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A kind of passivated black phosphorus material and its preparation method and application

A black phosphorus and peptide chain technology, applied in the field of passivated black phosphorus materials, can solve the problems of reducing the biocompatibility of black phosphorus materials, and achieve the effect of improving the film penetration ability and improving the stability.

Active Publication Date: 2021-04-02
BEIJING INST OF NANOENERGY & NANOSYST
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  • Abstract
  • Description
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Problems solved by technology

[0005] The purpose of the present invention is to overcome the problem of reducing the biocompatibility of black phosphorus materials in the introduction of passivating agents in the existing passivation black phosphorus method, and to provide a passivation effect and good biocompatibility. Passivated black phosphorus material and its preparation method and the application of the passivated black phosphorus material in drug delivery or photothermal therapy

Method used

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  • A kind of passivated black phosphorus material and its preparation method and application
  • A kind of passivated black phosphorus material and its preparation method and application
  • A kind of passivated black phosphorus material and its preparation method and application

Examples

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Effect test

Embodiment 1-4 and comparative example 1

[0059] Preparation of passivated black phosphorus materials: disperse nano-scale black phosphorus sheets or black phosphorus quantum dots (BP) (Xianfeng Nano Material Technology Co., Ltd., model: 101927) in N-methylpyrrolidone (NMP) to obtain uniformly dispersed solution, the freeze-dried polypeptide phenylalanine-lysine-lysine (FKK) was added to the black phosphorus nanosheet NMP solution, and ultrasonic treatment (ultrasonic power 100W, temperature 5°C, time 2h) made FKK effective Modified on the surface of BP, the remaining free polypeptide was removed by centrifugation (centrifugation at 12000rpm for 15min), and the separated precipitate was resuspended by ultrasonication for 2h to obtain the desired uniform mixture of passivated black phosphorus material (BP@FKK) solution.

[0060] Specifically, the preparation of Examples 1-4 and Comparative Example 1 (without addition of polypeptide) was carried out according to the composition described in the following Table 1 by the ...

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Abstract

The invention relates to the field of black phosphorus materials and discloses a passivated black phosphorus material, a preparation method of the black phosphorus material and application in drug delivery or photothermal therapy. The passivated black phosphorus material is black phosphorus modified by a peptide chain, and the peptide chain at least comprises lysine and / or phenylalanine. The passivated black phosphorus material has high stability, good biocompatibility, excellent fluorescence performance and photothermal effect performance, and good cell penetration capability.

Description

technical field [0001] The invention relates to the field of black phosphorus materials, in particular to a passivated black phosphorus material and a preparation method and application of the black phosphorus material. Background technique [0002] Black phosphorus is one of the most stable allotropes of phosphorus. It is a two-dimensional material with a direct energy band structure, and its band gap can be adjusted from 0.3eV to 2eV with the layer thickness. Black phosphorus is also a semiconductor material, with electron mobility exceeding that of transition metals, up to 1000 cm 2 V -1 the s -1 above. The unique wrinkled structure of black phosphorus endows it with a larger specific surface area than other two-dimensional materials. In addition, black phosphorus has the advantages of good photothermal performance, degradability in physiological environment, and low biological toxicity. Black phosphorus has attracted extensive attention in the fields of biomedicine, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/00A61K41/00A61K47/04
CPCA61K41/0052A61K47/02C01B25/006C01P2002/80C01P2002/82C01P2002/84C01P2002/85
Inventor 李舟王华英胡宽王婵李喆李虎
Owner BEIJING INST OF NANOENERGY & NANOSYST
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