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Traditional Chinese medicine preparation with tuberous roots of stephania sinica Diels and preparation method of preparation

A technology of traditional Chinese medicine preparations, gold does not change, applied in the direction of medical formulas, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of difficulty in the preparation of dispersible tablets, many impurities, etc., and achieve the goal of improving bioavailability and improving curative effect Effect

Active Publication Date: 2019-10-18
广西万寿堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the original preparation process of Jinlian Weishu Tablets, the medicinal flavor of the old snake lotus in the other party was not extracted, and it was directly crushed and used as medicine. There were many impurities, so it was difficult to apply to the preparation of dispersible tablets.

Method used

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  • Traditional Chinese medicine preparation with tuberous roots of stephania sinica Diels and preparation method of preparation
  • Traditional Chinese medicine preparation with tuberous roots of stephania sinica Diels and preparation method of preparation
  • Traditional Chinese medicine preparation with tuberous roots of stephania sinica Diels and preparation method of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] R1. Take 75g of Jinbuchang root, cleanly select, dry, crush into coarse powder, add dilute hydrochloric acid to moisten, soak for 2 hours, add 10 times the amount of ethanol to reflux for extraction twice, each time for 2 hours, filter, combine the filtrate, and concentrate the filtrate to thick Ointment, dried, pulverized, passed through 100 meshes, and the total alkaloids can be obtained without changing gold;

[0042] R2. Get 147 parts of alum (calcined), 4 parts of Jinbuhuan total alkali, and 143 parts of old snake lotus;

[0043] R3. Take the old snake lotus, crush it into a coarse powder, add 50% ethanol solution for reflux extraction 3 times, add 15 times the amount for reflux extraction for 2 hours for the first time, add 12 times the amount for reflux extraction for 1 hour for the second time, and add 8 times for the third time Extract under reflux for 1 hour, combine the extracts, filter, recover ethanol from the filtrate and concentrate to a thick paste, dry ...

Embodiment 2

[0051] R1. Take 75g of Jinbuchang root, cleanly select, dry, crush into coarse powder, add dilute hydrochloric acid to moisten, soak for 2 hours, add 10 times the amount of ethanol to reflux for extraction twice, each time for 2 hours, filter, combine the filtrate, and concentrate the filtrate to thick Ointment, dried, pulverized, passed through 100 meshes, and the total alkaloids can be obtained without changing gold;

[0052] R2. Get 147 parts of alum (calcined), 4 parts of Jinbuhuan total alkali, and 143 parts of old snake lotus;

[0053] R3. Take the old snake lotus, crush it into a coarse powder, add 50% ethanol solution for reflux extraction twice, add 13 times the amount for reflux extraction for 2 hours for the first time, add 9 times the amount for reflux extraction for 1 hour for the second time, combine the extracts, filter, The ethanol is recovered from the filtrate and concentrated to a thick paste, dried to obtain a dry paste, pulverized, and passed through 100 m...

Embodiment 3

[0061]R1. Take 75g of Jinbuchang root, cleanly select, dry, crush into coarse powder, add dilute hydrochloric acid to moisten, soak for 2 hours, add 10 times the amount of ethanol to reflux for extraction twice, each time for 2 hours, filter, combine the filtrate, and concentrate the filtrate to thick Ointment, dried, pulverized, passed through 100 meshes, and the total alkaloids can be obtained without changing gold;

[0062] R2. Get 147 parts of alum (calcined), 4 parts of Jinbuhuan total alkali, and 143 parts of old snake lotus;

[0063] R3. Take the old snake lotus, crush it into a coarse powder, add 10 times the amount of 50% ethanol solution to reflux and extract twice, each time for 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate and concentrate to a thick paste, dry to obtain a dry paste , pulverized, and passed through 100 meshes to obtain dry cream powder;

[0064] R4. get alum (calcined), pulverize, cross 100 mesh, get alum fine powde...

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Abstract

The invention discloses a traditional Chinese medicine preparation with tuberous roots of stephania sinica Diels and a preparation method of the preparation. The preparation is mainly prepared from, by weight, 147 parts of alumen (calcined), 4 parts of total alkali of the tuberous roots of stephania sinica Diels and 143 parts of rhizomes of tupistra chinensis Bak.. According to the preparation method, medicinal materials including the rhizomes of tupistra chinensis Bak. and the tuberous roots of stephania sinica Diels are subjected to alcohol extraction and made into dispersible tablets, the bioavailability of the product is improved, and the defects are overcome that for common tablets and capsules, slow disintegration occurs, the effect is slowly achieved, and the dissolution rate and bioavailability are low. The treatment effect of the product is improved.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a traditional Chinese medicine preparation containing gold and a preparation method thereof. Background technique [0002] Dispersible tablets, also known as water dispersible tablets, refer to tablets that can be rapidly disintegrated in contact with water to form a uniform viscous suspension. Compared with ordinary tablets, dispersible tablets absorb quickly, have high bioavailability, have less adverse reactions, and can reduce the irritation of the drug to the gastrointestinal tract. Dispersible tablets are easy to take, can be swallowed, chewed, sucked, or can be dispersed in water and taken alone or with fruit juice or milk, especially suitable for the elderly, young and patients who have difficulty swallowing solids. [0003] Jinlian Weishu tablet is recorded in WS-10762(ZD-0762)-2002. It is prepared from alum, total alkaloids of Jinbuhuan and three traditional Chinese medicines ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/20A61P1/04A61P1/00A61P1/14A61K33/06
CPCA61K33/06A61K36/59A61K36/896A61K9/2009A61P1/04A61P1/00A61P1/14A61K2300/00Y02A50/30
Inventor 李修善韦德何雪玲
Owner 广西万寿堂药业有限公司
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