Krebs-type polyacid compound and preparation method thereof

A multi-acid compound and chemical formula technology, applied in the field of anti-tumor drugs, can solve the problems of high toxicity, tumor cell drug resistance, poor selectivity, etc., and achieve the effect of low toxicity, strong cell penetration ability, and strong anti-tumor activity

Pending Publication Date: 2019-11-08
YANGZHOU UNIV
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  • Abstract
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Problems solved by technology

However, the above-mentioned polyacid antitumor chemical drugs still have disadvantages such as low efficiency, poor selectivity, large toxic and side effects, and drug resistance of tumor cells.

Method used

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  • Krebs-type polyacid compound and preparation method thereof
  • Krebs-type polyacid compound and preparation method thereof
  • Krebs-type polyacid compound and preparation method thereof

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preparation example Construction

[0035] The {SbW adopted in the following examples 9} preparation reference [M. I. Loose, H. Pohlmann,

[0036] B. Krebs. Chem. Eur. J. 8 (1997) 1232-1233].

Embodiment 1

[0039] Weigh 110mg{SbW 9} was dissolved in 30mL of distilled water, stirred to dissolve, and then 90mg of Mn(CH 3 COO) 2 4H 2 O, after stirring and dissolving, add 35 mg of 1,2,4-triazole. After all the substances are dissolved, adjust the pH of the solution to 3.0 with acetic acid, and the color of the solution changes from orange to light yellow. Naturally volatilize at room temperature for 15 to 20 days, and crystallize to obtain a yellow block single crystal, that is, the Krebs type polyacid compound Na 2 mn 2 h 6 [Mn 2 (H 2 O) 2 (trz) 2 (SbO 2 ) 2 (SbW 9 o 33 ) 2 ](POM-Mn), its structure see Figure 9 . The yield was 43.25%, based on {SbW 9}.

Embodiment 2

[0041] Weigh 110mg{SbW 9} was dissolved in 30mL of distilled water, stirred to dissolve, and then 90mg of Mn(CH 3 COO) 2 4H 2 O Stir to dissolve and add 35 mg of 1,2,4-triazole. After all the substances are dissolved, adjust the pH of the solution to 2.0 with acetic acid, and the color of the solution changes from orange to light yellow. Naturally volatilize at room temperature for 15 to 20 days, and crystallize to obtain a yellow block single crystal, that is, the Krebs type polyacid compound Na 2 mn 2 h 6 [Mn 2 (H 2 O) 2 (trz) 2 (SbO 2 ) 2 (SbW 9 o 33 ) 2 ] (POM-Mn).

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Abstract

The invention discloses a Krebs-type polyacid compound and a preparation method thereof. Based on a unit {SbW9}, the Krebs-type polyacid compound Na2Mn2H6[Mn2(H2O)2(trz)2(SbO2)2(SbW9O33)2] is synthesized by self-assembly of 1,2,4-triazole and transition metal, and during the reaction, Sb(III) is partially oxidized to Sb(V). According to the invention, the structural characteristics of polyoxometallate and the biological effect of anti-tumor activity are utilized, and organic groups are introduced into a polyoxometallate (POM) framework to change the surface charge, polarity and oxidation-reduction characteristics of the POM framework, so that the functional POM with lower toxicity and higher cell penetration capacity is formed, and the prepared Krebs-type polyacid compound has an inhibition effect on tumor cells, shows high anti-tumor activity on gastric cancer cells, and can be used as an anti-tumor medicine.

Description

technical field [0001] The invention belongs to the technical field of antitumor drugs, and relates to a Krebs type polyacid compound and a preparation method thereof. Background technique [0002] Cancer is one of the diseases that threaten human health at present. Chemotherapy has become an important means of tumor treatment. Finding high-efficiency, low-toxic antitumor drugs has become the focus of current chemotherapy research. In the 1990s, many studies have reported that polyoxometalates (POMs) have antiviral, antibacterial, and antitumor effects. Among them, high-nuclear transition metal-substituted polyacids have been widely studied in biological activity. Among these polyacids, sandwich polyoxyanions are an important research branch. Wang et al. synthesized organotin-substituted polyacids K 4 h 3 [(CH 3 CO 2 CH 2 CH 2 Sn) 3 (α-GeW 9 o 37 )]10H 2 O isomer, and has antitumor activity [X.H.Wang, J.F.Liu, R.Zhang, Main Group Met.Chem.25, (2002) 535-539]. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F13/00A61P35/00
CPCA61P35/00C07F13/005
Inventor 倪鲁彬陈鹏赵红霞刁国旺张颖徐红杰
Owner YANGZHOU UNIV
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