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Application of Saikosaponin a in Preparation of Drugs for Preventing and Treating Psoriasis

A technology of saikosaponin and psoriasis, which is applied in the field of biomedicine, can solve problems such as unclear mechanism and effect, and achieve the effects of inhibiting inflammation, inhibiting excessive proliferation, and inhibiting psoriasis

Pending Publication Date: 2020-01-31
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The mechanism and effect of saikosaponin a on psoriasis are not yet clear

Method used

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  • Application of Saikosaponin a in Preparation of Drugs for Preventing and Treating Psoriasis
  • Application of Saikosaponin a in Preparation of Drugs for Preventing and Treating Psoriasis
  • Application of Saikosaponin a in Preparation of Drugs for Preventing and Treating Psoriasis

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Experimental program
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Effect test

Embodiment 1

[0037] 1) Establishment of animal models in control group and experimental group and PASI score

[0038] A total of 42 BALB / c mice of 6 to 8 weeks were purchased from the Animal Experiment Center of Xi'an Jiaotong University School of Medicine, and were divided into control group, model group, treatment group and 3 administration groups, with 7 mice in each group, and each mouse weighed 22 ±2g. After anesthesia with 2% chloral hydrate, the back hair was shaved about 2×3 cm in size, and 62.5 mg of imiquimod cream was applied externally, once a day. The control group and the model group were intragastrically administered 0.9% normal saline 200μl, the treatment group was intragastrically administered an equal volume of methotrexate (MTX) 0.5mg / kg / d, and the administration group was intragastrically administered different doses (37.5mg / kg / d, 75mg / kg / day, etc.) kg / d and 150mg / kg / d) of saikosaponin a 200μl, once a day, photographed every day and scored by PASI for a total of 7 days...

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Abstract

The invention relates to an application of Saikosaponin a in preparing a medicine for preventing and treating psoriasis, belonging to the technical field of biomedicine. The medicine is obtained by taking saikosaponin a as an active component and dissolving saikosaponin a with normal saline as a solvent. A suitable dose of that medicine provided by the invention can be used for treating imiquimodpsoriasis model mice by gavage, which can inhibit inflammatory reaction of skin lesions of mice, improve the thickness of scales and skin lesions, and inhibit excessive proliferation of human epidermal keratinocyte HEKa cell line; Saikosaponin a slows down the progression of psoriasis and promotes the recovery of skin lesions to normal by inducing the reduction of cell mitochondrial transmembranepotential Delta psi and the production of oxygen free radical ROS. Compared with other drugs for treating psoriasis, the mechanism of action is clearer and the security is better.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of saikosaponin a in the preparation of medicines for preventing and treating psoriasis. Background technique [0002] Psoriasis is a common immune-mediated chronic relapsing inflammatory skin disease characterized by epidermal hyperplasia, immune cell infiltration, increased cutaneous angiogenesis, and local upregulation of various inflammatory mediators. The typical skin lesions of psoriasis are scaly erythema or plaque, and its recurrent attacks and long-term course have serious impact on the patient's body, mind, and spirit. The histopathological manifestations of psoriasis are mainly hyperkeratosis and parakeratosis, and neutrophil accumulations are often seen in the parakeratosis area, which is called Munro microabscess. The epidermis protrudes, the dermal papilla extends into a club shape, and the spinous layer above it becomes thinner. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P17/06
CPCA61K31/7048A61P17/06
Inventor 郑焱刘萌邵永平
Owner XI AN JIAOTONG UNIV
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