Signal acquisition device for fluorescence imaging of laser scanning living body
A technology for in vivo fluorescence and imaging signals, which is applied in the fields of analysis, medical science, and diagnosis using fluorescence emission.
Pending Publication Date: 2020-01-03
邱海林
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[0005] In view of this, the present invention aims to propose a laser scanning in vivo fluorescence imaging signal acquisition device to solve the technical problem in the prior art that the signal acquisition efficiency is affected by astigmatism
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[0031] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.
[0032] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", " The orientations or positional relationships indicated by "vertical", "horizontal", "top", "bottom", "inner" and "outer" are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and Simplified descriptions, rather than indicating or implying that the device or element referred to must have a particular orientation, be constructed and operate in a particular orientation, and thus should not be construed as limiting the invention. In addition, the terms "first", "second", etc. are used for descriptive purposes only, and should not be understood ...
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Abstract
The invention provides a signal acquisition device for fluorescence imaging of laser scanning living body. The device comprises: a pulse laser device, an infrared fluorescence detector, a sample holding stage, and a scanning unit. The scanning unit comprises a galvanometer module and an objective lens, the galvanometer module is used to adjust the deflection according to a preset scan setting model, and the objective lens is connected to the galvanometer module and is used for imaging the laser after deflection according to the set resolution; the laser emission frequency of the pulse laser device and the deflection action of the galvanometer module are synchronized with the timing sequence acquisition of the infrared detector; and the sample holding stage is positioned in a spherical cavity, the inlet of the spherical cavity is provided with a signal output port of the spherical cavity, and the signal output port comprises no less than two optical fibers that are uniformly embedded inthe spherical cavity. The efficiency of fluorescence acquisition in fluorescence imaging tests of astigmatic materials including living body can be improved by the device.
Description
technical field [0001] The invention belongs to the field of microscopic imaging, and in particular relates to a laser scanning living body fluorescence imaging signal acquisition device Background technique [0002] Optical functional imaging is one of the fastest growing functional imaging methods. Photons, especially photons in the visible and infrared bands, have low energy and have little killing effect on living organisms, so they are suitable for dynamic monitoring of living organisms; spectral measurement has good molecular contrast and multi-parameter properties, and can contain rich molecular structures and microspaces Environmental information can reflect various metabolic processes and lesions; as a supplement to spectral measurement, fluorescence lifetime imaging can obtain functional information of samples, such as pH value, ion concentration (Ca2+, Na+, etc.), oxygen Quantitative measurement of physiological parameters such as pressure, and has been widely us...
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IPC IPC(8): A61B5/00
CPCA61B5/0071A61B2503/40A61B2503/42
Inventor 邱海林
Owner 邱海林