Preparation method of organic-inorganic hybrid monolithic column

A monolithic column, inorganic technology, applied in the field of detection, can solve the problems of reduced stability and mechanical properties, intolerant of organic solvent swelling, poor thermal stability, etc., to achieve enhanced mechanical properties, good thermal stability, good porosity. Effect

Inactive Publication Date: 2019-08-06
吴培建
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Problems solved by technology

[0009] The technical problem to be solved by the present invention: the swelling and shrinking effect of polymer monolithic columns in organic solvents will reduce their stability and mechanical properties to a certain extent, because the skel

Method used

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Embodiment Construction

[0034] In parts by weight, weigh 5~10 parts of copper perchlorate, 10~20 parts of melamine, 1~2 parts of citric acid, 20~40 parts of N,N-dimethylformamide, and add the copper perchlorate , Melamine and citric acid are added to N,N-dimethylformamide, stir and mix at 180~200r / min for 10~12min at room temperature, and let stand for 20~24h to obtain a copper ion mixture. Place the copper ion mixture In an ultrasonic dispersing machine, ultrasonically vibrate for 15-20min under the condition of 400~500W to obtain copper metal organic gel; then weigh 20~30 parts of ethyl orthosilicate and 8~12 parts by weight. Anhydrous ethanol, 16~24 parts of 25% by mass ammonia water, 20~30 parts of deionized water, add anhydrous ethanol and ammonia to deionized water, and stir at 120~160r / min for 10~12min at room temperature to obtain alcohol Ammonia hydrolysis solution, add 1 / 3 ethyl orthosilicate to 1 / 3 alcohol ammonia hydrolysis solution, stir at 240~280r / min for 30~40min under refrigerated con...

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Abstract

The invention relates to a preparation method of an organic-inorganic hybrid monolithic column, belonging to the technical field of detection. The organic-inorganic hybrid monolithic column is obtained by using methyl methacrylate and polyethylene glycol as organic materials and adding a copper metal organic gel. Due to a special structure, the polyethylene glycol has little effect on biological macromolecules such as proteins and the like, and is a recognized biocompatible material. As a novel pore-forming template, the metal organic gel is used to prepare a macroporous transparent organic polymer material which is in a gel state of a metal organic framework. The metal-organic framework is a porous material with a periodic network structure formed by an organic ligand and metal ions through a self-assembly process. The metal-organic framework is also known as coordination polymer. The metal-organic gel is simple to prepare, has the characteristics of good porosity, structural diversity, good chemical stability and thermal stability, and the metal in gel can effectively improve the rigidity of the monolithic column and enhance the mechanical properties of the monolithic column.

Description

Technical field [0001] The invention relates to a preparation method of an organic-inorganic hybrid monolithic column, which belongs to the technical field of detection. Background technique [0002] Currently, high-performance liquid chromatography-ultraviolet or mass spectrometry (HPLC-UV / MS) has become the main method of in vivo drug analysis. However, the rapid and accurate chromatographic analysis of drug components in the body has been facing the bottleneck of the pretreatment of body fluid samples (especially blood samples). In recent years, many research fields such as pharmacology, clinical pharmacology, and clinical drug treatment testing are facing an increasingly large number of physiological body fluid samples. The development of rapid and efficient enrichment and purification methods for target components in body fluids It is particularly important. [0003] Solid phase extraction (SPE) has the advantages of simple operation, flexible use, high recovery rate, less s...

Claims

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Application Information

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IPC IPC(8): B01J20/283B01D15/20B01J20/30
CPCB01D15/206B01J20/283B01J2220/86
Inventor 吴培建
Owner 吴培建
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