Encapsulated nutritional and pharmaceutical compositions
A technology of composition and lipid composition, which can be used in drug delivery, food science, pharmaceutical formulation, etc., and can solve problems such as poor emulsion stability and insufficient microcapsule efficiency
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[0047] The at least one hydrocolloid can be introduced into the emulsion or composition at any stage of its preparation to form a homogeneous aqueous dispersion or slurry. In the case of encapsulated compositions, the at least one hydrocolloid may be introduced before the encapsulating agent (for example in the aqueous phase), simultaneously with the encapsulating agent or after the encapsulating agent. A person skilled in the art will be able to optimize the amount of at least one hydrocolloid to be introduced without undue burden or undue experimentation. The amount of at least one hydrocolloid should be sufficient to produce a composition of the present application having the desired viscosity. In the case of oil-in-water emulsions, the viscosity should be sufficient for the emulsion to maintain the morphology of oil-in-water droplets. If the hydrocolloid level is too low, an unprotected encapsulation matrix may result, while if the hydrocolloid level is too high, the visc...
Embodiment 1
[0079] Example 1 Encapsulation of phospholipid-containing oils in the presence of hydrocolloids
[0080]Phospholipid-enriched krill oil (phospholipid content greater than 56%) encapsulated to form an oil-in-water emulsion, and then spray-dried. The stability of the emulsion and the surface free fat content of the spray-dried powder were investigated to evaluate the effect of the encapsulation system. process such as figure 1 shown.
[0081] refer to figure 1 , in the MRP system, the MRP aqueous solution was heated to 50-80°C, and mixed with krill oil at 6,000-12,000 rpm for 5 minutes, and then homogenized once under the pressure of 350 / 100 bar to prepare phospholipid-rich oil-in-water emulsion. The emulsion was further spray dried at an inlet temperature of 180°C and an outlet temperature of 80°C to produce the final powder product. In the absence of hydrocolloids, in the octenyl succinic anhydride modified starch matrix, octenyl succinic anhydride modified starch and su...
Embodiment 2
[0096] Example 2 - Shelf life of phospholipid-containing oils in the presence of hydrocolloids
[0097] A spray-dried powder comprising xanthan gum at a content of 0.3% w / w relative to water, prepared as described in Example 1 (see Table 1), was treated in a modified atmosphere (N 2 ) in the presence of 40°C in sealed bags for 24 weeks. After extraction of the stable oil from the powder, a series of oxidation parameters including peroxide value (PoV), p-anisidine value (p-AV) and DHA and EPA content. Peroxide value (PoV) and p-anisidine value (p-AV) are recognized indicators of primary and secondary oxidation product production.
[0098] To analyze the oxidative stability of the stabilized oil phase in the encapsulant, the entrapped oil was extracted and its peroxide value (PoV) and p-anisidine value (p-AV) were determined. In general, PoV is a measure of primary oxidation in lipids, which reflects oxidation and indicates possible future secondary oxidation. However, sever...
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