A drug for treating ulcerative colitis
A technology for ulcerative colitis and drugs, applied in the directions of drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as poor long-term treatment effect, inability to achieve long-term prevention or treatment, and increased risk of infection and cancer.
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Embodiment 1
[0018] Example 1 Study on body weight change and survival rate of DSS-induced ulcerative colitis mice by LY3009120
[0019] Experimental method: 22-24g male C57BL / 6 mice were divided into 2 groups (8 mice in each group): Vehicle group (PBS, containing 10% DMSO and 20% cyclodextrin) and LY3009120 group (20mg / Kg mice, dissolved in PBS with 10% DMSO and 20% cyclodextrin). Feed 3% DSS (dextran sodium sulfate) every day, and inject Vehicle or LY3009120 (20mg / Kg mice) intraperitoneally every day. After seven days, withdraw DSS, continue to inject Vehicle or LY3009120 intraperitoneally, and no longer inject after 3 days. Mice are weighed every day and the death situation of mice is counted, and the test results are as follows: figure 1 and 2 shown.
[0020] Experimental results: figure 1 It shows that LY3009120 can significantly inhibit the weight loss of mice, *P figure 2 It shows that LY3009120 can significantly improve the survival rate of mice.
Embodiment 2
[0021] Example 2 Effect of LY3009120 on Colon Length of DSS-Induced Ulcerative Colitis Mice
[0022] Experimental method: 22-24g male C57BL / 6 mice were divided into 3 groups: 4 mice in the control group, 4 mice in the DMSO group, and 4 mice in the LY3009120 group. The control group was fed water every day; the Vehicle and LY3009120 groups were fed 3% DSS every day, and Vehicle or LY3009120 (20 mg / Kg mice) was injected intraperitoneally every day. Seven days later, the DSS was withdrawn, and the colon length of the mice was measured. Experimental results such as image 3 As shown, the results showed that LY3009120 could significantly inhibit DSS-induced colon shortening in mice.
Embodiment 3
[0023] Example 3 Effect of LY3009120 on DSS-induced intestinal epithelial cell barrier breakdown in ulcerative colitis
[0024] Experimental method: 22-24g male C57BL / 6 mice were divided into 3 groups: 4 mice in the control group, 4 mice in the DMSO group, and 4 mice in the LY3009120 group. The control group was fed with water every day; the Vehicle and LY3009120 groups were fed with 3% DSS every day, and the Vehicle or LY3009120 (10mg / Kg mice) was injected intraperitoneally every day. Seven days later, the DSS was removed, and the colon tissue was taken, fixed with 4% paraformaldehyde, and stained with HE . Experimental results such as Figure 4 as shown, Figure 4 It was shown that LY3009120 could significantly inhibit the damage of DSS-induced colonic epithelial cell barrier in mice.
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