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Application of FAM172A autoantibody detection reagent in preparing lung cancer screening kit

A technology of FAM172A and autoantibodies, which is applied in biological testing, measuring devices, material inspection products, etc., can solve the problems of no FAM172A protein and no lung cancer, and achieve good application prospects, low patient harm, and effective screening Check the effect

Active Publication Date: 2019-08-09
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no relevant reports on FAM172A protein autoantibodies, and no prior art related to lung cancer.

Method used

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  • Application of FAM172A autoantibody detection reagent in preparing lung cancer screening kit
  • Application of FAM172A autoantibody detection reagent in preparing lung cancer screening kit
  • Application of FAM172A autoantibody detection reagent in preparing lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Relationship between FAM172A autoantibodies in plasma and lung cancer

[0027] 1. Clinical data

[0028] Select 30 cases of lung cancer patients, 29 cases of benign lung diseases (tuberculosis, hamartoma and other non-malignant tumors), and 30 cases of healthy controls. The basic information is as follows:

[0029]

[0030]

[0031] 2. Detection principle

[0032] HuProt TM The FAM172A protein is immobilized on the human protein custom chip. After incubation with serum, the FAM172A autoantibodies (mainly including IgG, IgM antibodies, and some other types of antibodies) in the serum will bind to it, and the unbound antibodies and other proteins will be removed by washing. Then use anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, red) and anti-human IgG fluorescent secondary antibody (cy3-labeled, green) to detect, and read the signal through a fluorescent scanner. The strength of the signal is related to the affinity and quantity o...

Embodiment 2

[0046] Embodiment 2 The composition of detection kit of the present invention and its application method

[0047] 1. Kit composition

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PUM

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Abstract

The invention relates to the field of in vitro diagnostic reagents, and particularly relates to an application of an FAM172A autoantibody detection reagent in preparing a lung cancer screening kit. The scheme of the invention finds for the first time that the autoantibody level of FAM172A protein in the serum of lung cancer patients is significantly higher than that of healthy patients. The schemeof the invention uses a reagent for detecting an FAM172A protein autoantibody to prepare the lung cancer screening kit, and can realize the effective screening of lung cancer.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of FAM172A autoantibody detection reagents in the preparation of lung cancer screening kits. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. Its morbidity and mortality are increasing year by year. Currently, the incidence rate ranks first in the world, which seriously threatens human health and life. [0003] Lung cancer is a disease that is good at concealment. It often shows clinical symptoms when the disease develops to an advanced stage. 70-80% of lung cancer patients are already in the middle or late stage when they are diagnosed with lung cancer symptoms. The best cure time, five-year survival rate is low. For patients with early lung cancer, timely treatment can greatly improve the 5-year survival rate and quality of life of the patients. Therefore, early diagnosis and effective screening of lung canc...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68G01N33/533G01N33/535
CPCG01N33/533G01N33/535G01N33/57423G01N33/57484G01N33/6854G01N2333/4746
Inventor 张立李为民
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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