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A method for extracting rutin and scopoletin from tobacco leaves

A technology of scopolamine and rutin, which is applied in the field of extracting rutin and scopolamine, can solve the problems of excessive output and inventory of tobacco leaves, high price and cost, and no extraction of rutin and scopolamine, so as to improve the utilization rate , Improve the extraction rate and reduce the production cost

Active Publication Date: 2022-03-15
CHINA TOBACCO HUNAN INDAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The price cost is relatively high, mainly due to the price of raw materials, but the existing tobacco leaf production and inventory are relatively excessive, and there is no method for extracting rutin and scopolamine from tobacco leaves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 100kg tobacco leaf raw material, add 500L petroleum ether after crushing, reflux extraction for 3h, filter with ceramic membrane to obtain filtrate I and filter residue I, filtrate I is evaporated to dryness under reduced pressure and recover petroleum ether to obtain 4.62kg extract I; heat and melt in a water bath at 50°C, Then add 20 L of chloroform for extraction to obtain chloroform extract I.

[0030] Take filter residue I and add 400L of 70% ethanol solution, extract at room temperature for 4h, filter through ceramic membrane (to obtain 320L ethanol filtrate), then add 400L of 70% ethanol solution (in filter residue) to extract under reflux at 90°C for 3h, filter through ceramic membrane (to obtain 360L ethanol filtrate) Filtrate), combined filtrates to obtain 680L filtrate II, and concentrated under reduced pressure to 30L to obtain concentrated solution I, and placed it at 2-4°C for 11h, filtered through a ceramic membrane to obtain filtrate III and 6.64kg ...

Embodiment 2

[0033] Weigh 200kg of tobacco leaf raw material, add 900L of petroleum ether after crushing, reflux and extract for 4 hours, filter with ceramic membrane to obtain filtrate I and filter residue I, filtrate I is evaporated to dryness under reduced pressure and recover petroleum ether to obtain 9.88kg of extract I; heat and melt in a water bath at 50°C, Then add 35 L of chloroform for extraction to obtain chloroform extract I.

[0034] Take filter residue I and add 600L of 75% ethanol solution, extract at room temperature for 4h, filter with ceramic membrane (to obtain 500L ethanol filtrate), then add 600L of 75% ethanol solution (in filter residue) to reflux at 80°C for 2.5h, filter with ceramic membrane (to obtain 550L ethanol filtrate), combined filtrates to obtain 1050L filtrate II, and concentrated under reduced pressure to 50L to obtain concentrated solution I, and placed it at 2-4°C for 11h, filtered through ceramic membrane to obtain filtrate III and 13.71kg solids; solid...

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Abstract

The invention relates to a method for extracting rutin and scopoletin from tobacco leaves. The steps include petroleum ether reflux extraction, filtration, extraction, ethanol extraction of filter residue, filtration concentration, crystallization, chloroform extraction of crystals, and silica gel column purification on the filtrate to obtain Hyoscypolamine, the filter residue was extracted with dimethyl sulfoxide and recrystallized to obtain rutin. The simultaneous extraction of rutin and scopolamine effectively improves the utilization rate of tobacco leaves and reduces production costs. The low-temperature crystallization treatment effectively prevents the chlorogenic acid from promoting the degradation of rutin during the extraction process, and is also conducive to improving the extraction rate of scopoletin.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of natural product processing and relates to a method for extracting rutin and scopolamine from tobacco leaves. Background technique: [0003] my country is a big tobacco country, and the output of tobacco leaves and cigarettes ranks first in the world. The tobacco industry occupies an important position in my country's national economy. At present, my country's annual tobacco planting area is about 1 million hectares, and the tobacco leaf output is 1.5 to 1.7 million tons. The total output of tobacco leaves in 2003 was 1.556 million tons. Chemical substances in tobacco can be divided into minerals, carbohydrates, nitrogenous compounds, organic acids and their derivatives, pigments, oligosaccharides, polysaccharides, and pentosan compounds. The content of organic acids in tobacco is very rich, mainly dibasic acids and tribasic acids, such as malic acid, citric acid, oxalic acid, succinic acid, fuma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/16C07H17/07C07H1/08
CPCC07D311/16C07H17/07C07H1/08
Inventor 范胜兴梁兵张志文
Owner CHINA TOBACCO HUNAN INDAL CORP