13results about How to "Accelerates the infiltration process" patented technology

The invention relates to the field of paint spraying, in particular to a curved surface paint spraying boundary technology which comprises the following steps that S1, a first color layer is sprayed to a curved surface structure; s2, removing the first color layer on the second side of the color block boundary; s3, spraying a release interlayer on the curved surface structure, wherein the release interlayer is sprayed on the second side of the color block boundary and the surface of the first color layer; s4, removing the release interlayer on the second side of the color block boundary; s5, spraying a second color layer on the curved surface structure, wherein the second color layer is sprayed on the second side of the color block boundary and the surface of the release interlayer; and S6, removing the release interlayer so as to remove the second color layer sprayed on the surface of the release interlayer, and respectively forming a first color block and a second color block on the first side and the second side of the color block boundary. The multi-color paint spraying device has the effect of conveniently carrying out boundary multi-color paint spraying on the curved surface structure.

The invention provides a wood-plastic composite material prepared by using recycled polypropylene and orange peel and a preparation method thereof, and relates to the technical field of composite materials. The raw materials of the wood-plastic composite material include recycled polypropylene, orange peel powder, orange tree trunk wood pulp, maleic anhydride grafted polypropylene, a coupling agent, and an antioxidant. The invention uses recycled polypropylene and natural renewable materials to prepare the wood-plastic composite material, realizes the resource utilization of waste and the protection of the environment, and the prepared wood-plastic composite material has excellent mechanical properties and biodegradability.

The invention discloses an application of EGCG (epigallocatechin gallate) in preparation of a medicine for causing tumor immunogen cell death. The invention discovers that the micromolecule EGCG causes immunogenic death of colon cancer cells for the first time; eGCG is combined with an immune checkpoint inhibitor in vivo for treatment, so that the obvious inhibition effect on occurrence and development of colon cancer is achieved; meanwhile, EGCG can induce death of immunogenic cells of colon cancer cells, so that the colon cancer whole-cell vaccine is prepared, and after mice are immunized with the colon cancer whole-cell vaccine, the survival rate of the colon cancer tumor-bearing mice can be effectively increased. EGCG improves the effect function of CD8T cells by increasing the maturation and infiltration of DC cells, enhances the anti-tumor curative effect of an immune checkpoint inhibitor, and provides a new method and a new thought for tumor treatment.

The invention belongs to the field of biological medicine, and discloses a novel target of ID1 protein in tumor-associated macrophages (TAM) as an anti-tumor therapeutic drug and application of the novel target. The invention discloses that the expression of ID1 in TAM is obviously higher than that of para-carcinoma tissue macrophages for the first time, and the ID1 has a tumor promoting effect. Specifically, ID1 highly expressed in TAM can enhance the dryness of tumor cells and promote tumor growth and metastasis by obstructing CD8 + T cell recruitment in tumors. The tumor promoting phenotype of the TAM can be inhibited by reducing the expression of ID1 in the TAM through gene editing. The sensitivity of tumor cells including colon cancer, liver cancer and pancreatic cancer to chemotherapeutic drugs and immune checkpoint inhibitors can be improved by reducing the expression of ID1 in TAM by using a small molecule compound. The invention discloses a new tumor regulation and control promoting signal in a tumor immune microenvironment TAM, and the ID1 protein in the provided TAM can be used as a new tumor treatment target for anti-tumor drug screening. The method lays a theoretical foundation for an anti-tumor research and development strategy, and has a huge potential conversion application prospect.

The utility model provides a high-bulk embossing device which comprises at least one humidifying unit, at least one embossing unit, at least one embossing unit, at least one embossing unit and at least one embossing unit, wherein the at least one humidifying unit is used for humidifying a raw paper web to form a wet paper web; the knurling roller group is arranged at the downstream of the humidifying unit and is used for knurling the wet paper web to form a wet knurled paper web; the drying unit is arranged at the downstream of the embossing roller set and used for drying the embossed paper web to form a dry embossed paper web; wherein the humidifying unit comprises a transfer belt wound on a plurality of carrier rollers and a spray head used for spraying water to the transfer belt, the transfer belt comprises an abutting section abutting against a raw paper web, and the abutting section is configured to humidify the raw paper web making contact with the abutting section. And meanwhile, water can be distributed more uniformly in the mode, so that the accuracy of the addition amount is ensured, the unexpected paper breaking phenomenon is not easy to occur, the production speed is improved, and the bulk of paper can be further improved in the mode.

The invention belongs to the field of medicines, and discloses a composition for treating and / or preventing tumors and application thereof. The composition comprises any one of the following pharmaceutical compositions: (1) an ID1 inhibitor and a chemotherapeutic drug; and (2) an ID1 inhibitor and an immune checkpoint inhibitor drug. The chemotherapeutic drug is prepared from 5-fluorouracil, oxaliplatin, capecitabine or irinotecan. The immune checkpoint inhibitor drug is selected from a targeted CTLA-4 antagonistic antibody. The composition disclosed by the invention is an anti-tumor pharmaceutical composition for inhibiting ID1 activity, and experimental verification finds that the composition can improve the chemotherapy treatment effect or immunotherapy effect of tumor patients, so that a theoretical basis is laid for formulating a clinical anti-tumor treatment strategy, and the composition has a wide application prospect.

According to the double-expression protein particle provided by the invention, a target fragment of the double-expression protein particle comprises TNFSF14 and / or anti-CD3 svFc, and the target fragment of the double-expression protein particle comprises TNFSF14 and / or anti-CD3 svFc; the nucleotide sequence of the TNFSF14 is as shown in SEQ ID NO: 2; the nucleotide sequence of the anti-CD3 svFc is as shown in SEQ ID NO: 3; and / or a nucleotide sequence which has the homology of 90%-100% with the nucleotide sequence of the target fragment and is used for coding protein with the same function. By constructing a multi-target fragment with a specific sequence, a fusion peptide and a specific fusion mode, double-expression protein plasmids are formed, infiltration and penetration of T cells to a tumor microenvironment can be increased, and the T cells are combined with enhancement of the activity of the T cells, so that the anti-tumor capability of the T cells is enhanced.

The present application relates to the technical field of biological medicine, in particular to a kind of nano-molecular probe with targeting and its preparation method and application.The plasmid of immune checkpoint corresponding receptor of stable expression tumor surface negative regulation molecule is synthesized in the present application, which is prepared into targeted nano-molecular probe with cell membrane nanocapsule of enhancing T cell activity ligand and being marked with fluorescence, and melanin nanosphere of simultaneously loading therapeutic drug.The targeted nano-molecular probe provided in the present application can be long-circulated in vivo, reduce the dosage and administration frequency of chemotherapeutic drug.It also has the advantages of improving the drug resistance of tumor site to therapeutic drug, targeting tumor DNA damage and significantly enhancing the infiltration and activation of immune cells in tumor site.

The application discloses a preparation method of hydroxyl nano-aluminum oxide with controllable hydroxyl content, and relates to the technical field of inorganic functional material preparation. The method comprises the following steps: performing online gasification purification of an organic aluminum precursor in a closed integrated reaction system; guiding the online gasification purified organic aluminum precursor into a hydrolysis-hydrothermal crystallization reaction zone through a gas phase transportation channel, performing a controlled hydrolysis reaction, and generating amorphous aluminum hydroxide sol; sealing the hydrolysis-hydrothermal crystallization reaction zone, performing hydrothermal treatment on the amorphous aluminum hydroxide sol, and crystallizing the amorphous aluminum hydroxide into hydroxyl nano-aluminum oxide; and recovering and drying the hydroxyl nano-aluminum oxide. The application solves the fundamental contradiction between the improvement of material chemical purity and the maintenance of surface functional hydroxyl in the prior art, avoids the damage of traditional acid washing or calcination to the hydroxyl, and significantly improves the dispersibility, interface bonding force and electrolyte wettability of the material in the field of lithium ion batteries.

The application discloses a nitrogen-doped carbon lithium-sulfur battery positive electrode carrier material with directional pores and iron monatomic anchoring, and a preparation method and application thereof, and belongs to the technical field of lithium-sulfur battery positive electrode materials. Graphene oxide and cellulose nanofibers are dispersed in water to form a dispersion liquid; a mixed metal salt solution prepared by zinc salt and iron salt is added to the dispersion liquid, and a composite hydrogel is formed through electrostatic self-assembly; the composite hydrogel is placed on a pre-cooled metal substrate to perform directional freezing and freeze-drying, and an aerogel precursor with a directional pore structure is obtained; the aerogel precursor is subjected to programmed temperature carbonization with a solid nitrogen source, and a nitrogen-doped carbon lithium-sulfur battery positive electrode carrier material with directional pores and iron monatomic anchoring is obtained. Through the cooperation of directional freezing and gas-phase doping, vertical through pores are constructed, and iron monatomic atoms are anchored, the shuttle effect is inhibited, high specific capacity, excellent rate and long cycle life are realized, and the capacity retention rate reaches 88.5% after 600 cycles at 0.1C.

The invention relates to the field of biological pharmacy, in particular to a drug-loaded nano-cluster, a preparation method and application thereof. The invention provides a drug-loaded nano-cluster. The drug-loaded nano-cluster comprises a nano-cluster and an anti-tumor drug, the mass ratio of the nanocluster to the anti-tumor drug is (92.00 to 92.32) to (7.68 to 8.00). According to the cobalt-based drug-loaded nano-cluster for delivering the lenvatinib, the drug-loaded characteristic and immunogenicity of ovalbumin and cobalt ion-mediated metal immunity are utilized, so that the immunosuppression microenvironment of hepatocellular carcinoma is improved, the treatment effect of the lenvatinib is improved, and the drug resistance is reduced; a novel immune activation scheme is formed by combining with a PD-1 monoclonal antibody and is used for systemic drug therapy, and the immunotherapy curative effect of hepatocellular carcinoma is enhanced.

The application discloses a modified unsaturated polyester resin, raw materials of which comprise 1,2-propylene glycol 20-30 parts by mass, diethylene glycol 2-10 parts, ethylene terephthalate 15-30 parts, ethylene glycol 5-10 parts, phthalic anhydride 25-30 parts, maleic anhydride 2-8 parts, artificial stone aggregate 20-40 parts, amino-terminated polyamide amine 5-15 parts, activated calcium carbonate 100-200 parts, styrene 20-30 parts, catalyst 0.1-1 part, polymerization inhibitor 1-2 parts and antioxidant 2-5 parts. The application discloses a preparation method of the modified unsaturated polyester resin. The modified unsaturated polyester resin obtained by the application has good fluidity, can accommodate more calcium carbonate powder for infiltration, effectively reduces the cost of artificial stone products, has high bending strength and compression strength, and can meet the performance requirement of artificial stone.

The application discloses an aptamer-based functionalized nano linker, a preparation method and application, wherein the functionalized nano linker comprises a functionalized nano vesicle as a carrier, the functionalized nano vesicle is a biological nano membrane vesicle prepared through combination treatment of an ICD functionalized biological membrane and a biological membrane carrying an azido group; part of the azido groups of the biological nano membrane vesicle are loaded with an aptamer I for targeting DC cells through alkyne-azido cycloaddition reaction, and the other part of the azido groups are loaded with an aptamer II for targeting T cells through alkyne-azido cycloaddition reaction. The application designs a dual-specific functionalized nano linker, which can simultaneously target and link DC and T cells, the functionalized nano vesicle as the carrier itself has key proteins of ICD effect, can promote maturation of the dendritic cells and antigen cross-presentation, after linking with the T cells, can effectively activate the CD8+ T cells and differentiate the CD8+ T cells to cytotoxicity effect phenotype, and enhance killing of tumor cells.