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Furosemide tablets and preparation method thereof

A furosemide tablet and a technology for furosemide are applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve the cumbersome method of furosemide tablets and the drug resistance of human body. , increasing production costs and other issues, to avoid drug resistance, reduce production costs, and simplify complex effects

Inactive Publication Date: 2019-12-06
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Taking an existing drug for a long time will easily cause the body to develop drug resistance, which will lead to little effect after taking the same drug in the future. Similarly, the existing methods for preparing furosemide tablets are relatively cumbersome, resulting in increased production costs

Method used

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  • Furosemide tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A furosemide tablet, the furosemide tablet is made up of the following raw materials in parts by weight:

[0030] 25 parts of furosemide, 16.75 parts of corn starch, 55 parts of lactose, 27 parts of purified water, 1 part of sodium carboxymethyl starch and 1 part of magnesium stearate.

[0031] A kind of furosemide sheet, concrete preparation method step is as follows:

[0032] S1. Weigh the required furosemide, cornstarch, lactose, sodium carboxymethyl starch and magnesium stearate, and carry out dry mixing treatment;

[0033] S2. Melting cornstarch in purified water, adding it to the dry-blended material in S1, and performing granulation;

[0034] S3, placing the granulated particles in a drying device for drying treatment;

[0035] S4, put the dried particles into the granulator for granulation processing;

[0036] S5. Add 30 mesh sodium carboxymethyl starch, 30 mesh magnesium stearate, and supplemented 30 mesh cornstarch to the sized granules, put them into the m...

Embodiment 2

[0044] A furosemide tablet, the furosemide tablet is made up of the following raw materials in parts by weight:

[0045] 25 parts of furosemide, 18 parts of corn starch, 55 parts of lactose, 29 parts of purified water, 1.5 parts of sodium carboxymethyl starch and 1.1 parts of magnesium stearate.

[0046] A kind of furosemide sheet, concrete preparation method step is as follows:

[0047] S1. Weigh the required furosemide, cornstarch, lactose, sodium carboxymethyl starch and magnesium stearate, and carry out dry mixing treatment;

[0048] S2. Melting cornstarch in purified water, adding it to the dry-blended material in S1, and performing granulation;

[0049] S3, placing the granulated particles in a drying device for drying treatment;

[0050] S4, put the dried particles into the granulator for granulation processing;

[0051] S5. Add 30 mesh sodium carboxymethyl starch, 30 mesh magnesium stearate, and supplemented 30 mesh cornstarch to the sized granules, put them into th...

Embodiment 3

[0059] A furosemide tablet, the furosemide tablet is made up of the following raw materials in parts by weight:

[0060] Furosemide 23-25 ​​parts, corn starch 17-19 parts, lactose 55-59 parts, purified water 27-30 parts, carboxymethyl starch sodium 0.4-2 parts and magnesium stearate 0.5-1.3 parts.

[0061] A kind of furosemide sheet, concrete preparation method step is as follows:

[0062] S1. Weigh the required furosemide, cornstarch, lactose, sodium carboxymethyl starch and magnesium stearate, and carry out dry mixing treatment;

[0063] S2. Melting cornstarch in purified water, adding it to the dry-blended material in S1, and performing granulation;

[0064] S3, placing the granulated particles in a drying device for drying treatment;

[0065] S4, put the dried particles into the granulator for granulation processing;

[0066] S5. Add 30 mesh sodium carboxymethyl starch, 30 mesh magnesium stearate, and supplemented 30 mesh cornstarch to the sized granules, put them into th...

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Abstract

The invention discloses furosemide tablets and a preparation method thereof. The furosemide tablets comprise raw materials in parts by weight as follows: 23-25 parts of furosemide, 16-20 parts of cornstarch, 50-60 parts of lactose, 26-32 parts of purified water, 0.2-2 parts of sodium carboxymethyl starch and 0.5-1.5 parts of magnesium stearate. The specific preparation method of the furosemide tablets comprises the steps as follows: S1, weighing required furosemide, corn starch, lactose, sodium carboxymethyl starch and magnesium stearate, and performing dry mixing treatment; and S2, dissolving the corn starch in the purified water, adding the solution to a dry-mixed material in the S1, and performing granulation treatment. The furosemide, the corn starch, the lactose, the purified water,sodium carboxymethyl starch and magnesium stearate are mixed and matched in proportion and processed into tablets to further replace treatment effects of existing furosemide tablets, so that treatmentdrugs are more diversified, and drug resistance of bodies due to long-term use of existing drugs is avoided. The preparation method simplifies complex pharmaceutical processes before and reduces theproduction cost.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a furosemide tablet and a preparation method thereof. Background technique [0002] Furosemide tablets, indications are 1. Edema disease 2. Hypertension 3. Prevention of acute renal failure, 4. Hyperkalemia and hypercalcemia 5. Dilutional hyponatremia, especially when blood sodium When the concentration is lower than 120mmol / L 6. Hypersecretion of antidiuretic hormone 7. Acute drug poisoning, etc. [0003] Taking an existing drug for a long time can easily cause the body to develop drug resistance, which in turn leads to little effect of subsequent administration of the same drug. Similarly, the existing methods for preparing furosemide tablets are relatively cumbersome, resulting in increased production costs. [0004] In order to solve the above problems, the present application proposes a furosemide tablet and a preparation method thereof. Contents of the invention [0005] Techni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K47/26A61K31/341A61P7/10A61P13/12A61P9/12
CPCA61K9/2018A61K9/2059A61K31/341A61P7/10A61P9/12A61P13/12
Inventor 高煜
Owner HUAYI PHARMA ANHUI CO LTD
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