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Micro-fluidic biochip scanning signal detection device

A technology for scanning signals and biochips, applied in measurement devices, instruments, fluorescence/phosphorescence, etc., can solve the problems of uneven distribution of measured signals, inconsistent lengths, etc., to improve length consistency and accuracy, and reduce unevenness. , the effect of speeding up the calculation

Active Publication Date: 2019-09-06
TIANJIN RES INST FOR ADVANCED EQUIP TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] During the scanning detection process of the microfluidic biochip with high precision and high sensitivity, the length of the extracted signal of the induced fluorescence in the detection area (T area) and the quality control area (C area) is inconsistent, and the measured signal in the area is inconsistent. For problems such as uneven distribution, a microfluidic biochip scanning signal detection device is provided in the embodiment of the present application

Method used

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  • Micro-fluidic biochip scanning signal detection device

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Embodiment 1

[0057] The detection device of the microfluidic biochip scanning signal based on wavelet transform of the present invention mainly includes: the acquisition and filtering module of the original scanning signal, the wavelet transform module of the scanning signal, the equal time length determination module of the scanning signal, the signal extraction module, the signal The homogenization reconstruction module and the concentration calculation module of the detected object, such as Figure 5 As shown, the specific steps are as follows image 3 shown.

[0058] In the present invention, the main processing process of the acquisition and filtering module of the original scanning signal is: using a photofluorescence detector to perform scanning sensing acquisition of the induced fluorescence signal on the microfluidic biochip to be tested and the flow channel , and amplify it, the amplified original scanning signal is denoted as f N (t), such as image 3 As shown in (a), after t...

Embodiment 2

[0085] In order to make the purpose, technical solution and advantages of the present invention clearer, a wavelet transform-based microfluidic biochip scanning signal detection device of the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0086] see figure 1 , the laser is focused on the surface of the microfluidic biochip and scanned along the flow channel. The scanning process is "flow channel-detection area (T area)-flow channel-quality inspection area (C area)-flow channel". There is an analyte marked with a fluorescent dye on the detection area, and a reference object marked with a fluorescent dye on the quality inspection area, and the induced fluorescence is received by the fluorescent detector through the confocal optical path structure.

[...

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Abstract

The invention discloses a micro-fluidic biochip scanning signal detection device. The micro-fluidic biochip scanning signal detection device comprises an acquisition and filtering module of an original scanning signal for acquiring scanning signals of induced fluorescent signals on a micro-fluidic biochip to-be-tested area and a flow channel; a wavelet transform module of the scanning signals foracquiring the lengths of the scanning signals in T and C areas; an equal time length determination module of the scanning signals for acquiring the lengths of effective signals of the T area and the Carea; a signal extraction module for extracting effective scanning signals of the T area and the C area; a signal homogenization reconstruction module for homogenizing and reconstructing the effective scanning signals of the T and C areas; and a concentration calculation module of a tested object for acquiring the concentration of the tested object according to the area of the scanning signals after reconstruction of the T and C areas. The above device is applied to a micro-fluidic biochip scanning type detection process, and can solve the problem of inconsistent lengths of extracted signalsin the T area and the C area of the induced fluorescence, non-uniform distribution of measured signals in the areas and the like.

Description

technical field [0001] The present disclosure relates to the technical field of immunodetection of microfluidic biochips, in particular to a microfluidic biochip scanning signal detection device. Background technique [0002] On-site point of care testing (POCT) is a detection method that can obtain results quickly after taking blood samples from patients on the spot, and other personnel who have not received professional clinical test training. It is of great significance to improve the diagnosis and treatment level of grass-roots hospitals and solve the dilemma of China's medical reform. POCT testing instruments have outstanding advantages such as simple and fast operation and instant results, and are one of the fastest-growing segments of the in vitro diagnostic industry in recent years. [0003] Microfluidic technology is one of the important ways to realize POCT. It uses microchannel structures with a scale of tens to hundreds of microns to process and manipulate micro...

Claims

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Application Information

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IPC IPC(8): G01N21/64B01L3/00
CPCB01L3/5027B01L2200/027B01L2200/10G01N21/6402G01N21/6428G01N21/6486
Inventor 李勇孔全存王志强钟昊佟浩徐涛索轶平
Owner TIANJIN RES INST FOR ADVANCED EQUIP TSINGHUA UNIV
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