Croton crassifolius root extract prepared through supercritical fluid extraction as well as method and application thereof

An extraction method and supercritical fluid technology, which are applied in the fields of drug combination, bulk chemical production, organic chemistry, etc., can solve the problems of less research, and achieve the effect of high anti-tumor activity, easy industrialization and high purity

Active Publication Date: 2019-10-01
INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, it is reported that the low polar part of the herb is rich in active compounds, but there...

Method used

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  • Croton crassifolius root extract prepared through supercritical fluid extraction as well as method and application thereof
  • Croton crassifolius root extract prepared through supercritical fluid extraction as well as method and application thereof
  • Croton crassifolius root extract prepared through supercritical fluid extraction as well as method and application thereof

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Embodiment 1

[0030] (1) Materials and methods

[0031] Crassifolius roots were purchased at a Chinese herbal medicine market in Bozhou, Anhui, China, in October 2017. This species was identified by Prof. Shan Chenggang, Institute of Agricultural Products, Shandong Academy of Agricultural Sciences (IAST, SAAS), Jinan, China. Voucher samples (No.17-10-29) are kept at the IAST Bioactive Substances and Functional Foods Laboratory at SAAS.

[0032] (2) Extraction process:

[0033] Take the dried root of Jiguxiang, pulverize it with a traditional Chinese medicine grinder, and pass through a 40-mesh sieve (450 μm). Weigh 2.0 kg of sample and fill it with supercritical CO in 10 times 2 In the reaction vessel (650 mL) of the fluid extractor, 200 g each time. At 25 MPa, 35 o C under static extraction for 30 minutes, followed by dynamic extraction for 30 minutes (CO 2 Flow rate 5.0 L / min), with methanol as entrainer (flow rate 5.4 mL / min). A total of 100.4 g of dark yellow extract was obtain...

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Abstract

The invention belongs to the technical field of medicine extraction and particularly relates to a croton crassifolius root extract prepared through supercritical fluid extraction as well as a method and application thereof. The croton crassifolius root extract is named as a compound J-1 and the specific structural formula is (as shown in the description). According to the compound medicine extracted by the method, raw materials are easily available, industrialization is facilitated, different dosage forms can be prepared according to requirements and huge social benefit is achieved. The extracted compound has high purity and high anti-tumor activity, has the effects of resisting proliferation and inducing cell apoptosis and has potential serving as a candidate of an anti-cancer therapy method.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a super-proximity fluid extraction of chicken bone vetch root extract and a method and application thereof. Background technique [0002] The genus Croton belongs to the family Euphorbiaceae, with more than 1300 species in the world, and is a large genus widely distributed in tropical and subtropical regions. About 21 species of Croton grow in China, some of which have long been used to relieve dysmenorrhea and Chinese medicine for indigestion and malaria. Plants of the Croton genus are known for their variety of terpenoids with a wide range of biological activities. In addition, alkaloids, flavanones, lignans, polyphenolic compounds, phenylbutyric acid and peptides were obtained. [0003] Croton crassifolius Geisel is a species of Croton, mainly distributed in southern China and other parts of Southeast Asia. As a Chinese medicinal herb called "Ji Gu X...

Claims

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Application Information

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IPC IPC(8): C07D493/10A61P35/00
CPCA61P35/00C07D493/10Y02P20/54
Inventor 刘超孙金月张瑞瑞王青程安玮王新坤郭溆
Owner INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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