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Sitagliptin phosphate pharmaceutical composition and preparation method thereof

A technology for sitagliptin phosphate and composition, which is applied in the field of sitagliptin phosphate pharmaceutical composition and preparation thereof, can solve the problems of not introducing coating in detail, affecting the performance of the sitagliptin phosphate pharmaceutical composition, and the like, and achieves the One-sided smooth and beautiful, improved compliance, good stability

Active Publication Date: 2019-12-13
YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the specific steps of coating are not described in detail in this preparation method, and the specific steps of coating will affect the performance of the prepared sitagliptin phosphate pharmaceutical composition

Method used

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  • Sitagliptin phosphate pharmaceutical composition and preparation method thereof
  • Sitagliptin phosphate pharmaceutical composition and preparation method thereof
  • Sitagliptin phosphate pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0030] Embodiment 1-3 adopts following preparation method, comprises the following steps:

[0031] A) get sitagliptin phosphate, microcrystalline cellulose, anhydrous dicalcium phosphate anhydrous, disintegrant and lubricant in formula quantity, adopt powder direct compression method to make tablet core;

[0032] B) Take the liquid plasticizer of the formula quantity and mix it at 45°C, and put it into the liquid spray gun; mix the talc powder and the colorant of the formula quantity at 50°C, and put it into the powder spray gun;

[0033] C) Preheating the tablet core in step A) in a rotary coating pan, controlling the temperature to 45° C., and then spraying the coating pan with a liquid spray gun and a powder spray gun respectively to obtain coated tablets;

[0034] D) The coated tablet is kept at 45° C. for 72 hours, solidified to form a film, and the sitagliptin phosphate pharmaceutical composition is obtained.

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PUM

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Abstract

The invention belongs to the technical field of natural medicine extraction, and particularly relates to an efficient extraction method of asparagus root saponin. The method is realized through the following steps: (1) asparagus root pretreatment; (2) primary homogenization; (3) compound enzymolysis; (4) secondary homogenization; (5) concentrating and drying; (6) extracting; and (7) alcohol precipitation. According to the method, the utilization value of the asparagus roots can be improved, and resource reutilization is achieved; the asparagus root saponin extracted by the method is high in extraction rate, and meanwhile, the prepared saponin is good in stability and high in purity.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a sitagliptin phosphate pharmaceutical composition and a preparation method thereof. Background technique [0002] Type 2 diabetes is a metabolic disease caused by the body not producing enough insulin or not using it well. With the increasing incidence of type 2 diabetes, sitagliptin phosphate has become more and more popular as a new antidiabetic drug. [0003] Sitagliptin phosphate, white solid powder, soluble in water, slightly soluble in ethanol, acetone and acetonitrile. Tablets are tablet-shaped preparations made of drugs and excipients through a certain preparation process. They have the advantages of large output, small size, variety, small impact, high degree of mechanization, low cost, accurate dosage, convenient carrying and taking, and good stability. features. At present, known methods for preparing sitagliptin phosphate pharmaceutical co...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K47/14A61K31/4985A61P3/10
CPCA61K9/2813A61K9/282A61K31/4985A61P3/10
Inventor 任亚东夏春森刘志强朱春水蔡乐袁海成
Owner YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD
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