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Traditional Chinese medicine composition having effect of alleviating pain and application of traditional Chinese medicine composition

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve the problems of tolerance, addiction, adverse reactions, restriction of wide application and the like

Active Publication Date: 2020-02-07
DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used analgesics are divided into opioids (morphine, cocaine, etc.) and non-steroidal anti-inflammatory drugs (aspirin, etc.). Responses, especially the resulting tolerance and addiction, severely restrict its widespread clinical application

Method used

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  • Traditional Chinese medicine composition having effect of alleviating pain and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition having effect of alleviating pain and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition having effect of alleviating pain and application of traditional Chinese medicine composition

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Effect test

preparation example Construction

[0033] The preparation method of Chinese medicine composition described in the present invention, comprises the following steps:

[0034] 1) After mixing the raw materials, soak them in water to obtain a pre-extraction feed liquid;

[0035] 2) heating the pre-extraction feed liquid to 95-100°C for extraction, filtering after extraction, collecting and concentrating the filtrate to obtain a concentrated filtrate;

[0036] 3) The concentrated filtrate was freeze-dried for 24-36 hours to obtain the powder of the Chinese medicine combination extract, which was vacuum-packed.

[0037] The heating and extraction times are 3 to 4 times, and the time of each extraction is 60 to 90 minutes.

[0038] Specifically, in the present invention, the raw materials of the traditional Chinese medicine composition are mixed in proportion and soaked in water. In the present invention, the volume ratio of the raw material volume to the water for each soaking is 1:3-5, more preferably 1:3; the soa...

Embodiment 1

[0048] 20g Radix Paeoniae Alba, 20g Radix Paeoniae Alba, 15g Yuanhu, 10g Bupleurum, 10g Curcuma, 10g Radix Paeoniae Rubra, 10g Guizhi, 8g Aconite, 10g Cinnamon, 8g Frankincense, 8g Myrrh, 10g Cyperus Cyperi, 10g Chuanxiong, Licorice 5g was mixed with raw materials, soaked in 1L of water at room temperature for 1.5h, heated the mixed material solution soaked with the raw materials at 100°C for 60min, and filtered to obtain filtrate 1 and filter residue 1. Mix 1 L of water with filter residue 1, heat at 100°C for 60 min, and filter to obtain filtrate 2 and filter residue 2. Mix 1L of water with filter residue 2, heat at 100°C for 60 min, and filter to obtain filtrate 3 and filter residue 3. The filter residue 3 was discarded, the filtrate 1, the filtrate 2 and the filtrate 3 were combined, heated and concentrated; the concentrated filtrate was freeze-dried for 30 hours to obtain the Chinese medicine combination extract powder, which was vacuum-packed.

Embodiment 2

[0050] 1. Experimental purpose: Validation of the efficacy of analgesic traditional Chinese medicine extracts

[0051] (1) Experimental settings

[0052] Animals: SPF grade Kunming mice, weighing 20±2g, half male and half male, record the qualified number and purchase source. Divided into blank control group, positive control group, low dose of analgesic formula extract group, middle dose of analgesic formula extract group, high dose of analgesic formula extract group, a total of 5 groups, 10 rats in each group.

[0053] Experiment period: 6 days.

[0054] (2) Experimental process

[0055] Blank control group: 0.4ml of distilled water was given by intragastric administration, once a day.

[0056] Positive control group: intragastric administration of 0.4ml aspirin, 0.2g / kg, once a day.

[0057] Low-dose group of extracts of Zhentongfang: 0.4ml aqueous solution of extract samples, 50mg / kg, once a day by intragastric administration.

[0058] The medium-dose group of the ext...

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Abstract

The invention provides a traditional Chinese medicine composition having effect of alleviating pain, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by weight of 10-30 parts of siegesbeckia herbs, 10-30 parts of white peony roots, 10-25 parts of radix bupleuri, 10-30 parts of radix curcumae, 10-30 parts of roots of herbaceous peonies, 10-30 parts of rhizoma corydalis, 10-25 parts of cassia twigs, 5-20 parts of prepared aconite roots, 10-30 parts of cinnamon, 5-20 parts of frankincense, 5-20 parts of myrrh, 10-30 parts of nutgrass galingale rhizomes, 10-25 parts of ligusticum wallichii and 5-20 parts of licorice roots. According to the record of the embodiment of theinvention, the traditional Chinese medicine composition has notable effect of alleviating pain.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to an application in preparing and treating diseases such as acute or chronic pain. Background technique [0002] Pain is a common feeling of worry and fear that affects a patient's mobility and overall quality of life. Pain is defined by the International Association for the Study of Pain as: an unpleasant sensory and emotional experience associated with underlying or existing tissue damage. Pain has brought great suffering to patients, seriously affected their quality of life, and caused heavy economic and psychological burdens on patients. Therefore, the International Association for the Study of Pain has designated October 11th as "World Pain Relief Day" every year. We call on the whole world to find effective measures to treat pain. It can be seen that finding safe and effective analgesics to solve patients' persistent pain has ext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/00A61P29/00
CPCA61K36/233A61K36/236A61K36/28A61K36/324A61K36/328A61K36/484A61K36/54A61K36/65A61K36/66A61K36/71A61K36/714A61K36/8905A61K36/9066A61K2236/331A61K2236/39A61K2236/51A61P25/00A61P29/00A61K2300/00
Inventor 田贵华林生商洪才夏欢李心怡
Owner DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE