Traditional Chinese medicinal composition with prevention and treatment of hyperuricemia, and preparation method and application thereof

A technology for hyperuricemia and a composition is applied in the field of traditional Chinese medicine compositions for preventing and treating hyperuricemia and the field of preparation thereof, which can solve the problems of inability to take for a long time, toxic and side effects, etc. good effect

Active Publication Date: 2019-12-13
南京海峪生物科技有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] At present, the classic drugs for the treatment of hyperuricemia are Western medicines such as allopurinol and benzbromarone. Although the effect of lowering blood uric acid is rapid, they have relatively toxic and side effects on the liver and kidneys and cannot be taken for a long time.
The

Method used

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  • Traditional Chinese medicinal composition with prevention and treatment of hyperuricemia, and preparation method and application thereof
  • Traditional Chinese medicinal composition with prevention and treatment of hyperuricemia, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Blood uric acid lowering experiment

[0020] 1. Sample preparation

[0021] 1.1 Positive control: allopurinol tablets;

[0022] 1.2 Extract of traditional Chinese medicine prescription: Take 5 parts of plantain, 6 parts of purslane, 4 parts of Smilax smilax and 4 parts of coix seed, add up to 10 times the weight of the medicinal materials and decoct to extract 3 times, each time for 30 minutes, The water extracts were combined, concentrated under reduced pressure at 60°C to 2 g crude drug / ml, and the extract of the Chinese medicine composition sample was obtained.

[0023] 1.3 Traditional Chinese medicine control extract: Take 6 parts of Atractylodes atractylodes, 5 parts of Plantain, 4 parts of Smilax cocos and 4 parts of Coix Seed, add up to 10 times the weight of the medicinal materials and decoct them in water for 3 times, each time for 30 minutes, combine the water to extract solution, and concentrated under reduced pressure at 60°C to 2g crude drug / ml ...

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Abstract

The present invention discloses a traditional Chinese medicinal composition with prevention and treatment of hyperuricemia, and a preparation method and an application thereof. The traditional Chinese medicinal composition is prepared from 1-6 parts of plantain herb, 1-6 parts of herba portulacae, 1-4 parts of rhizoma smilacis glabrae and 1-4 parts of coix seeds. The provided composition consistsof a large number of raw materials through a large number of experiments. Results of animal model experiments show that the traditional Chinese medicinal composition can significantly reduce uric acid in a hyperuricemia rat model and shows good uric acid-lowering activity. In addition, the raw materials are medicinally and edibly homogeneous, good in safety, and free of obvious toxic and side effects. Besides, the composition can be easily prepared into tablets, capsules, solid dispersions, drip pills and other solid preparation drugs or health-care products with a carrier.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition capable of preventing and treating hyperuricemia, a preparation method and application thereof. Background technique [0002] Hyperuricemia is a metabolic syndrome caused by long-term purine metabolic disorder or decreased excretion of uric acid. It is the most important biochemical basis of gout, and it is the second largest metabolic disease after diabetes, with a high incidence. In 2013, the Endocrinology Society of the Chinese Medical Association pointed out in the "Chinese Expert Consensus on Hyperuricemia and Gout Treatment" that the incidence of hyperuricemia in my country is increasing year by year, especially in economically developed cities and coastal areas. The disease rate reaches 5%-23.5%, which is close to the level of western developed countries. [0003] At present, the classic drugs for the treatment of hype...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K36/90A61P19/06
CPCA61K36/68A61K36/185A61K36/90A61K36/896A61K36/8994A61P19/06A61K2300/00
Inventor 海添
Owner 南京海峪生物科技有限公司
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