Method for preparing acetylated hyaluronic acid

A technology of hyaluronic acid and sodium hyaluronate, which is applied in the field of preparation of acetylated hyaluronic acid, and can solve the problems of complex production steps and low yield

Inactive Publication Date: 2019-11-19
SHANDONG GALAXY BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a method for preparing acetylated hyaluronic acid, which solves the problems of complicated production steps and low yield

Method used

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  • Method for preparing acetylated hyaluronic acid

Examples

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no. 1 example

[0034] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0035] In describing the present invention, it is to be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "surrounding" etc. Indicating orientation or positional relationship is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in...

no. 2 example

[0059] A method for preparing acetylated hyaluronic acid also includes the following steps:

[0060] S1. Prepare materials: prepare formamide solvent, sodium hyaluronate and acetic anhydride;

[0061] S2. Dissolving: put the formamide solvent prepared in S1 into a container, then disperse the sodium hyaluronate prepared in S1 into the container containing the formamide solvent, and dissolve;

[0062] S3, adding: adding the acetic anhydride in S1 to the solvent container containing sodium hyaluronate and formamide in S2;

[0063] S4. Stirring: the sodium hyaluronate, formamide solvent and acetic anhydride in the S3 container are discharged into the interior of the mixer, and the sodium hyaluronate, formamide solvent and acetic anhydride are stirred and reacted by the mixer to form a new product ;

[0064] S5. Precipitation: the sodium hyaluronate, formamide solvent and acetic anhydride stirred in the mixer in S4 are stirred and reacted to form a new product to be precipitated...

no. 3 example

[0075] A method for preparing acetylated hyaluronic acid also includes the following steps:

[0076] S1. Prepare materials: prepare formamide solvent, sodium hyaluronate and acetic anhydride;

[0077] S2. Dissolving: put the formamide solvent prepared in S1 into a container, then disperse the sodium hyaluronate prepared in S1 into the container containing the formamide solvent, and dissolve;

[0078] S3, adding: adding the acetic anhydride in S1 to the solvent container containing sodium hyaluronate and formamide in S2;

[0079] S4. Stirring: the sodium hyaluronate, formamide solvent and acetic anhydride in the S3 container are discharged into the interior of the mixer, and the sodium hyaluronate, formamide solvent and acetic anhydride are stirred and reacted by the mixer to form a new product ;

[0080] S5. Precipitation: the sodium hyaluronate, formamide solvent and acetic anhydride stirred in the mixer in S4 are stirred and reacted to form a new product to be precipitated...

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Abstract

The invention discloses a method for preparing acetylated hyaluronic acid. The method comprises the following steps: S1. material preparation: preparing a formamide solvent of different volumes, sodium hyaluronate and acetic anhydride; S2, dissolving: placing the formamide solvent prepared in the step S1 in a container, dispersing the sodium hyaluronate prepared in the step S1 into the container containing the formamide solvent, and carrying out dissolving; S3, addition: adding the acetic anhydride prepared in the step S1 into the container containing the sodium hyaluronate and the formamide solvent prepared in the step S2; and S4, stirring: discharging the sodium hyaluronate, the formamide solvent and the acetic anhydride in the container prepared in the step S3 into a mixer. The method belongs to the field of biochemical technology. The method for preparing acetylated hyaluronic acid is simple in process, convenient to operate, high in yield, greatly reduced in production cost, and low in the degree of damage to molecules. After the addition of an acetyl group, the water retention and moisturizing effects of original sodium hyaluronate can be greatly improved.

Description

technical field [0001] The invention relates to the field of biochemical technology, in particular to a method for preparing acetylated hyaluronic acid. Background technique [0002] Sodium hyaluronate, also known as sodium hyaluronate, is a polysaccharide composed of disaccharide repeating units of glucuronic acid and glucosamine, widely distributed in connective tissues such as skin, vitreous body, umbilical cord, cartilage, and joint synovial fluid. And play a physiological role in moisturizing, nourishing, repairing and preventing damage; by adding acetyl groups to the structure of hyaluronic acid, its biological activity is significantly different, the solution has good elasticity, moisturizing and lubricating functions, and is widely used in cosmetics Moisturizing cosmetics, ophthalmic surgery emollients and lubricants for bone and joint lubrication, the moisturizing property is greatly enhanced, and it is easier to be absorbed by the body. When used externally, it ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/0072
Inventor 魏长龙杨艮孙雯雯泉学洪孙婷婷史建勋周大伟田业浩王晓徐振帅
Owner SHANDONG GALAXY BIO TECH
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