Organic solvent liquid compression rate online test method and system based on micro-upgraded volume

Abstract

The invention relates to an organic solvent liquid compression rate online test method and system based on micro-upgraded volume. An organic solvent is compressed online by controlling reciprocating motion of a liquid phase pump and using micro-upgraded volume of a liquid end of a liquid phase pump, a pressure value of a liquid path system is read in real time, and a pressure increase is correlated with a compression value, so that micro-upgraded volume organic solvent liquid compression rate is tested online. When a high-precision ultrahigh pressure liquid phase pump transports an organic solvent, ultrahigh pressure compression of a liquid solvent may affect flow accuracy, the method solves the above problem; when an ultrahigh pressure high-precision organic solvent is transported, onlinetest of the organic solvent compression rate provides necessary data support for flow accuracy control, pulsatility and high pressure sealing performance of a flow path system, and compensates compression in real time, so as to guarantee that the consistency indicator of transport flow accuracy and the pulsatility indicator of constant flow can keep stable.

Description

technical field [0001] The invention relates to on-line measurement of the compressibility of an organic solvent under a high-pressure state, which is applied to ultra-high pressure liquid phase analysis and belongs to the field of liquid phase technology. Background technique [0002] The high-precision ultra-high pressure liquid phase pump (UHPLC) is developed on the basis of the high-performance liquid chromatography pump (HPLC). The stationary phase and high-efficiency chromatographic column used in it can increase the pressure at the output end of the pump to 150MPa, and the sample analysis The time is shortened from 10min-30min by HPLC to 40s-2min, which greatly shortens the sample analysis time, and its high sensitivity can effectively reduce cross-contamination. The fields of medicine, biochemistry, and food analysis have a wide range of application requirements for UHPLC. [0003] The compressibility of a fluid is the condition of a fluid particle under a certain p...

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Problems solved by technology

[0004] The compressibility value of the fluid is determined by the ratio of the volume difference under two different pressure values. At present, through the common movement of the primary and secondary reciprocating piston pumps in foreign countries, the change of the fluid volume is realized, thereby determining the compression ratio of the fluid. This method achieves The process is complicated, requiring the piston movements of the primary and secondary reciprocating pumps to cooperate with each other in time, and requires the movement process of the primary and secondary reciprocating pumps to be crossed.

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