Parenteral ketogenic nutrient solution and preparation method thereof

Abstract

The invention relates to a parenteral ketogenic nutrient solution and a preparation method thereof. The nutrient solution is prepared from in per 100 mL of injection water, by mass, 1.80-3.3 g of amino acid, 6.5-8.0 g of fatty substances, 0.2-0.7 g of glucose, 28.93 mg of vitamins, 327.33 mg of mineral substances, 1.32-1.49 g of an emulgator and 2.34-4.29 mmol of sodium acetate, and all the substances are dissolved in the injection water. According to the formula of the high-fat low-sugar low-amino acid nutrient solution, the nutrient solution is used for well treating intractable epilepsy andother hereditary metabolic diseases such as glucose carrier deficiency disease, pyruvate dehydrogenase deficiency disease and part of tumors and fills the gap of a parenteral ketogenic nutrient solution technology.

Description

Technical field [0001] The invention relates to a medical parenteral nutrition preparation, in particular to a ketogenic parenteral nutrition solution and a preparation method thereof. Background technique [0002] The ketogenic diet is a high-fat, low-carbohydrate diet. It was first proposed by Dr. Wilder of Mayo Clinic in 1921 and used to treat intractable epilepsy, and achieved good results (Chen Wenjie, Qin Jiong. Ketogenic diet therapy for children Research progress in the mechanism of refractory epilepsy[J]. Chinese Journal of Practical Pediatrics,2017,32(24):1912-1914.). Since then, other genetic metabolic diseases such as glucose carrier deficiency, pyruvate dehydrogenase deficiency, and some tumors (Vidali S, Aminzadeh S, Lambert B, et al. Mitochondria: the ketogenic diet-ametabolism-based therapy. Int J Biochem Cell Biol.2015;63:55-59.) and so on, have achieved good results. However, regardless of the above-mentioned patients, once gastrointestinal obstruction, intest...

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Problems solved by technology

[0006] The beneficial effects of the present invention are: the present invention is mainly used for patients who have adopted a ketogenic diet to control their diseases (such as controlling epileptic seizures) and fasting for severe gastrointestinal dysfunction (such as intestinal obstruction, active bleeding, etc.) Ordinary parenteral nutrition formulas such as high-sugar and low-fat cannot be used. The present invention can effectively maintain the blood ketone level of fasting children, avoid the onset of diseases, and ensure the total energy intake at the same time. At the same time, the present invention is a high-fat, low-sugar and low-amino acid formula, which is different from ordinary parenteral nutrition solutions with high-sugar, low-fat, and moderate amino acid formulas. For the special needs of energy-supplying nutrients, the ratio of fat emulsion in the parenteral nutrition formula is increased, the ratio of amino acids and glucose is reduced, and the requirements of vitamins and minerals are determined. It is safe and effective to use in children, and can maintain the blood of patients after infusion. Ketones are in the ideal range, blood sugar is also in the normal range, and it does not induce seizures in patients (or induce hyperlactatemia in patients with abnormal glucose metabolism), effectively solving the ...

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