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Cefoperazone sodium for injection and preparation method thereof

A technology for cefoperazone sodium and injection, applied in the field of medicine, can solve problems such as poor effect

Active Publication Date: 2021-12-03
湖北美林药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cefoperazone sodium (Cefoperazone sodium) Cefoperazone is a third-generation cephalosporin, which is effective against Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Salmonella typhi, Shigella, and Citrobacter Bacteria and Pseudomonas aeruginosa have good antibacterial effect, but have poor effect on Enterobacter aerogenes, Enterobacter cloacae, Salmonella typhimurium and Acinetobacter spp.

Method used

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  • Cefoperazone sodium for injection and preparation method thereof
  • Cefoperazone sodium for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Preparation of Cefoperazone Sodium for Injection (Specification: 0.5g)

[0044] prescription:

[0045] Cefoperazone Sodium: 500g

[0046] Sodium citrate: 12g

[0047] Povidone K30: 10g

[0048] Add water for injection to 2000ml

[0049] Make 1000 pieces

[0050] The preparation method of cefoperazone sodium for injection of the present invention comprises the following steps:

[0051] (1) Add the prescribed amount of sodium citrate, povidone K30, and cefoperazone sodium into 1200ml of water for injection in turn, stir and dissolve, add water for injection to 2000ml, and stir evenly;

[0052] (2) Filter the solution in step (1) through a 0.22 μm microporous membrane, measure the pH value and content of the filtrate, determine the filling volume according to the specifications, and divide into half-stoppered liquid;

[0053] (3) Freeze-drying:

[0054] ①Pre-freezing: put the aliquot in a freezer that has been cooled to -36°C in advance, and keep it for 3 ...

Embodiment 2

[0057] Example 2 Preparation of Cefoperazone Sodium for Injection (Specification: 0.5g)

[0058] prescription:

[0059] Cefoperazone Sodium: 500g

[0060] Sodium citrate: 12g

[0061] Povidone K30: 10g

[0062] Add water for injection to 2000ml

[0063] Made 1000 pieces

[0064] The preparation method of cefoperazone sodium for injection of the present invention comprises the following steps:

[0065] (1) Add the prescribed amount of sodium citrate, povidone K30, and cefoperazone sodium into 1200ml of water for injection in turn, stir and dissolve, add water for injection to 2000ml, and stir evenly;

[0066] (2) Filter the solution in step (1) through a 0.22 μm microporous membrane, measure the pH value and content of the filtrate, determine the filling volume according to the specifications, and divide into half-stoppered liquid;

[0067] (3) Freeze-drying:

[0068] ① Pre-freezing: place the aliquot in a freezer that has been cooled to -24°C in advance, and keep it for...

Embodiment 3

[0071]Example 3 Preparation of Cefoperazone Sodium for Injection (Specification: 0.5g)

[0072] prescription:

[0073] Cefoperazone Sodium: 500g

[0074] Sodium citrate: 12g

[0075] Povidone K30: 10g

[0076] Add water for injection to 2000ml

[0077] Made 1000 pieces

[0078] The preparation method of cefoperazone sodium for injection of the present invention comprises the following steps:

[0079] (1) Add the prescribed amount of sodium citrate, povidone K30, and cefoperazone sodium into 1200ml of water for injection in turn, stir and dissolve, add water for injection to 2000ml, and stir evenly;

[0080] (2) Filter the solution in step (1) through a 0.22 μm microporous membrane, measure the pH value and content of the filtrate, determine the filling volume according to the specifications, and divide into half-stoppered liquid;

[0081] (3) Freeze-drying:

[0082] ① Pre-freezing: put the aliquot in a freezer that has been cooled to -30°C in advance, and keep it for 3....

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PUM

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Abstract

The invention relates to cefoperazone sodium for injection and a preparation method thereof, and belongs to the technical field of medicine. The cefoperazone sodium for injection is prepared by adding 500g to 2000g of cefoperazone sodium, sodium citrate, povidone K30, adding 2000ml of water for injection and then freeze-drying. The cefoperazone sodium for injection obtained by the invention has good quality and high stability, is superior to the prior art, and greatly improves the effectiveness and safety of the cefoperazone sodium for injection in clinical use.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to cefoperazone sodium for injection and a preparation method thereof. Background technique [0002] Cefoperazone sodium (Cefoperazone sodium) Cefoperazone is a third-generation cephalosporin, which is effective against Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Salmonella typhi, Shigella, and Citrobacter Bacteria and Pseudomonas aeruginosa have good antibacterial effects, but have poor effects on Enterobacter aerogenes, Enterobacter cloacae, Salmonella typhimurium and Acinetobacter spp. Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis are highly sensitive to this product. This product also has good effects on various groups of streptococci and pneumococci, only moderately effective on staphylococci (methicillin-sensitive strains), and enterococci are drug-resistant. Cefoperazone has a good effect on most Gram-positive anaerobic bact...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K47/12A61K47/32A61K31/546A61P31/04
CPCA61K9/0019A61K9/19A61K31/546A61K47/12A61K47/32A61P31/04
Inventor 胡成忠
Owner 湖北美林药业有限公司
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