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Programmable neuromagnetic stimulation device

A magnetic stimulation and nerve technology, applied in the direction of using a variable magnetic field generated by mechanical motion, magnetic therapy, program control, etc., can solve the problem that the nerve magnetic stimulation device cannot be applied to various clinical symptoms of different disease models, and cannot be programmed, Intelligent, unable to accurately locate the cortex of the brain area, etc., to achieve the effect of rapid antidepressant effect and enhanced effect

Pending Publication Date: 2019-11-22
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Purpose of the invention: The technical problem to be solved by the present invention is that the prior art used for the study of nerve magnetic stimulation cannot be programmed and intelligentized, and the existing nerve magnetic stimulation device cannot be applied to various clinical symptoms of different disease models, and cannot be used for In-depth study of the impact of different forms of magnetic stimulation on nervous system diseases; another technical problem solved by the present invention is that the existing magnetic stimulation devices cannot accurately locate the cortex of specific brain regions, and cannot achieve deep brain region stimulation

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Examples

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Embodiment 1

[0037] Such as Figure 1~4 Shown is the three-dimensional structural diagram of the magnetic stimulation device, the magnetic stimulation device of the present invention includes a base, the base is provided with a rotating magnetic field generator 2, located above the device; the device is provided with a lifting platform 3, and a control panel is provided above 4. Equipped with superparamagnetic iron oxide nanoparticles for external use, the shell 5 of the magnetic stimulation device is made of light and strong engineering plastics or aluminum alloy, and the load-bearing parts are made of high-quality metal materials to ensure the stability of the device.

[0038]The rotating magnetic field generator 2 includes a magnetic head 9, a driving device 1 that is connected with the magnetic head 9 and drives the magnetic head 9 to rotate. The driving device 1 is connected with a single-chip control device, and the single-chip control device controls the rotating magnetic field gener...

Embodiment 2

[0049] The test subjects of this example are mice, and Ruicun granules are implanted into the targeted brain area of ​​the mice through precise positioning injection, and a magnetic stimulator is used to apply an external rotating magnetic field to the test subjects. Superparamagnetic iron oxide nanoparticles exhibit magnetic properties under the action of an external rotating magnetic field, and produce biological effects on the surrounding area.

[0050] (1) Establishment and grouping of animal models

[0051] Mice were 5-6 week old male C57BL / 6 mice (C57BL / 6J JAX TM mice strain), purchased from Shanghai Xipuer-Bikay Experimental Animal Co., Ltd. In a standard environment animal room (constant temperature 23±1°C; constant humidity 55±10%; day and night cycle 12h; self-eating and drinking water) to adapt to feeding for one week. After adaptation, chronic unpredictable stress (CUMS) model was used to establish depression model mice. The model mice were randomly divided int...

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Abstract

The invention discloses a programmable neuromagnetic stimulation device comprising a base and a rotating magnetic field generator arranged on the base; the rotating magnetic field generator comprisesa magnetic head and a driving device connected with the magnetic head and driving the magnetic head to rotate; the driving device is connected with a single-chip microcomputer, the single-chip microcomputer controls the magnetic field generator to generate a rotating magnetic field, and the magnetic field strength of the rotating magnetic field changes periodically with time. The magnetic field frequency is regulated by a motor rotating speed control system based on a single chip microcomputer encoder, and the programmable neuromagnetic stimulation device is applied to the field of neuromagnetic stimulation, realizes the programmable rhythm of neuromagnetic stimulation, and can be used for the related scientific research of neuromagnetic stimulation effect. Through the specific magnetic field rhythm, and with combination of superparamagnetic nanoparticles, the programmable neuromagnetic stimulation device can be better applied to known scientific research of magnetic stimulation effectin deep brain areas (such as hippocampus) related to depression.

Description

technical field [0001] The invention relates to a magnetic stimulation device, in particular to a programmable nerve magnetic stimulation device in the field of brain nerves. Background technique [0002] At present, the physical therapy of electromagnetic stimulation uses physical factors such as electric field or magnetic field to directly act on the relevant functional brain regions of the cerebral cortex, re-stimulate the electrophysiological activity of neurons under electromagnetic interference, and promote their transformation to a normal state to achieve therapeutic purposes. As a non-invasive physical factor, magnetic field can effectively induce neural function modulation and have a significant effect on neural activation in brain regions. On the other hand, electromagnetic stimulation has the advantages of being adjustable and reversible, and can be flexibly used in treatment, which has positive significance for improving the physical and mental health and pain of...

Claims

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Application Information

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IPC IPC(8): A61N2/12A61N2/00G05B19/042
CPCA61N2/006A61N2/12G05B19/0423
Inventor 孙剑飞姚驰蔡雯雯夏梦琴徐丽洪张志珺顾宁
Owner SOUTHEAST UNIV
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