Resveratrol nanoethosome and preparation method and application thereof

A technology of resveratrol and ethosomes, applied in liposome delivery, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of unstable physical and chemical properties of resveratrol monomer, prone to photochemical reactions, and affecting biological utilization To achieve the effect of good drug effect, good permeability and good skin permeability

Active Publication Date: 2019-09-06
HUNAN UNIV OF HUMANITIES SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the physical and chemical properties of resveratrol monomer itself are extremely unstable, prone to phot

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing resveratrol nano-etosomes, comprising the following steps: S1 weighs soybean lecithin, sucrose esters, resveratrol, and Tween-80 and dissolves them in ethanol; S2 dissolves the mixed solution of step S1 in Stir at a speed of 800r / min in a water bath at 30°C for 5 minutes; S3 seal the solution stirred in step S2, and then inject 60mL of distilled water with a syringe, so that the mass percentage of soybean lecithin is 1.5%, and the content of resveratrol The mass percentage composition is 0.18%, the mass percentage composition of ethanol is 28%, the mass percentage composition of sucrose ester is 0.08%, the mass percentage composition of Tween-80 is 1.2%; S4 the mixed solution of step S3 again Stirring at a speed of 800 r / min for 8 minutes; S5 ultrasonicating the liquid in step S4 for 2.2 minutes in an ice bath; S6 filtering with a microfiltration membrane to obtain resveratrol nano-etosomes.

Embodiment 2

[0033] A method for preparing resveratrol nano-etosomes, comprising the following steps: S1 weighs soybean lecithin, sucrose esters, resveratrol, and Tween-80 and dissolves them in ethanol; S2 dissolves the mixed solution of step S1 in Stir at a speed of 1500r / min in a water bath at 30°C for 1 min; S3 seal the solution stirred in step S2, and then inject 80 mL of distilled water with a syringe so that the mass percentage of soybean lecithin is 1.5%, and the content of resveratrol The mass percentage composition is 0.22%, the mass percentage composition of ethanol is 32%, the mass percentage composition of sucrose ester is 0.12%, the mass percentage composition of Tween-80 is 1.7%; S4 is mixed solution of step S3 again Stirring at a speed of 1500 r / min for 4 min; S5 ultrasonicating the liquid in step S4 for 2.5 min in an ice bath; S6 filtering with a microfiltration membrane to obtain resveratrol nano-etosomes.

Embodiment 3

[0035] A method for preparing resveratrol nano-etosomes, comprising the following steps: S1 weighs soybean lecithin, sucrose esters, resveratrol, and Tween-80 and dissolves them in ethanol; S2 dissolves the mixed solution of step S1 in Stir at a speed of 1000r / min for 2min in a water bath at 30°C; S3 seal the solution stirred in step S2, and then inject 70mL of distilled water with a syringe, so that the mass percentage of soybean lecithin is 1.5%, and the content of resveratrol The mass percentage composition is 0.2%, the mass percentage composition of ethanol is 30%, the mass percentage composition of sucrose ester is 0.1%, the mass percentage composition of Tween-80 is 1.5%; S4 is mixed solution of step S3 again Stirring at a speed of 1000r / min for 2 min; S5 ultrasonicating the liquid in step S4 for 2.5 min under ice bath conditions; S6 filtering with a microfiltration membrane to obtain resveratrol nano-etosomes.

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Abstract

The invention relates to the field of chemical preparations, and in particular, relates to a resveratrol nanoethosome and a preparation method and an application thereof. The preparation method comprises the following steps: S1, weighing soybean lecithin, a stabilizer and resveratrol, and dissolving into ethanol; S2, stirring the mixed solution of the step S1 under a condition of 30-35 DEG C waterbath at the rotational speed of 800-1500 r/min for 1-5 min; S3, sealing the solution obtained after stirring in the step S2, and then adding 60-80 mL of distilled water; S4, stirring the mixed solution of the step S3 at the rotational speed of 800-1500 r/min for 2-8 min; S5, carrying out ultrasonic treatment of the liquid of the step S4 for 2.2-2.5 min under a condition of ice bath; and S6, filtering to obtain the product. The resveratrol nanoethosome prepared by compound sucrose ester and a Tween-80 stabilizer has the advantages of high encapsulation efficiency and better stability.

Description

technical field [0001] The invention relates to the field of chemical preparations, in particular to a resveratrol nano-etosome and its preparation method and application. Background technique [0002] The chemical name of Resveratrol (Res for short) is (E)-3,5,4-trihydroxystilbene. Also known as stilbene triphenols, polyphenolic compounds. Molecular formula C 14 h 12 o 3 , relative molecular mass 228.25. In 1940, Japanese researchers isolated resveratrol from the roots of plants. In 1963, scientists first purified resveratrol from the traditional Chinese medicine Polygonum cuspidatum. Now resveratrol has been found in more than 70 kinds of plants. The plants containing resveratrol are usually medicinal plants, such as cassia, knotweed, etc.; some are food, such as grapes, peanuts, etc. Grapes contain the highest resveratrol content, and red wine has always been the main way for humans to ingest resveratrol. The famous "French Paradox" phenomenon appeared in the 20th ...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/49A61K8/60A61K8/14A61Q19/08A61K9/127A61K31/05A61K47/10A61K47/26A61P39/06A61P35/00A61P9/14A61P9/00A61P1/16A61P37/04
CPCA61K8/347A61K8/34A61K8/4993A61K8/60A61K8/14A61Q19/08A61K9/1271A61K31/05A61K47/10A61K47/26A61P39/06A61P35/00A61P9/14A61P9/00A61P1/16A61P37/04
Inventor 王双辉金晨钟徐铁胡一鸿张雪娇毛炳雄包生福
Owner HUNAN UNIV OF HUMANITIES SCI & TECH
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