Composition for protein l-isoaspartate methyltransferase activation
A technology of aspartic acid methyl and protein, which is applied in the direction of drug combination, cosmetics, food science, etc., and can solve problems such as rough skin, skin irritation, and skin aging
Active Publication Date: 2019-07-16
SUNTORY HLDG LTD
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, internal factors such as the decline of various skin functions with age, and external factors such as ultraviolet exposure can cause skin aging phenomena such as wrinkles, sagging, lack of elasticity, dullness, and rough skin.
In particular, the skin damage caused by ultraviolet rays, which is the main external factor, is cumulative and accelerates the progress of skin aging due to aging, leading to a deeper aging state, which has a significant impact on the skin.
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment
[0173] Hereinafter, examples which can more specifically describe the present invention are shown. In addition, this invention is not limited only to these Examples.
[0174] The protein extraction reagent used in the following experiments was manufactured by Thermo Company, and the trade name was M-PER (registered trademark) Mammalian Protein Extraction Reagent. In the test example, the measurement of the significant difference was done by the Student's t-distribution test.
manufacture example 1
[0257] lotion
[0258] Stir the raw materials listed in Table 6 until they are uniform, and prepare a lotion for PIMT activation.
[0259] [Table 6]
[0260]
manufacture example 2
[0262] lotion
[0263] The raw materials described in Table 7 were stirred until uniform, and an emulsion for PIMT activation was prepared.
[0264] [Table 7]
[0265]
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The purpose of the present invention is to provide: a composition for protein L-isoaspartate methyltransferase (PIMT) activation with which it is possible to activate PIMT; a novel indicator for evaluating skin restoration or repair activity; a novel indicator for evaluating skin anti-aging activity; and a method for evaluating skin restoration or repair activity and a method for evaluating skin anti-aging activity, etc., in which these indicators are used, respectively. This composition for protein L-isoaspartate methyltransferase (PIMT) activation contains an extract of one or more plants selected from the group consisting of: plants of the family Betulaceae, genus Betula; plants of the family Vitaceae, genus Vitis; plants of the family Fabaceae, genus Glycine; plants of the family Cannabaceae, genus Humulus; plants of the family Labiatae; plants of the family Rutaceae, genus Citrus; plants of the family Acoraceae, genus Acorus; plants of the family Asteraceae, genus Arnica; and plants of the family Rosaceae, genus Prunus.
Description
technical field [0001] The present invention relates to a composition for activating protein L-isoaspartate methyltransferase (PIMT). The present invention also relates to a composition for promoting restoration or repair of a protein containing an isomerized amino acid. The present invention further relates to a method for activating PIMT, and a method for promoting restoration or repair of proteins containing isomerized amino acids. The present invention also relates to a method for evaluating skin restoration or repair activity, a method for evaluating skin anti-aging activity, and a method for screening active ingredients for activation of PIMT present in skin and the like. Background technique [0002] Maintaining healthy and youthful skin is a high concern for most people. However, internal factors such as the decline of various skin functions with age, and external factors such as ultraviolet exposure can cause skin aging phenomena such as wrinkles, sagging, lack of...
Claims
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IPC IPC(8): A61K8/9789A61K8/9794A61K36/185A61K36/28A61K36/53A61K36/535A61K36/537A61K36/736A61K36/752A61K36/87A61K36/882A61P17/00A61P43/00A61Q19/08A23L33/105
CPCA23L33/105A61K8/9789A61K8/9794A61K36/185A61K36/28A61K36/53A61K36/535A61K36/537A61K36/736A61K36/752A61K36/87A61K36/882A61P17/00A61P43/00A61Q19/08
Inventor 北川小百合
Owner SUNTORY HLDG LTD
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