Hepatitis C fibrosis characteristic information extraction method and device
A technology for collecting hepatitis C liver fiber and characteristic information, which is applied in the field of medical information processing, and can solve the problems of difficult acquisition of collagen parameters for identifying progress and regression and/or prognosis, and difficult treatment process.
Active Publication Date: 2019-12-20
PEOPLES HOSPITAL PEKING UNIV +1
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Problems solved by technology
Collagen parameters to identify progression versus regression and / or prognosis are largely not readily available due to the difficulty of treatment in these diseases
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[0048] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
[0049] The terms "first" and "second" in the specification and claims of the present invention and the above drawings are used to distinguish different objects, rather than to describe a specific order. Furthermore, the terms "comprising" and "having", and any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, product or apparatus comprising a series of steps or units is not defined by listed steps or u...
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The invention discloses a hepatitis C fibrosis characteristic information extraction method and device, and the method comprises the steps: carrying out the imaging of a non-dyed slice of a target sample through SHG and TPE, obtaining a target image, obtaining an SHG parameter in the target image, and carrying out the quantification of the SHG parameter, and obtaining the morphological characteristics of collagen; predicting the histological response of a patient according to specific clinical characteristics and morphological characteristics of collagen, parameters meeting preset conditions with Ishak staging changes before and after treatment are selected, and generating a two-dimensional thermogram is. The Ishak staging change after the continuous virological reaction is predicted by utilizing the two-dimensional thermogram, and the prediction performance of the ISHAK fibrosis staging change is obtained. Therefore, fibrosis reversion of virus infection related fibrosis before treatment is predicted by using an optical technology, the current clinical requirements can be met, and a data basis is provided for subsequent clinical research.
Description
technical field [0001] The invention relates to the technical field of medical information processing, in particular to a method and device for extracting characteristic information of hepatitis C liver fibrosis based on second harmonic wave and two-photon excited fluorescence. Background technique [0002] Quantitative assessment of collagen in unstained tissue samples by second harmonic (SHG) and two-photon excited fluorescence (TPE) microscopy. In chronic fibrous disease, scar progression and regression often go hand in hand, and although the ongoing chronic injury is taken into account, the overall balance favors progression. Collagen parameters to identify progression versus regression and / or prognosis are largely unavailable due to the difficulty of treatment in these diseases. [0003] However, HCV eradication was successful in almost all patients, allowing the study of HCV progression and reversal characteristics. Furthermore, since such complete viral eradication ...
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Login to View More IPC IPC(8): G06T7/00G16H30/00G16H50/20G16H70/20
CPCG06T7/0012G16H30/00G16H50/20G16H70/20G06T2207/10056
Inventor 饶慧瑛刘峰魏来任亚运滕霄戴其尚
Owner PEOPLES HOSPITAL PEKING UNIV