Eldecalcitol soft capsule and preparing method thereof
A technology of idecalcidol and soft capsules is applied in the directions of capsule delivery, bone diseases, pharmaceutical formulations, etc., to achieve the effects of convenient operation, good stability and beautiful appearance
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[0049] Its preparation method comprises the following steps:
[0050] (1) Weighing: weigh idecalcitol, dibutylphenol, medium chain triglycerides, gelatin, glycerin, tartrazine, titanium dioxide, purified water;
[0051] (2) Dosing: dissolve dibutylphenol and idecalcitol in medium-chain triglycerides, sieve, and set aside; dissolve tartrazine in an appropriate amount of purified water, stir to dissolve, sieve, and set aside; disperse titanium dioxide Add an appropriate amount of purified water, sieve, and set aside;
[0052] (3) Chemical glue: add an appropriate amount of purified water to the chemical glue tank, heat to 60-80°C, add glycerin and stir to completely dissolve, then add gelatin to dissolve, add tartrazine solution and titanium dioxide dispersion after fully dissolved, heat and stir, Disperse evenly, vacuum 0.06~0.1Mpa, remove air bubbles for 20~120min;
[0053] (4) Pill making: heat preservation of the glue solution at 50-60°C, fill the above-mentioned medicinal...
Embodiment 1
[0069] A kind of idecalcitol soft capsule, its prescription is as follows:
[0070] Contents:
[0071] Idecalcitol 15mg main ingredient
[0072] Dibutylphenol 1g Antioxidant
[0073] Medium Chain Triglycerides 3kg Solvent
[0074] Bursa skin:
[0075]
[0076] Its preparation method comprises the following steps:
[0077] Weighing: weigh idecalcitol, dibutylphenol, medium chain triglycerides, gelatin, glycerin, tartrazine, titanium dioxide, purified water;
[0078] Dosing: Dissolve dibutylphenol and idecalcitol in medium-chain triglycerides, sieve, and set aside; dissolve tartrazine in an appropriate amount of purified water, stir to dissolve, sieve, and set aside; disperse titanium dioxide in an appropriate amount of purified water water, sieved, set aside;
[0079] Chemical glue: add an appropriate amount of purified water to the chemical glue tank, heat to 75°C, add glycerin and stir to dissolve completely, then add gelatin to dissolve, after fully dissolve, add le...
Embodiment 2
[0084] A kind of idecalcitol soft capsule, its prescription is as follows:
[0085] Contents:
[0086] Idecalcitol 150mg main ingredient
[0087] Dibutylphenol 10g Antioxidant
[0088] Medium Chain Triglycerides 30kg Solvent
[0089] Bursa skin:
[0090]
[0091] Its preparation method comprises the following steps:
[0092] Weighing: weigh idecalcitol, dibutylphenol, medium chain triglycerides, gelatin, glycerin, tartrazine, titanium dioxide, purified water;
[0093] Dosing: Dissolve dibutylphenol and idecalcitol in medium-chain triglycerides, sieve, and set aside; dissolve tartrazine in an appropriate amount of purified water, stir to dissolve, sieve, and set aside; disperse titanium dioxide in an appropriate amount of purified water water, sieved, set aside;
[0094] Chemical glue: add an appropriate amount of purified water to the chemical glue tank, heat to 67°C, add glycerin and stir to dissolve completely, then add gelatin to dissolve, after fully dissolve, add...
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