Viral delivery of neoantigens

An antigen, adenovirus technology, applied in the direction of viruses, cancer antigen components, viruses/phages, etc., can solve the problems of missing candidate neoantigen somatic mutations, inefficient use of vaccines or autoimmune risks.
CN110545810APending Publication Date: 2019-12-06GRITSTONE BIO INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GRITSTONE BIO INC
Publication Date
2019-12-06

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Abstract

Disclosed herein are chimpanzee adenoviral vectors that include neo-antigen encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
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Description

[0001] Cross references to related applications

[0002] This application requires U.S. Provisional Application No. 62 / 425,996 filed on November 23, 2016; U.S. Provisional Application No. 62 / 435,266 filed on December 16, 2016; U.S. Provisional Application No. 62 / 435,266 filed on May 8, 2017 Application No. 62 / 503,196; and U.S. Provisional Application No. 62 / 523,212 filed on June 21, 2017, each of which is incorporated herein by reference in its entirety.

[0003] Sequence Listing

[0004] This application contains a sequence listing, which has been submitted by EFS-Web and is incorporated herein by reference in its entirety. The ASCII copy created in XX, 20XX is named XXXXXUS_sequencelisting.txt, and the size is X,XXX,XXX bytes. Background technique

[0005] Therapeutic vaccines based on tumor-specific neoantigens have great prospects as the next generation of personalized cancer immunotherapy. 1-3 Considering that the possibility of new antigen production is relatively greater, canc...

Claims

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