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Method for improving anti-static, anti-abrasion and water lubricating performance of starch capsules

A starch capsule and wear-resistant technology, applied in the field of medical excipients, can solve the problems of unsuitable antistatic treatment of medical excipients, affecting the practical application of starch capsules, and high friction coefficient of starch film, reducing wear volume, reducing dry friction coefficient, Improve the effect of anti-static

Active Publication Date: 2019-06-28
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These antistatic means are effective, but they all use substances harmful to the human body to treat the surface of the polymer, so they are not suitable for antistatic treatment of medical accessories
[0005] In addition, the shortcomings of starch film, such as high friction coefficient, high wear rate and poor water lubricity, have seriously affected the practical application of starch capsules, and there is no better solution at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] In a specific embodiment of the present invention, the preparation method of the starch capsule preferably comprises the following steps:

[0029] Mixing starch, small molecule polyol, gelling agent, gelling agent and water for gelatinization to obtain starch glue;

[0030] After the starch glue solution is defoamed, the starch capsules are obtained by dipping in glue, drying, shelling, cutting and fitting in sequence.

[0031] In the present invention, the gelatinization temperature is preferably 90°C. The present invention has no special requirements on the gelatinization time, as long as a uniform starch glue can be obtained; the present invention preferably uses a water bath heat preservation method for the starch glue Carry out defoaming; the temperature of the water bath insulation is preferably 50°C, and the time is preferably 20min. In the present invention, there is no special requirement on the method of dipping in glue, and the capsule mold well-known to tho...

Embodiment 1

[0035] Accurately weigh 20g of potato oxidized starch, 2g of glycerin, 0.5g of carrageenan, 0.4g of KCl, and 100mL of distilled water, mix well, place in a water bath at 90°C, and gelatinize under mechanical stirring at 200r / min. The gelatinized starch glue solution was poured into a flat pan for casting to form a film, and dried in an oven at 40° C. for 6 hours to obtain a dried starch film.

[0036] Comparative test: no glycerin was added, other conditions were the same as the above scheme, and a blank starch film was obtained.

[0037] Performance test: Cut the dried starch film into a size of "4cm×4cm", stick copper tape on the back, form a triboelectric nanogenerator (TENG) with PTFE electrodes, and measure its electrical output; take another starch film and test it on a friction testing machine Dry friction coefficient and wet friction coefficient, and the wear volume was measured with a three-dimensional profiler.

[0038] The experimental results show that the output ...

Embodiment 2

[0041] Accurately weigh 17g of corn acetate starch, 0.5g of sorbitol, 0.3g of xanthan gum, 0.1g of konjac gum, 0.3g of KCl, 100mL of distilled water, stir well, mechanically stir, heat to 90°C to gelatinize, cast The method was used to form a film, and dried in an oven at 40°C for 6 hours to obtain a starch film.

[0042] Comparative test: no sorbitol was added, other conditions were the same as the above scheme, and a blank starch film was obtained.

[0043] According to the method in Example 1, the electrical output, dry and wet friction coefficient and wear volume of the TENG of the starch film were tested. The experimental results show that the output current of the starch film TENG prepared in this example is 58% lower than that of the blank starch film TENG, and has good antistatic performance. Lubrication level, the wear volume was reduced by 87%, indicating that the starch film has good wear resistance and water lubricity.

[0044] According to the method in Example ...

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Abstract

The invention relates to the field of medical accessories, and provides a method for improving the anti-static, anti-abrasion and water lubricating performance of starch capsules. A micromolecular polyhydroxy compound is added into preparation raw materials of the starch capsules, the hygroscopicity of starch membranes is improved by adding the micromolecular polyhydroxy compound, bound water on the surfaces of the starch membranes moves inwards, the content of the bound water on the surfaces of the starch membranes is reduced, thus, the electric charge quantity generated on the surfaces of the starch membranes is reduced, and the anti-static purpose is achieved; meanwhile, as the content of bound water on the surfaces of capsule shells is reduced, the space hindrance of the starch capsules in the water-containing environment can be reduced, and the water lubricity of the starch capsules is improved; the micromolecular polyhydroxy compound enters the starch membranes, hydrogen bonds are formed between the micromolecular polyhydroxy compound and starch molecules, relative sliding between starch molecular chains becomes easier, thus, the dry friction coefficient of the starch membranes can be reduced, and the purposes of reducing friction and resisting abrasion are achieved.

Description

technical field [0001] The invention relates to the technical field of medical auxiliary materials, in particular to a method for improving the antistatic, wear-resistant and water-lubricating properties of starch capsules. Background technique [0002] Starch capsules are green, cheap, degradable, non-toxic and harmless new medical excipients developed in recent years to replace gelatin capsules. Since 2016, medicinal starch capsules represented by Hunan Erkang Pharmaceuticals have been born, and have quickly become the new favorite of the pharmaceutical industry. In recent years, the research and development of starch capsules has also become a hot spot in the scientific research community. According to reports, the research and development units of starch capsules include Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Process Research, South China University of Technology, and the research group of Professor Yu Lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L3/10C08L3/06C08L3/02C08L71/02C08L3/08C08L5/00C08K5/053C08J5/18
Inventor 王道爱王楠楠周峰
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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