A kind of cefuroxime axetil solid preparation and preparation technology thereof

Abstract

The invention discloses a solid preparation of cefuroxime axetil, which comprises an active ingredient of a drug, cefuroxime axetil, and an auxiliary material, wherein the auxiliary material includes a lubricant, and the lubricant is selected from glyceryl behenate, sodium stearyl fumarate, and talcum powder At least one of the preservative-free. The cefuroxime axetil product of the original research company is added with preservatives such as methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, and hydrogenated vegetable oil. As people pay more and more attention to the safety of food and drugs, this The safety of several preservatives and hydrogenated vegetable oils is controversial. Therefore, in order to eliminate patients' concerns about preservatives and hydrogenated vegetable oils and reduce potential safety risks, the present invention avoids the use of preservatives through research, and adopts glyceryl behenate instead of hydrogenated vegetable oils, and obtains a patent with British kudzu Cefuroxime Axetil Tablets produced by LansuSmithKline Co., Ltd. has the same bioavailability as the drug, and the drug is suitable for commercial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a cefuroxime axetil solid preparation and a preparation process thereof. Background technique [0002] Cefuroxime axetil is a semi-synthetic second-generation cephalosporin drug that can be used orally and intravenously. The bactericidal activity of cefuroxime axetil in vivo comes from its parent compound cefuroxime. Cefuroxime is a well-characterized and effective antibacterial drug with a broad antibacterial spectrum and bactericidal activity against a wide range of common pathogens, including β-lactamase-producing bacteria. Cefuroxime has good stability to bacterial β-lactamases and is therefore effective against many strains resistant to ampicillin and amoxicillin. It is suitable for the treatment of infections caused by sensitive bacteria, including: lower respiratory tract infections such as acute bronchitis and acute exacerbation of chronic bronchitis...

AI Technical Summary

Problems solved by technology

On the one hand, the addition of too many excipients in the drug may also lead to safety disputes. On the other hand, because it contains hydrogenated vegetable oil, which is a mixture of saturated fatty acid triglycerides, a small amount of trans Fatty acids, generally speaking, trans fatty acids are more harmful to the human body than saturated fatty acids, and there is some controversy about their safety

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