A method and system for regulating pressure in a chemical shower room in a biosafety laboratory

Abstract

The invention discloses a pressure regulating system and method for a chemical shower room in a biological safety laboratory. The high-level biosafety laboratory is a special laboratory for research on the prevention and control of severe pathogens. The strict negative pressure requirements and directional airflow control in the core area of ​​the laboratory are important technical measures to ensure biosafety. It is necessary to pass through the chemical shower, and the chemical spray in the chemical shower will disinfect and sterilize the surface of the protective clothing of the experimental personnel entering and leaving. Therefore, there will be the following obvious airflow disturbances in the chemical shower, which will seriously affect the negative pressure control of the chemical shower: switch chemical The door of the shower room; the discharge of respiratory air supply for personnel protective clothing; the spraying of chemical shower liquid; 1 to 3 people entering the chemical shower room are not fixed; the instability of the characteristic curve of the control valve. The complex airflow disturbance conditions and related influencing factors in the chemical shower room make the negative pressure control scheme of the chemical shower room face severe challenges.

Description

technical field [0001] The invention relates to the technical field of pressure regulation, in particular to a method and system for regulating the pressure of a chemical shower in a biosafety laboratory aimed at negative pressure regulation in a chemical shower in a high-level biosafety laboratory. Background technique [0002] Wuhan National Biosafety Laboratory is the first high-level biosafety (Level 4) laboratory in my country. The high-level biosafety laboratory is a special laboratory for research on the prevention and control of severe pathogens. The core area of ​​the laboratory has strict negative pressure requirements and directional airflow Control is an important technical measure to ensure biological safety. Personnel entering and leaving the laboratory need to be disinfected and sterilized by spraying chemical liquid in the chemical shower room. The space in the chemical shower room is small, and the complex airflow interference conditions in the chemical shower...

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Problems solved by technology

[0002] Wuhan National Biosafety Laboratory is the first high-level biosafety (Level 4) laboratory in my country. The high-level biosafety laboratory is a special laboratory for research on the prevention and control of severe pathogens. The core area of ​​the laboratory has strict negative pressure requirements and directional airflow Control is an important technical measure to ensure biological safety. Personnel entering and leaving the laboratory need to be disinfected and sterilized by spraying chemical liquid in the chemical shower room. The space in the chemical shower room is small, and the complex airflow interference conditions in the chemical shower room and related multiple influencing factors make Negative pressure regulation in chemical showers faces serious challenges

[0003] Previously, in my country's P3 laboratory, biological safety cabinets, fume hoods and animal cage ventilation control have encountered similar control problems, but the interference factors are relatively single, and the occurrence space is relatively large. Through simple prediction or The feedback control of the operation signal of the equipment can basically solve the problem. At present, the Venturi valve is generally used for feedback control.

[0004] In view of the multiple and complex interference factors, the relatively high requirements for negative pressure control, the small space of the negative pressure control room, and the high requirements for system airtightness, the negative pressure control of chemical showers in high-level biosafety laboratories is somewhat challenging.

[0005] The existing problem is: when the chemical shower is isolated from the positive pressure changing room and the biosafety laboratory, negative pressure must be maintained, and the negative pressure gradient between the biosafety laboratory, the chemical shower, and the positive pressure changing room is -90pa , -75pa, -50pa, 0pa; the biosafety laboratory is a place used for severe virus or bacterial experiments. When entering the biosafety laboratory from the chemical shower or entering the chemical shower from the biosafety laboratory, the staff must pay attention to the chemical Clean and disinfect the shower room with chemical agents. When disinfecting the chemical shower room, spray compressed air at 30L / min and spray liquid medicine at 15L / min. In order to maintain the relative pressure in the chemical shower room, it is necessary to increase the opening value of the exhaust valve and improve the pumping rate. Gas volume; when entering the chemical shower room, the personnel need to supply air for the protective clothing to breathe, and the gas supply in the chemical shower room should be increased by 60m 3 / h*3 people breathe gas, in order to maintain the relative pressure of the chemical shower room, it is necessary to increase the opening value of the exhaust valve and increase the pumping volume; when the isolation between the biosafety laboratory, the chemical shower room and the positive pressure changing room When the door is opened and then closed, the pressure difference between the chemical shower room and the positive pressure changing room decreases first, and the opening of the regulating valve decreases, and then maintains a greater negative pressure to recover quickly, which is prone to positive pressure, or biosafety experiments. Compared with the chemical shower room, the pressure difference decreases first, the speed of the large exhaust fan increases, and the opening of the pressure regulating valve in the chemical shower room decreases. After being isolated from the biosafety laboratory, it is difficult to open the large pressure regulating valve immediately. Positive pressure is easily generated in the locker room instantly, resulting in the failure of biosafety isolation

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