Prenylated flavonoid compounds, and preparation method and applications thereof

A technology of prenylated flavonoids and compounds, applied in the field of medicine, to achieve the effects of preparation method operation, rich raw materials, and significant economic and social benefits

Active Publication Date: 2019-11-01
HENAN UNIV OF CHINESE MEDICINE
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a kind of prenylated flavonoids and its preparation method and application, which can effectively solve the problem of preparation and preparation of prenylated flavonoids. The problem with active drugs against breast cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Prenylated flavonoid compounds, and preparation method and applications thereof
  • Prenylated flavonoid compounds, and preparation method and applications thereof
  • Prenylated flavonoid compounds, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]The preparation method of a kind of prenylated flavonoids of the present invention is, take 9 kg of the lotus lobata medicinal material as raw material, use 18 L, the volume concentration is 95% ethanol heating reflux extraction 3 times, extraction temperature is 95 ℃, each extraction time For 1.5 hours, ethanol was recovered under reduced pressure to obtain extract-like ethanol extract, which was suspended in 3.2L of distilled water, and extracted 3 times with petroleum ether, dichloromethane, ethyl acetate, and n-butanol successively, each time at 3.2 L, the time is 1.5 hours; the ethyl acetate extraction part is preliminarily separated by silica gel column chromatography, and the volume ratio is 100:0, 100:5, 100:7, 100:10, 100:30, 100:50, 100 :70, 100:100, 100:200, and 0:100 petroleum ether-acetone mixed solvent systems for gradient elution, each gradient uses 13L eluent, the flow rate is 15mL / min, and each 500ml volume is a fraction, collected 260 fractions, each fr...

Embodiment 2

[0034] The preparation method of a kind of prenylated flavonoids of the present invention is, take 6 kg of the phyllophyllum medicinal material as raw material, use 30 L, the volume concentration is 75% ethanol heating reflux extraction 3 times, extraction temperature is 90 ℃, each extraction time For 2 hours, ethanol was recovered under reduced pressure to obtain extract-like ethanol extract, which was suspended in 2L of distilled water, and extracted three times with petroleum ether, dichloromethane, ethyl acetate, and n-butanol in sequence, 2L each time, The time is 2 hours; the ethyl acetate extraction part is preliminarily separated by silica gel column chromatography, and the volume ratio is 100:0, 100:5, 100:7, 100:10, 100:30, 100:50, 100:70 , 100:100, 100:200, 0:100 petroleum ether-acetone mixed solvent system for gradient elution, each gradient uses 9.1L eluent, the flow rate is 10mL / min, every 350ml volume is a fraction, and 260 Each flow fraction and each fraction a...

Embodiment 3

[0036]The preparation method of a kind of prenylated flavonoid compound of the present invention is, take 8 kg of the phyllophyllum medicinal material as raw material, with 24L, the volume concentration is 85% ethanol heating reflux extraction 3 times, extraction temperature is 92 ℃, each extraction time For 1.5 hours, ethanol was recovered under reduced pressure to obtain extract-like ethanol extract, which was suspended in 2.8L of distilled water, and extracted three times with petroleum ether, dichloromethane, ethyl acetate, and n-butanol in sequence, 2.8L each time , the time was 1.5 hours; the ethyl acetate extraction part was preliminarily separated through silica gel column chromatography, and the volume ratio was 100:0, 100:5, 100:7, 100:10, 100:30, 100:50, 100: 70, 100:100, 100:200, 0:100 petroleum ether-acetone mixed solvent system for gradient elution, each gradient uses 11.7L eluent, flow rate is 13mL / min, every 450ml volume is a fraction, collect 260 fractions, ea...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to prenylated flavonoid compounds, and a preparation method and applications thereof. The preparation method is capable of solving prenylated flavonoid compounds preparation andbreast cancer prevention drug preparation problems. The prenylated flavonoid compounds are sinoflavonoid P, sinoflavonoid NB, sinoflavonoid NC, sinoflavonoid ND, and sinoflavonoid NE extracted from Sinopodo-phullum hexandrum. The prenylated flavonoid compounds can be used for preparation of breast cancer prevention drugs; the raw material is abundant; operation method is convenient; practical clinical value is achieved; and economical and social benefit is excellent.

Description

technical field [0001] The invention relates to medicine, in particular to a prenylated flavonoid compound with anti-breast cancer activity and its preparation method and application. Background technique [0002] Malignant tumor is a common and frequently-occurring disease that seriously threatens human health and life. Today, cancer is the leading cause of death worldwide. Breast cancer is a malignant tumor that usually occurs in the glandular epithelial tissue of the breast. It has become one of the major diseases that seriously threaten the health and life of young and middle-aged women. The number of newly diagnosed breast cancer is more than 1 million. Although there are many drugs for the treatment of breast cancer at present, all of them have strong toxic and side effects. Among them, the reduction of digestive function and the inhibition of bone marrow hematopoietic function are the most obvious. It often makes it difficult for breast cancer patients to persist in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D311/30C07D311/40C07D493/04A61P35/00
CPCA61P35/00C07D311/30C07D311/40C07D493/04
Inventor 孙彦君王俊敏冯卫生陈辉郝志友张艳丽高美玲陈豪杰赵晨韩瑞杰
Owner HENAN UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap