Additive composition containing lysozyme and plant extract

A plant extract, lysozyme technology, applied in the directions of drug combination, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of inhibiting oral bacteria, not obvious bacteriostatic effect, affecting food quality, etc. Achieve good broad-spectrum bactericidal effect, make up for weak bacteriostatic efficacy, and make up for weak bactericidal ability

Inactive Publication Date: 2019-09-17
HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial efficacy of most plant extracts is relatively low, and the antibacterial effect is not obvious when used in small doses. When used in large doses, there ar

Method used

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  • Additive composition containing lysozyme and plant extract
  • Additive composition containing lysozyme and plant extract
  • Additive composition containing lysozyme and plant extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A product containing lysozyme and plant extracts (Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, tea leaf extract, Glycyrrhiza glabra root extract, Chamomile flower extract, Rosemary leaf extract One or more) compound, according to the evaluation method of QB 2738-2012 antibacterial and bacteriostatic effect of daily chemical products, determine the effect of additive composition or monomer raw material on the common pathogenic bacteria Streptococcus mutans (G - ), Porphyromonas gingivalis (G - ), Staphylococcus aureus (G + ), Escherichia coli (G - ) inhibition.

[0035] 1. To study the antibacterial effect of monomer raw materials, the formula is any one of formulas 1 to 11 in Table 1.

[0036] Table 1 Composition and antibacterial effect of formulas 1 to 11

[0037]

[0038]

[0039] As can be seen from the results in Table 1, the inhibitory effect of lysozyme on Gram-positive bacteria is better than that of...

Embodiment 2

[0055] According to the results of Example 1, the compound of lysozyme + seven kinds of plant extracts was applied in toothpaste.

[0056] A toothpaste containing an additive composition of lysozyme and plant extracts. For the specific formula of the toothpaste, see formulas 33-39 in Table 5.

[0057] The preparation process is as follows:

[0058] Add humectants (sorbitol, polyethylene glycol, propylene glycol, glycerin), abrasives (silicon dioxide, calcium carbonate, calcium hydrogen phosphate, aluminum hydroxide), binders (sodium carboxymethylcellulose, xanthan gum , carrageenan), water, foaming agent (sodium lauryl sulfate, sodium lauryl sarcosinate, cocamidopropyl betaine), sweetener (sodium saccharin, sucralose), keep the vacuum At -0.090Mpa~-0.096Mpa, stir for 20~50min; then add food flavor, lysozyme, plant extract (one or more of the seven kinds), keep the vacuum at -0.090Mpa~-0.096Mpa, stir 10 to 50 minutes to prepare a paste.

[0059] According to the evaluation m...

Embodiment 3

[0067] According to the results of Example 1, the compound of lysozyme + seven kinds of plant extracts was applied to the oral care solution.

[0068] An oral care solution containing an additive composition of lysozyme and plant extract. The specific formula of the oral care solution is shown in Table 6, formulas 40-46.

[0069] The preparation process is as follows:

[0070] Preparation of water-soluble components of group A: add humectants (polyethylene glycol, propylene glycol, glycerin), surfactants (sodium lauroyl sarcosinate, cocamidopropyl betaine), sweeteners (sodium saccharin , sucralose), water, stirring for 10-50min;

[0071] Preparation of group B oil-soluble components: Add solubilizer (PEG-40 hydrogenated castor oil, poloxamer 407), essence, ethanol, and stir for 10-50 minutes;

[0072] Component C is lysozyme and plant extract; add group A to group B and stir for 10-50 minutes; add components of component C to the AB mixture that has been fully mixed and stir...

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Abstract

The invention discloses an additive composition containing lysozyme and a plant extract. The additive composition consists of lysozyme and the plant extract. The plant extract is one or more of a centella asiatica extract, a giant knotweed rhizome extract, a scutellaria baicalensis root extract, a tea extract, a glycyrrhiza glabra root extract, a chamomilla recutita flower extract and a rosemary leaf extract. The lysozyme is used in combination with one or more of the plant extracts, so that on one hand, the problem is solved that oral care products which frequently use chemical components easily cause ecological imbalance of oral bacteria, make the bacteria generate drug resistance and cannot achieve the effect of preventing oral diseases; on the other hand, the defect of weak bactericidal ability of the lysozyme to gram-negative bacteria is overcome, meanwhile the defect of weak bacteriostatic effect of single plant extracts is overcome, and accordingly the additive composition containing the lysozyme and the plant extract has a good broad-spectrum bacteriostatic effect.

Description

technical field [0001] The invention relates to the technical field of lysozyme application, in particular to an additive composition containing lysozyme and plant extracts. Background technique [0002] Oral problems are mainly caused by bacteria. Using effective toothpaste, mouthwash and treatment of oral diseases can significantly reduce the number of pathogenic bacteria in the oral cavity, improve or even eliminate oral diseases. Oral care products such as toothpaste and oral care liquid can achieve these functions mainly by the active ingredients or antibacterial ingredients in the products. These antibacterial ingredients are mostly chemical antibacterial agents (such as triclosan, cetylpyridinium chloride, Chlorhexidine, antibiotics, etc.), frequent use of oral care products containing these ingredients can easily cause oral microecological imbalance, or cause bacteria to develop drug resistance, which cannot prevent oral diseases, but instead leads to other oral dise...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K8/9789A61K8/66A61Q11/00A61P31/04A61P7/04A61P1/02
CPCA61K8/66A61K36/23A61K36/287A61K36/484A61K36/53A61K36/539A61K36/704A61K36/82A61K38/47A61Q11/00A61K8/9789A61P1/02A61P7/04A61P31/04C12Y302/01017A61K2300/00
Inventor 褚夫江徐天生耿帅峰欧阳学琭
Owner HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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