Cell microenvironment regulating chip device based on groove liquid drop capturing

A cell microenvironment and chip technology, applied in the field of microfluidic technology research, can solve problems such as large limitations and difficult and cumbersome operations

Inactive Publication Date: 2019-09-20
BEIJING UNIV OF TECH
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  • Abstract
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Problems solved by technology

At present, the research on the internal microenvironment of the droplet for cell survival and operation is mostly based on simple

Method used

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  • Cell microenvironment regulating chip device based on groove liquid drop capturing
  • Cell microenvironment regulating chip device based on groove liquid drop capturing

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Experimental program
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Embodiment Construction

[0018] The working process and effect of the invention will be further described below in conjunction with the structural drawings.

[0019] figure 1 It is a schematic diagram of the structure of a cell microenvironment regulation chip device based on groove droplet capture.

[0020] A cell microenvironment regulation chip device based on groove droplet capture. The channel includes a main body solid structure 1, an inlet 2, a 1:1 groove capture structure 3, a 1:2 groove capture structure 4, a 1:3 groove capture structure 5, a main channel structure 6, a groove necking structure 7, Outlet 8 and lower bottom plate 9. Inlet 2, 1:1 groove capture structure 3, 1:2 groove capture structure 4, 1:3 groove capture structure 5, main channel structure 6, groove neck structure 7, and outlet 8 are the main solid structure 1 The upper groove or hole structure, and each structure is the fluid flow area when the chip is working; the width range of the 1:1 groove capture structure 3 is set...

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Abstract

The invention relates to a cell microenvironment regulating chip device based on groove liquid drop capturing and belongs to the technical field of microfluidics. The device comprises a main solid structure, inlets, groove capturing structures of different transverse-longitudinal ratios, a main channel structure, an outlet and a lower bottom plate and can regulate cell microenvironments. The device has the advantages that the requirements of different experiment conditions are satisfied by the different transverse-longitudinal ratios, experiment costs are saved, and experiments are facilitated; the necking-down design of the groove inlets can change shear stress in the grooves, and the regulation of the living environments of different kinds of cells is benefited; the defect that a traditional device is complex and difficult to operate, and the device is simple in structure and capable of increasing experiment precision and increasing experiment scheme flexibility; the device can facilitate high-precision cell microenvironment regulation and is of great significance to the scientific researches of biological medicine.

Description

technical field [0001] The invention relates to a novel experimental device which can be used for the regulation experiment of cell microenvironment. The invention belongs to the research field of microfluidic technology. Background technique [0002] As an important branch of microfluidic chip research, droplet microfluidics has been developed on the basis of traditional continuous flow microfluidics systems in recent years. It can be simulated in biological cells through the generation, merging and fusion of droplets. The chemical reactions carried out play an important role in many fields such as medical diagnosis, drug development, biological cell analysis, and biological cell synthesis. Droplet microfluidics has been applied to flow cytometry due to its advantages of easy manipulation, high throughput and avoidance of cross-contamination. The study of the microenvironment inside the droplet is the basis for the regulation of the microenvironment of sperm cells. The in...

Claims

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Application Information

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IPC IPC(8): C12M1/00
CPCC12M23/16
Inventor 申峰闫成金刘赵淼李梦麒
Owner BEIJING UNIV OF TECH
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