40results about How to "Change surface charge" patented technology

The invention relates to a polymer lipid nanoparticle, a preparation method and application thereof as a vaccine adjuvant system. The polymer nanoparticle is a solid sphere composed of a macromoleclar polymer, positively charged cationic lipid is inlaid on the surface, the nanoparticle surface can adsorb protein antigen, polypeptide antigen, viral antigen and other active drugs; the polymer nanoparticle has an average particle size of less than 300nm, a dispersion coefficient, i.e. a PDI (polydispersity) value of less than 0.2, and a Zeta potential average value of greater than 20mV. The polymer nanoparticle provided by the invention has the characteristics of uniform size, high antigen carrying rate, and good maintenance of antigen activity, when the polymer nanoparticle carries an antigen and serves as a vaccine adjuvant, the intake of antigen presenting cells (APCs) to the antigen can be increased, the activation level of antigen presenting cells is improved, and the follow-up immune response level is strengthened.

The invention discloses a method for preparing a nano FeOx / NiOy / mesoporous material catalyst. The method comprises the following steps: mixing and soaking an aqueous solution of Ni<2+> and Fe<3+> with a mesoporous material, drying, roasting and reducing to prepare a mixed-phase multi-metal oxide catalyst. The invention further discloses a catalyst prepared by the method and an application of the catalyst. According to the method disclosed by the invention, the mesoporous material is utilized to perform spatial definition on the growth of nano particles to obtain the nano particles with uniform particle diameters. Iron and nickel are co-loaded to further improve the shapes, the particle diameters and the dispersion of the nano particles, so that the activity of the catalyst is greatly improved, and the Fenton degradation rate and the hydrogen peroxide utilization rate of the organic substances are greatly increased. The catalyst application method is simple, the types and the proportions of the active ingredients can be precisely controlled through the reducing temperature, and multiple components co-exist in a polyvalent manner. The preparation method disclosed by the invention is simple; and the oxidant is green and environment-friendly, high in utilization rate, can directly react at a room temperature and has an industrial application prospect.

The invention provides a compound type sludge dewatering conditioner which comprises the following components in parts by weight: 3-6 parts of ferric trichloride, 3-6 parts of calcium oxide, 1-2 parts of magnesium oxide, 1-4 parts of surfactant and 1-2 parts of sulfuric acid. The compound type sludge dewatering conditioner provided by the invention can realize efficient dewatering of sludge, the conditioning technology is simple and quick, the dosage of the conditioner is small, the moisture content of the dewatered sludge is reduced to below 45%, the pH value is 6-7, foul smell and the problem of capacity increase are avoided, and sludge reduction can be realized; and the compound type sludge dewatering conditioner has good environmental benefits, is favorable for subsequent sludge resource utilization, can be widely applied to the sewage and sludge treatment of the industries such as chemical industry, municipal affairs and the like, and is particularly suitable for treating the domestic sludge of urban sewage plant.

The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation for solubilizing insoluble compound resveratrol based on synergistic supersaturation and a preparation method thereof. The preparation includes: resveratrol, water-soluble polymer material as crystallization inhibitor, cyclodextrin as encapsulation agent, phospholipid and sodium cholate as surfactant, and the preparation includes the following components in weight ratio : Resveratrol 10-25 parts, water-soluble polymer material 65-83 parts, cyclodextrin 6-21 parts, phospholipid 0.6-3 parts, sodium cholate 0.4-1 part.

The invention discloses a compounded sludge dewatering conditioner and application and a method thereof. The compounded sludge dewatering conditioner comprises the following components in parts by weight: 2-6 parts of ferric trichloride, 2-6 parts of magnesium chloride, 2-6 parts of calcium oxide, 1-3 parts of magnesium oxide, 1-3 parts of calcium aluminate, 2-4 parts of sodium dodecyl benzene sulfonate, 0.5-1 part of sulfuric acid and 0.5-1 part of ammonium chloride. After the sludge is dewatered by the compounded sludge dewatering conditioner, the moisture content of the sludge is reduced to be less than 45%, and the pH of the sludge is between 6-7; the sludge does not stink; less usage amount of the conditioner does not cause the problem of capacity increasing, and sludge reduction can be realized, so that the environmental benefit is good, the conditioner is beneficial to sludge resource utilization in following step, can be widely applied to sewage and sludge treatment in chemical industry, municipal administration and the like, and is very suitable for domestic sludge treatment in town sewage plants.

The invention belongs to the technical field of inorganic nano materials and molecular imaging and in particular relates to a multifunctional nanocomposite as well as a preparation method and application thereof. The preparation method comprises the following steps: adding SH-PEG-NH2 into a gold nanocage wrapped by PVP on the surface, stirring for 8-20 hours, centrifuging, and washing, so that the gold nanocage wrapped by SH-PEG-NH2 on the surface is obtained; adding PVP into iridium 2-phenylquinoline-3,3'-bipyridine dicarboxylic acid solution, heating to 100-120 DEG C, and maintaining for 10-40 minutes; quickly dropwise adding dysprosium acetate solution, and reacting, so that reaction liquid is obtained; mixing the gold nanocage wrapped by SH-PEG-NH2 with the reaction liquid, carrying out dialysis reaction, centrifuging, and washing. The multifunctional nanocomposite provided by the invention can serve as a photoacoustic imaging / optical imaging / magnetic resonance imaging contrast agent and also has the function of carrying out photothermal therapy and photodynamic therapy, so that the multifunctional nanocomposite provided by the invention is a nano material which realizes integration of tumour diagnosis and treatment.

An abrasion-resisting lining plate for producing aluminum oxide in ore grinding operation comprises a steel lining plate and an abrasion-resisting rubber lining plate arranged on the inner wall face of the steel lining plate. A plurality of counter bores are distributed in the inner wall face of the steel lining plate so that when abrasion-resisting rubber materials is pressed into the abrasion-resisting rubber lining plate on the inner wall face of the abrasion-resisting rubber lining plate, part of abrasion-resisting rubber materials enter the counter bores to form connection bolt columns toachieve connection between the steel lining plate and the abrasion-resisting rubber lining plate. According to the abrasion-resisting lining plate, due to the fact that the abrasion-resisting rubberlining plate is arranged on the surface of the steel lining plate, the abrasion-resisting rubber lining plate plays a role in protecting the steel lining plate when a grinding body and ores directly impact the abrasion-resisting rubber lining plate, the abrasion-resisting rubber lining plate is easy to change after being damaged, and the service life of the steel lining plate is greatly prolonged.

The present invention relates to the technical field of vitamin K2, in particular to a preparation method of vitamin K2, which comprises the following steps: (1) adding a composite flocculant to the fermentation liquid of Bacillus natto, then performing solid-liquid separation, and collecting the liquid as the liquid, spare. (2) Concentrating the liquid to be extracted into a concentrate for subsequent use. (3) Freeze-drying the concentrated solution to obtain a freeze-dried powder containing crude vitamin K2 for future use. (4) Dissolving the freeze-dried powder in acetone, after the freeze-dried powder is completely dissolved, add water as a precipitant to precipitate vitamin K2, separate the precipitate and remove the acetone in the remaining liquid and reclaim it, and the remaining liquid is the mother liquor ,spare. (5) The mother liquor is combined with the concentrate prepared in the next step (3) to realize recycling of the mother liquor. The method of the present invention can not only effectively improve the purification degree of vitamin K2, but also can realize the effective utilization of mother liquor after extracting vitamin K2.

The invention relates to the field of animal fur processing and particularly relates to an oxidation dyeing method utilizing potassium permanganate as a medium. The oxidation dyeing method comprises the following steps: preprocessing raw material fur, and carrying out wool opening by virtue of a first mixing water solution containing sodium carbonate, ammonia water and a degreasing agent; washing; soaking the washed raw material fur for 20-40 minutes by virtue of a water solution containing potassium permanganate and a penetrating agent, adding lactic acid, continuously soaking, and carrying out oxidation dyeing after the soaking; washing the dyed raw material fur for eliminating a flooding phenomenon, carrying out retanning, drying, adding oil, standing, dry washing, and dry shoveling, so as to obtain finished products. According to the oxidation dyeing method, the potassium permanganate is utilized for replacing toxic potassium dichromate to serve as a medium auxiliary during the oxidation dyeing, the thicknesses and pores of obtained oxidation films are uniform, and the colors of the dyed fur are uniform; furthermore, the process is safe and reliable to operate, the environmental pollution is effectively reduced, and the obtained fur is safe and harmless to human bodies.