Disinfectant citric acid malic acid powder for livestock and preparation method thereof
A technology of malic acid powder and citric acid, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, powder transportation, etc., can solve the problem of unseen mature products, unstable quality and product caking and other issues to achieve the effects of high security, good liquidity and improved stability
Inactive Publication Date: 2020-02-14
HENAN SOAR VETERINARY PHARMA +1
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Problems solved by technology
[0004] Since both citric acid and DL-malic acid have hygroscopicity, it is easy to cause agglomeration, discoloration and unstable quality of the products circulating in the market. At present, there is no mature product in this veterinary drug preparation
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[0019] The present invention will be further described below in conjunction with specific embodiments. It should be understood that the following examples are only used to illustrate the present invention but not to limit the scope of the present invention.
[0020] Comparative example 1~2 and embodiment 1~8
[0021] A kind of veterinary disinfectant citrate malic acid powder, the composition of raw materials is shown in Table 1.
[0022]
[0023] Preparation method, temperature and humidity control in the production workshop: the temperature is 26 ° C, the relative humidity is 27%, and the preparation steps are as follows:
[0024] (1) According to Table 1, weigh citric acid, DL-malic acid, sodium lauryl sulfate, mannitol, sodium hexametaphosphate, and anhydrous glucose according to Table 1, and pulverize all raw materials using a water-cooled pulverizer And pass through 80 mesh sieve;
[0025] (2) Add sodium hexametaphosphate and the same amount of anhydrous glucose in...
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The invention belongs to the technical field of veterinary drug preparations, and discloses a disinfectant citric acid malic acid powder for livestock and a preparation method thereof. The powder is prepared from the following raw materials in percentage by weight: 36 to 44 percent of citric acid, 9 to 11 percent of DL-malic acid, 4 to 6 percent of lauryl sodium sulfate, 15 to 25 percent of mannitol, 0.3 to 0.5 percent of sodium hexametaphosphate and the balance of anhydrous dextrose. According to the preparation method, the temperature and humidity control conditions of a production workshopare as follows: the temperature is room temperature, and the relative humidity is below 30%. The method comprises the following steps: (1) respectively crushing and sieving all raw materials; (2) premixing the sodium hexametaphosphate and the anhydrous dextrose for multiple times by adopting an equivalent progressive increase dilution method, then adding all the remaining raw materials, and then carrying out total mixing, wherein in the whole mixing process of the step, drying and mixing are performed at the same time; and (3) sub-packaging the semi-finished product mixed in the step (2), andperforming sealing to obtain the disinfectant citric acid malic acid powder for livestock. The prepared product has the advantages of low water content, low deliquescence tendency and favorable flowability, completely conforms to the product quality standard detection requirements, and has no national drug administration risk.
Description
technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a veterinary disinfectant citrate malic acid powder and a preparation method. Background technique [0002] In the current intensive livestock and poultry breeding process, the livestock and poultry breeding environment is prone to pathogenic microorganism pollution. In the livestock and poultry house, air, breeding equipment, drinking water, feed, feces, etc. will carry a large number of pathogenic microorganisms, which can easily cause infection The outbreak of the disease caused the occurrence of the epidemic and caused huge economic losses to livestock and poultry breeding. Therefore, it is extremely important to do a good job of disinfection and purification in the livestock and poultry breeding environment to prevent the occurrence and spread of the epidemic. [0003] Citric acid and DL-malic acid can reduce the pH value of pathogenic micro...
Claims
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IPC IPC(8): A61K9/14A61K31/194A61K47/20A61K47/26A61K47/02A61P31/04
CPCA61K9/143A61K9/145A61K31/194A61P31/04A61K2300/00
Inventor 刘联盟李灵娟吕凤霞刘升吕明霞高贵超
Owner HENAN SOAR VETERINARY PHARMA