Application of Saikosaponin a in Preparation of Drugs for Preventing and Treating Psoriasis

A technology of saikosaponin and psoriasis, which is applied in the field of biomedicine, can solve problems such as unclear mechanism and effect, and achieve the effects of inhibiting inflammation, inhibiting excessive proliferation, and inhibiting psoriasis
CN110731965APending Publication Date: 2020-01-31XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2020-01-31

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Abstract

The invention relates to an application of Saikosaponin a in preparing a medicine for preventing and treating psoriasis, belonging to the technical field of biomedicine. The medicine is obtained by taking saikosaponin a as an active component and dissolving saikosaponin a with normal saline as a solvent. A suitable dose of that medicine provided by the invention can be used for treating imiquimodpsoriasis model mice by gavage, which can inhibit inflammatory reaction of skin lesions of mice, improve the thickness of scales and skin lesions, and inhibit excessive proliferation of human epidermal keratinocyte HEKa cell line; Saikosaponin a slows down the progression of psoriasis and promotes the recovery of skin lesions to normal by inducing the reduction of cell mitochondrial transmembranepotential Delta psi and the production of oxygen free radical ROS. Compared with other drugs for treating psoriasis, the mechanism of action is clearer and the security is better.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of saikosaponin a in the preparation of medicines for preventing and treating psoriasis. Background technique

[0002] Psoriasis is a common immune-mediated chronic relapsing inflammatory skin disease characterized by epidermal hyperplasia, immune cell infiltration, increased cutaneous angiogenesis, and local upregulation of various inflammatory mediators. The typical skin lesions of psoriasis are scaly erythema or plaque, and its recurrent attacks and long-term course have serious impact on the patient's body, mind, and spirit. The histopathological manifestations of psoriasis are mainly hyperkeratosis and parakeratosis, and neutrophil accumulations are often seen in the parakeratosis area, which is called Munro microabscess. The epidermis protrudes, the dermal papilla extends into a club shape, and the spinous layer above it becomes thinner. Th...

Claims

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