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A kind of ginkgo biloba composition and preparation method

A technology of ginkgo biloba and composition, which is applied in the field of ginkgo biloba composition and preparation, can solve problems such as limited synergistic effect, influence on drug efficacy, complex components of ginkgo leaf extract, etc., and achieve enhanced synergistic effect, improved drug effect, and improved biological The effect of utilization

Active Publication Date: 2021-11-30
FEIMA PHARMA NANTONG CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the complex components of the Ginkgo biloba extract in the prior art, the limited synergistic effect between the components in the same system, which affects the efficacy, and then provide a Ginkgo biloba composition and preparation method, the ginkgo leaf composition cooperates and cooperates with various raw materials, so that most of the components of different polarities in the ginkgo leaf extract are dissolved in the same system, the synergistic effect between the components is enhanced, and the drug effect is improved.

Method used

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  • A kind of ginkgo biloba composition and preparation method
  • A kind of ginkgo biloba composition and preparation method
  • A kind of ginkgo biloba composition and preparation method

Examples

Experimental program
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Embodiment 1

[0023] The preparation of embodiment 1 Ginkgo biloba extract

[0024] This embodiment provides a preparation method of ginkgo leaf extract, comprising the steps of: taking ginkgo leaves and pulverizing them into 30-40 meshes, and extracting by warm immersion in 75% ethanol solution with a volume concentration 3 times the weight (equivalent to the weight of ginkgo leaves) 1 time, 3 hours each time, recover ethanol, concentrate to a relative density of 1.04-1.08 (thermal measurement), then add 3 times the weight of water (equivalent to the weight of ginkgo leaves) to stir, refrigerate at 6°C for 8 hours, filter, and put the obtained filtrate on a large Pore ​​adsorption resin column, with water, volume concentration is 20% ethanol solution, volume concentration is elution respectively, and volume concentration is the eluent of 65% ethanol, and temperature is 50-60 ℃, and vacuum degree (- 0.08~-0.1MPa) concentrated under reduced pressure and dried to obtain.

Embodiment 2

[0025] The preparation of embodiment 2 Ginkgo biloba extract

[0026] This embodiment provides a preparation method of ginkgo leaf extract, comprising the steps of: taking ginkgo leaves and pulverizing them into 30-40 meshes, and extracting by warm immersion in 65% ethanol solution with a volume concentration of 9 times the weight (equivalent to the weight of ginkgo leaves) 3 times, 1 hour each time, recover ethanol, concentrate to a relative density of 1.04-1.08 (thermal measurement), then add 6 times the weight of water (equivalent to the weight of ginkgo leaves) to stir, refrigerate at 2°C for 16 hours, filter, and put the resulting filtrate on a large Pore ​​adsorption resin column, with water, volume concentration is 10% ethanol solution, volume concentration is 75% ethanol solution elution respectively, and collection volume concentration is the eluent of 75% ethanol, and temperature is 50-60 ℃, and vacuum degree (- 0.08~-0.1MPa) concentrated under reduced pressure and d...

Embodiment 3

[0027] The preparation of embodiment 3 Ginkgo biloba extract

[0028] The present embodiment provides a preparation method of ginkgo leaf extract, comprising the steps of: getting ginkgo leaves and pulverizing them into 30-40 meshes, and using 7 times and 5 times the weight (equivalent to ginkgo leaf weight) volume concentration 70% ethanol respectively Each solution was warm-immersed and extracted twice, each time for 2 hours, recovered ethanol, concentrated to a relative density of 1.04-1.08 (thermal measurement), then added 4 times the weight of water (equivalent to the weight of ginkgo leaves) and stirred for 30 minutes, refrigerated at 4°C for 12 hours, filtered , the obtained filtrate is put on the macroporous adsorption resin column, and water, volume concentration is 15% ethanol solution, and volume concentration is 70% ethanol solution elution respectively, and collection volume concentration is the eluent of 70% ethanol, and temperature is 50-60 ℃, vacuum degree (-0....

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Abstract

A kind of Ginkgo biloba composition and preparation method provided by the present invention, comprise following raw material: Ginkgo biloba extract, microcrystalline cellulose, lactose, pregelatinized starch, croscarmellose sodium, silicon dioxide and ethanol solution , by selecting the combination of Ginkgo biloba extract and the above-mentioned auxiliary materials to cooperate synergistically, the components of different properties can be dissolved in the same reaction system after the prepared Ginkgo biloba composition enters the human body, the synergistic effect between the components is enhanced, and the drug effect is improved. At the same time, the above-mentioned ginkgo leaf composition also has relatively ideal granule fluidity, hardness, friability and disintegration time limit, and has certain stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a ginkgo leaf composition and a preparation method. Background technique [0002] Ginkgo biloba leaves are the dried leaves of Ginkgo biloba L., a plant of the family Ginkgoaceae, harvested in autumn when the leaves are still green, and dried in time. Ginkgo biloba extracts and preparations are widely used in clinics, and have pharmacological effects such as expanding cardiovascular and cerebrovascular, improving microcirculation, anti-platelet activating factor, anti-oxidation, anti-virus, anti-bacterial and anti-inflammatory. Clinically, it is mainly used for senile dementia, hyperlipidemia, coronary heart disease, chronic bronchitis, sequelae of traumatic brain injury, cerebral embolism, cerebral vasospasm, paralysis agitans, arteritis of lower extremities, etc. [0003] The main active substances in Ginkgo biloba extract are ginkgo flavonoids and ginkgo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/26A61K47/36A61K47/04A61K47/10A61K47/14A61K47/12A61K47/44A61K47/24A61K36/16A61K9/28A61K127/00
CPCA61K9/2009A61K9/2013A61K9/2018A61K9/2031A61K9/2054A61K9/2059A61K36/16A61K2236/333A61K2236/51A61K2236/53A61K2236/55A61P3/06A61P7/02A61P9/10A61P9/14A61P11/00A61P25/00A61P25/16A61P25/28
Inventor 徐仁华
Owner FEIMA PHARMA NANTONG CITY
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