to provide timely and effective treatment for the patients.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a kit. Background technique [0002] Atrial fibrillation is one of the most common arrhythmias clinically, and its incidence and prevalence gradually increase with age. Stroke, heart failure, and cardiac arrest caused by atrial fibrillation can seriously increase the mortality and disability rates, and bring a heavy medical burden. There are many treatments for atrial fibrillation, and catheter ablation is one of them. However, the late recurrence rate after catheter ablation of atrial fibrillation is as high as 25%-40%, so it is of great significance to evaluate the risk of recurrence after catheter ablation of atrial fibrillation before operation and to specify a targeted treatment plan. [0003] The pathophysiology of atrial fibrillation has not been fully elucidated, and it is now generally accepted that atrial fibrillation is produced by triggering factors for initiation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 杨玲陈子俊李皓
Owner THE FIRST PEOPLES HOSPITAL OF CHANGZHOU
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