A non-invasive quantitative detection method for organ fat based on the principle of magnetic resonance

Abstract

The invention discloses a method for non-invasive quantitative detection of organ fat based on the principle of magnetic resonance, which is characterized in that: the invention uses an external computer, a radio frequency RF subsystem and a portable magnet module to construct a low-field nuclear magnetic resonance non-invasive quantitative detection system for organ fat , no damage to organs, tissues and cells, no wound, to achieve accurate, non-invasive quantitative detection of organ fat. A specific pulse sequence is used to excite the nuclear spins in the target sample to generate low-field nuclear magnetic resonance, which realizes "one-key" detection and is used for fast and economical screening of NAFLD and other related diseases. It has a wide range of applications, is light and easy to carry, High cost performance, accurate quantification, convenient operation and not restricted by the qualifications of operators, can obtain ideal signals in the subcutaneous 5-10cm area, high measurement robustness, and noise and interference have little influence on measurement. Especially dictionary matching based methods are typical of the low signal-to-noise ratio of the applications covered by this patent. The deficiencies of the prior art are overcome.

Description

technical field [0001] The invention relates to the technical field of nuclear magnetic resonance medical detection, in particular to a method for non-invasive quantitative detection of organ fat based on the principle of magnetic resonance. Background technique [0002] About 25% of the global population is suspected to have non-alcoholic fatty liver disease (NAFLD), and many remain undiagnosed due to the lack of feasible, realistic and accurate methods for early detection and monitoring. The current gold standard for diagnosing NAFLD is liver biopsy, which is expensive and invasive, and is not suitable for early detection. Conventional ultrasound imaging is widely used, but it can only provide qualitative information and is highly operator-dependent. In addition, in NAFLD patients often have symptoms of obesity and subcutaneous fat excess, ultrasonography is difficult to obtain reliable results. Conventional MRI is an emerging NAFLD status monitoring technique, which has...

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Problems solved by technology

[0004] The purpose of the present invention is to provide a non-invasive quantitative detection method for organ fat based on the principle of magnetic resonance, which reasonably solves the problem of high cost of detection and detection of organ fat in the prior art, large damage, inapplicability of early screening detection and conventional ultrasonic imaging, and Strong operator dependence, poor reliability of results, and inability to achieve quantitative detection

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