Epimedium compound product quality control and fingerprint spectrum detection method

A fingerprint and product quality technology, which is applied in the field of epimedium compound product quality control and fingerprint detection, can solve problems such as being unfavorable to practical application, increasing quality control time and money cost, and increasing quality control difficulty.

Active Publication Date: 2019-11-26
甘肃琛蓝生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the diversity of ingredients contained in traditional Chinese medicine, quality control by adding indicators for content determination will incr

Method used

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  • Epimedium compound product quality control and fingerprint spectrum detection method
  • Epimedium compound product quality control and fingerprint spectrum detection method
  • Epimedium compound product quality control and fingerprint spectrum detection method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Embodiment 1 of the present invention discloses Epimedium compound product quality control and fingerprint spectrum detection method, and the technical scheme adopted is as follows:

[0097] Epimedium compound is composed of the following raw materials: 1200g of glucosamine, 400g of collagen, 200g of chondroitin sulfate, 350g of Chinese medicine extract; Cuscuta 17g.

[0098] (1) Perform product quality control and fingerprint detection on the extracts of traditional Chinese medicine:

[0099] S1, Icariin:

[0100] a. Preparation of standard solution, take 10mg of icariin standard in a 10ml volumetric flask, add methanol to dissolve, and constant volume;

[0101] b. Preparation of extract sample solution, take 0.1g of Epimedium extract, place it in a stoppered Erlenmeyer flask, add 50ml of methanol, weigh it, ultrasonically treat it for 30min, weigh it again, make up the lost weight with methanol, Shake well, filter, let stand, and take the supernatant;

[0102] c. ...

Embodiment 2

[0171] Embodiment 2 of the present invention discloses Epimedium compound product quality control and fingerprint spectrum detection method, and the technical scheme adopted is as follows:

[0172] Epimedium compound is composed of the following raw materials: 1200g of glucosamine, 400g of collagen, 200g of chondroitin sulfate, 350g of Chinese medicine extract; Cuscuta 15g.

[0173] (1) Perform product quality control and fingerprint detection on the extracts of traditional Chinese medicine:

[0174] S1, Icariin:

[0175] a. Preparation of standard solution;

[0176] b. Preparation of extract sample solution;

[0177] c. Content determination,

[0178] Standard curve creation: Dilute the standard solution by 1 / 2 gradient to obtain 5 concentration gradients, respectively 0.075, 0.15, 0.3, 0.6, and 1.2mg / ml, analyze according to the chromatographic conditions, and draw the standard curve;

[0179] According to the peak area of ​​the sample and the drawn standard curve, the ...

Embodiment 3

[0197] Embodiment 3 of the present invention discloses Epimedium compound product quality control and fingerprint spectrum detection method, and the technical scheme adopted is as follows:

[0198] Epimedium compound is composed of the following raw materials: glucosamine 2400g, collagen 800g, chondroitin sulfate 400g, Chinese medicine extract 700g; Cuscuta 70g.

[0199] (1) Perform product quality control and fingerprint detection on the extracts of traditional Chinese medicine:

[0200] S1, Icariin:

[0201] a. Preparation of standard solution;

[0202] b. Preparation of extract sample solution;

[0203] c. Content determination,

[0204] Standard curve creation: Dilute the standard solution by 1 / 2 gradient to obtain 5 concentration gradients, respectively 0.075, 0.15, 0.3, 0.6, and 1.2mg / ml, analyze according to the chromatographic conditions, and draw the standard curve;

[0205] According to the peak area of ​​the sample and the drawn standard curve, the content of ica...

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Abstract

The invention discloses an epimedium compound product quality control and fingerprint spectrum detection method. According to the method, high performance liquid chromatography is used; the quality control of a product containing traditional Chinese medicine components, especially the stable control of the quality of a product containing a large quantity of non-traditional Chinese medicine components can be effectively realized; with step-by-step quality control realized, the quality fluctuation of the product can be reduced, and quality stability can be guaranteed. The method is simple and convenient and does not need additional instruments, standard substances and the like. With the method adopted, cost can be saved, and actual production can be benefitted.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine analysis, in particular to a quality control and fingerprint detection method of epimedium compound products. Background technique [0002] The invention relates to a product quality control method and fingerprints, in particular to a method for controlling product quality through content measurement and fingerprints. The content determination of index components refers to the use of high performance liquid chromatography to detect the content of the corresponding standard products and test products, and calculate the content of the substance in the test products through the content of the standard products. It is a common method for quality control of traditional Chinese medicine related products. . [0003] Fingerprint of traditional Chinese medicine refers to a set of images, graphs, spectral spectra and data that can show the chemical characteristics of Chinese medicinal materials ...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/74G01N30/86
CPCG01N30/06G01N30/74G01N30/8686Y02P90/30G01N30/04G01N30/34G01N2030/027G01N2030/047
Inventor 邹圣灿李莉宗磊宗建成王尚龙张曾亮
Owner 甘肃琛蓝生物科技有限公司
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