Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cell microenvironment regulating chip device based on groove liquid drop capturing

A cell microenvironment and chip technology, applied in the field of microfluidic technology research, can solve problems such as large limitations and difficult and cumbersome operations

Inactive Publication Date: 2019-09-20
BEIJING UNIV OF TECH
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the internal microenvironment of the droplet for cell survival and operation is mostly based on simple microchannels and double-branch capture microchannels, but these two methods are difficult to operate and have great limitations.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cell microenvironment regulating chip device based on groove liquid drop capturing
  • Cell microenvironment regulating chip device based on groove liquid drop capturing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The working process and effect of the invention will be further described below in conjunction with the structural drawings.

[0019] figure 1 It is a schematic diagram of the structure of a cell microenvironment regulation chip device based on groove droplet capture.

[0020] A cell microenvironment regulation chip device based on groove droplet capture. The channel includes a main body solid structure 1, an inlet 2, a 1:1 groove capture structure 3, a 1:2 groove capture structure 4, a 1:3 groove capture structure 5, a main channel structure 6, a groove necking structure 7, Outlet 8 and lower bottom plate 9. Inlet 2, 1:1 groove capture structure 3, 1:2 groove capture structure 4, 1:3 groove capture structure 5, main channel structure 6, groove neck structure 7, and outlet 8 are the main solid structure 1 The upper groove or hole structure, and each structure is the fluid flow area when the chip is working; the width range of the 1:1 groove capture structure 3 is set...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a cell microenvironment regulating chip device based on groove liquid drop capturing and belongs to the technical field of microfluidics. The device comprises a main solid structure, inlets, groove capturing structures of different transverse-longitudinal ratios, a main channel structure, an outlet and a lower bottom plate and can regulate cell microenvironments. The device has the advantages that the requirements of different experiment conditions are satisfied by the different transverse-longitudinal ratios, experiment costs are saved, and experiments are facilitated; the necking-down design of the groove inlets can change shear stress in the grooves, and the regulation of the living environments of different kinds of cells is benefited; the defect that a traditional device is complex and difficult to operate, and the device is simple in structure and capable of increasing experiment precision and increasing experiment scheme flexibility; the device can facilitate high-precision cell microenvironment regulation and is of great significance to the scientific researches of biological medicine.

Description

technical field [0001] The invention relates to a novel experimental device which can be used for the regulation experiment of cell microenvironment. The invention belongs to the research field of microfluidic technology. Background technique [0002] As an important branch of microfluidic chip research, droplet microfluidics has been developed on the basis of traditional continuous flow microfluidics systems in recent years. It can be simulated in biological cells through the generation, merging and fusion of droplets. The chemical reactions carried out play an important role in many fields such as medical diagnosis, drug development, biological cell analysis, and biological cell synthesis. Droplet microfluidics has been applied to flow cytometry due to its advantages of easy manipulation, high throughput and avoidance of cross-contamination. The study of the microenvironment inside the droplet is the basis for the regulation of the microenvironment of sperm cells. The in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12M1/00
CPCC12M23/16
Inventor 申峰闫成金刘赵淼李梦麒
Owner BEIJING UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com