Application of SPD_0310 protein as target spot in preparation of medicine for preventing and treating streptococcus pneumoniae infection

A Streptococcus pneumoniae and protein inhibitor technology, applied in the field of protein science, can solve the problems of low detection sensitivity, low expression, and inability to detect, and achieves the effect of good broad-spectrum, good broad-spectrum, and high conservation
CN110812484AActive Publication Date: 2020-02-21JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2020-02-21

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Abstract

The invention discloses an application of SPD_0310 protein as a target spot in preparation of a medicine for preventing and treating streptococcus pneumoniae infection. The invention finds that the expression quantity of the SPD_0310 in three mutant strains with three main iron transport genes of streptococcus pneumoniae knocked out at the same time is increased, and the SPD_0310 can normally grow, which indicates that the SPD_0310 protein may participate in the interaction of various iron transport proteins. The invention also finds that the infectivity of the SPD_0310 gene-knockout strain tomice is reduced, and on the basis, the SPD_0310 can be used for preparing an antibody of the protein, so that antibody drugs can be researched and developed. Besides, the invention also finds that the active center of the protein can be combined with heme, and proves that porphyrin drugs can be used as a substrate to compete with the heme, which indicates that the porphyrin drugs can be used as an inhibitor of the SPD_0310 to inhibit the toxicity of the streptococcus pneumoniae, so that the porphyrin drugs have wide application prospects in the field of antibacterial drugs.
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Description

technical field

[0001] The invention belongs to the field of protein science and technology, and particularly relates to the application of SPD_0310 protein as a target in the preparation of drugs for preventing and treating Streptococcus pneumoniae infection. Background technique

[0002] Streptococcus pneumoniae is a Gram-positive pathogenic bacterium, and it is also the main pathogenic microorganism that causes human infection and even death worldwide, especially for the elderly and children with weak resistance. According to the World Health Organization (WHO) According to incomplete statistics, the bacteria cause about 1.6 million deaths every year. After this bacterium infects the human body, it mainly causes serious diseases such as pneumonia, otitis media (AOM), sepsis, acute renal failure and meningitis. At present, there is no specific drug in the world that can completely inhibit the toxicity of this bacterium. Therefore, people's strategies for this bacterium ar...

Claims

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